DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nolo and adamts10

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_001116746.1	Gene:	adamts10 / 564734	ZFINID:	ZDB-GENE-081104-414	Length:	1108	Species:	Danio rerio

Alignment Length:	839	Identity:	191/839 - (22%)
Similarity:	267/839 - (31%)	Gaps:	358/839 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 GGPGQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPCP-EQQDFR 130
            |..|.|..||.|..|||||.||:...:|.|.||..      |.||..|:|.||:..|| ..||||
Zfish   550 GVDGGWGHWSPWEECSRTCGGGVSSSIRHCDSPRPTVGGKYCLGERKRFRSCNIDECPVGSQDFR 614

  Fly   131 SSQCSAYNDVPYDGTLYKWTPHY-DYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSV 194
            ..|||.::.||:.|..|.|.|:. ..|:.|:|.|.                  ||....|.|:
Zfish   615 EIQCSDFDSVPFRGKFYTWKPYRGGGVKSCSLNCL------------------AEGYNFYTER-- 659

  Fly   195 IVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCS--QPLFNWE 257
                :..|.|||.||..|||:|:.|:|:.||||..:||..:.|.|.||||||:||.  :.:||..
Zfish   660 ----APAVVDGTPCRDDSLDVCVNGECKHVGCDRILGSDVREDRCRVCGGDGSSCQVIEGVFNDS 720

  Fly   258 MAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASV----EQCN----------- 307
            ::.         .||:                    .|...|:.||    ::.|
Zfish   721 LSE---------GGYE--------------------EVVRIPKGSVFIHIQELNISLNYLVLKSK 756

  Fly   308 ----------THSCPPRWIADDWSTCSRLCGHGYRER---------------------MVVCAEE 341
                      |...|.|:         .:.|..:..|                     ||:..||
Zfish   757 GDQYFINGKLTIDTPRRF---------DIAGGTFHYRRPANEPETLEALGPTNMTLIVMVLVREE 812

  Fly   342 SNGIKTRVADIMCRTPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAK 406
            :.||..|....:.|.|.....          |....|:.||..|..|:|::.|.||
Zfish   813 NPGILYRFNPPVSRDPLSSYS----------WHYTSWSRCSALCAGGVQVQQVVCK--------- 858

  Fly   407 CDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDV 471

Zfish   859 ----------------------------------------------------------------- 858

  Fly   472 DDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPS 536
                           ..||..::|.|
Zfish   859 ---------------KQADLSVVYNH--------------------------------------- 869

  Fly   537 LDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGK-KPHDEVERCVEDPC 600
                                                         .|:.| ||.|:...|.::||
Zfish   870 ---------------------------------------------FCDKKNKPKDKKRPCNQEPC 889

  Fly   601 MLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVRE---DNGRVVS 662
                                 .|    .|....::.||.||.|||....:.|.|:   ...:|:.
Zfish   890 ---------------------PP----TWWTGDWSECSRSCNGGVRTREVLCKRKMSVTEEKVLD 929

  Fly   663 PFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPN 727
            ...|: .|:|.. ...||:..|||.|:..|::.|:..||.|.:.|.:.|     |.|||...:|.
Zfish   930 DTACT-TTRPSV-TEPCNNHTCPPEWHALDWSECTPGCGPGYRYRVILC-----RSGDNGETLPE 987

  Fly   728 SMCP-QPPPADRQYCNVLDC-PVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMC 790
            |.|| |..|..|..||:..| |.:|..|.|.:||..||.|.:.|.|:|.....|      |.:.|
Zfish   988 SECPKQSRPTTRVRCNIQRCPPPQWVAGPWGECSARCGMGQEIRFVQCLTHTGQ------PSNEC 1046

  Fly   791 P-SAKPADKKPCNVKPC----PPEDPKPVIQINNSTHIQHDPKKTKITLKVGGAGLVFF 844
            | |.:||..:.|..| |    |.::|:....:|.   :.:.|    :.|:....|..:|
Zfish  1047 PESHRPAFMQQCKSK-CDHSGPTDNPEECKDVNT---VAYCP----LVLRFKFCGRAYF 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	22/51 (43%)
		TSP1	546..600	CDD:214559	6/54 (11%)
		TSP1	750..807	CDD:214559	21/61 (34%)
		IGc2	845..902	CDD:197706	191/839 (23%)
		PLAC	1355..1384	CDD:285849
adamts10	NP_001116746.1	Pep_M12B_propep	71..189	CDD:279848
		Reprolysin	244..462	CDD:279729
		ZnMc_ADAMTS_like	244..459	CDD:239801
		TSP1	555..607	CDD:214559	22/51 (43%)
		ADAM_spacer1	711..823	CDD:283607	21/149 (14%)
		TSP1	893..950	CDD:214559	16/58 (28%)
		PLAC	1074..1106	CDD:285849	5/31 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11660
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810