DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and ADAMTSL4

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_011507946.1	Gene:	ADAMTSL4 / 54507	HGNCID:	19706	Length:	1130	Species:	Homo sapiens

Alignment Length:	978	Identity:	204/978 - (20%)
Similarity:	293/978 - (29%)	Gaps:	456/978 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RSKVQSAGGGGGAGG------------GPGQW-----------SSWSDWSTCSRTCDGGIMHQMR 100
            |.:.|...|..|.||            .||.|           |.||.:
Human   340 RGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLF---------------- 388

  Fly   101 RCGSPGS----CRGESTRYRICNMQPC-PEQQDFRSSQCSAYNDVPYDGTLYKWTPHYDYVEPCA 160
               :|.|    |.|||.:.|.|:..|| |||.|.|:.||:|:|...:.|.||:|.|   :.|...
Human   389 ---APSSPIPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEP---FTEAPL 447

  Fly   161 LTCRGHPAHLVEDISRETGDGNAEEAEHYDEQS-------VIVQLSARVQDGTRCRSGSLDMCIQ 218
            |..| |...|:....  :||....:.....|.:       ..|:.:.:|||||.|:.|:.|:|:.
Human   448 LPLR-HAFFLLPGAG--SGDSTGVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVA 509

  Fly   219 GKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC---------------------------------- 249
            |:|...|||..:||.::.|||||||||.::|
Human   510 GRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQL 574

  Fly   250 ----------------------------------------------------------------- 249

Human   575 RPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVY 639

  Fly   250 ----------------------------------------------------------------- 249

Human   640 MIFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRI 704

  Fly   250 -------------SQPLFNWEMAPMSQCSVTCGSGYKMSRPI--CRNRLTNADVDDTLCSVTNRP 299
                         ..|...|:....|.||.:||.|  :.|||  |.:|.:..::|:..|:...||
Human   705 PQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKG--VWRPIFLCISRESGEELDERSCAAGARP 767

  Fly   300 EASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMC-RTPKPPTQE 363
            .||.|.|:...|||.|.|.:|::|||.||.|.:.|.:.|.:|..|..:.|....| ..|:|...:
Human   768 PASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQ 832

  Fly   364 TCIIEECPHWEV-EDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGG 427
            :|.:..|.|||| ..|:.|||.||:|.:.|.|.|...:|      |.:    |.|:|::|
Human   833 SCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG------DEV----SEQECASG----- 882

  Fly   428 SLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQP 492

Human   883 ----------------------------------------------------------------- 882

  Fly   493 LLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEW-SPCSVTCGE 556
                           |.:|.:.              |....||.....:..|  | |.||..||.
Human   883 ---------------PPQPPSR--------------EACDMGPCTTAWFHSD--WSSKCSAECGT 916

  Fly   557 GIRRRTYNC-----KIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSI 616
            ||:||:..|     .:........|....|...|.:|.| :..|...||
Human   917 GIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPD-MRACSLGPC---------------- 964

  Fly   617 KVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVRE--DNGRVVSPFLCSPETKPEARVRTC 679
                   .:|:.|....:..||:.|..|.:...|.||.:  ....|.||..||...:|.| ::.|
Human   965 -------ERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPA-LQPC 1021

  Fly   680 NDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNVL 744
            ..:.|..||..:.::|||:||..|.:||||||:        :|....::.||
Human  1022 QGQACQDRWFSTPWSPCSRSCQGGTQTREVQCL--------STNQTLSTRCP------------- 1065

  Fly   745 DCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCP-- 807
                                                          |..:|:.|:|||.:||.
Human  1066 ----------------------------------------------PQLRPSRKRPCNSQPCSQR 1084

  Fly   808 PED 810
            |:|
Human  1085 PDD 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	14/61 (23%)
		TSP1	546..600	CDD:214559	17/59 (29%)
		TSP1	750..807	CDD:214559	7/56 (13%)
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
ADAMTSL4	XP_011507946.1	TSP1	80..>110	CDD:214559
		ADAM_spacer1	541..655	CDD:283607	0/113 (0%)
		TSP1	783..839	CDD:214559	18/55 (33%)
		TSP1	842..897	CDD:214559	23/163 (14%)
		TSP1	1033..1082	CDD:214559	22/115 (19%)
		PLAC	1089..1118	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810