DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and adamts9

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_001361725.1	Gene:	adamts9 / 493280	XenbaseID:	XB-GENE-1013537	Length:	1923	Species:	Xenopus tropicalis

Alignment Length:	1740	Identity:	351/1740 - (20%)
Similarity:	516/1740 - (29%)	Gaps:	762/1740 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVNMN-WTSPKIWAAL---FVTTL-------CLLDTQAAWAKKL---------NASQAFD---- 41
            |:..:| :|:|.:|:..   :||..       ||||...:....|         |.::..:
Frog   446 MAPTLNFYTNPWMWSKCSRKYVTQFLDTGYGECLLDEPISRTYTLPQQLPGALYNVNKQCELIFG 510

  Fly    42 --------------DTWNTASDLENELEQQKRSKVQSAGGGGGAGGGPGQ--------------- 77
                          ..|..:||     .|.|..:.|......|....||:
Frog   511 PGSQVCPYMQMQCRRLWCISSD-----GQHKGCRTQHTPWADGTECEPGKHCRYGVCIPKERDVQ 570

  Fly    78 -----WSSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPCPE-QQDFR 130
                 |.|||.:..|||:|.|||...:|.|..|..      |.|...:::.||.:.|.: ::|||
Frog   571 IADGSWGSWSPFGACSRSCGGGIKTSIRECNRPEPKNGGKYCVGRRMKFKSCNTELCAKHKRDFR 635

  Fly   131 SSQCSAY-------NDVPYDGTLYKWTPHYDYV---EPCALTCR--GHPAHLVEDISRETGDGNA 183
            ..||:.:       |.:|.:   .:|.|.|..:   :.|.|.||  |..|:
Frog   636 EEQCADFDGKHFNINGLPPN---VRWVPKYSGILMKDRCKLFCRVAGSTAY-------------- 683

  Fly   184 EEAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNS 248
                        .||..||.|||.|...:.|:|:||.|::.|||..:.|..:.|.|||||||.:|
Frog   684 ------------YQLRDRVVDGTSCGPDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSS 736

  Fly   249 C-----------------------------------SQP-------------------------- 252
            |                                   .:|
Frog   737 CKTIAGTYNIVHYGYNSVVRIPAGATNLDVRQHSYSGKPEDDNYLALSNSHGEFLLNGDFVVSMF 801

  Fly   253 ------------------------------------------LFN-------------------- 255
                                                      |:|
Frog   802 KREIKVGNAVIEYSGSDNAIERINCTDRIEQEIVLQILSVGNLYNPDVRYTFNIPIEDKPQQFYW 866

  Fly   256 ---------------------------------------------------------WEMAPMSQ 263
                                                                     |.:|..|:
Frog   867 NPYGPWQPCNKMCQGERKQKPVCIRDSDQLVVSDQRCDRIPQPEPVTEPCNTECEVRWHVARKSE 931

  Fly   264 CSVTCGSGYKMSRPICRNRLTNAD-----VDDTLCSVTNRP---EASVEQCNTHSCPPRWIADDW 320
            |:|.||.||:.....|. :.|.||     ||:..||...:|   |.....|||..    |....|
Frog   932 CTVQCGLGYRTLDIHCA-KYTRADGKNEKVDERYCSHLQKPLTKEKCSGDCNTGG----WRYSPW 991

  Fly   321 STCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEVEDWTGCSVSC 385
            |.||:.||.|.|.|..:|.   |.:...:.|..|...:.||::.|....||.|:..||:.|.|:|
Frog   992 SECSKSCGTGTRRRRAICV---NALHDILDDSKCGQQEKPTEQRCSEFPCPQWKTGDWSDCLVTC 1053

  Fly   386 GQGIQMRGVECKSTDGSLSAK-CDPLTKPGSMQ----------------QCSTGIHCGGSLNKVG 433
            |:|.:.|...|:..|..|..: ||..|||.|::                ||:..  ||.......
Frog  1054 GKGHKHRQTWCQFGDDRLHDRFCDTETKPESVEACEQPECASWQVGPWGQCTAA--CGPGYQMRV 1116

  Fly   434 GTIIVGSSRSLNERSE-----RQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPL 493
            ...:||:.|::.:.||     |..|:.|.                     :.|...|:....|
Frog  1117 VKCVVGAYRAVVDDSECNAATRPTDTQDC---------------------EADACPGIPETKQ-- 1158

  Fly   494 LYAHRTQSRLNQEAPDEP---RTMHLMNGNSNNNFNRGEDE-----------SEGPSLDPT-YIK 543
            :...|||.|.....|...   :...:...:..::.....||           :|..|:.|. ..|
Frog  1159 IVHSRTQWRFGSWTPCSATCGKGTRMRYVSCRDDQGSVADEAACAQLPKPLATEACSVTPCGQWK 1223

  Fly   544 DNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHD--EVER-CVEDPCMLPSH 605
            ..|||.||||||:|...|...|..|.:     .||:.|.|:   |.|  .||: |...||...:|
Frog  1224 ALEWSSCSVTCGQGKATRQVICVDFAD-----QTVDGSECD---PDDVPAVEQECSMSPCYYLNH 1280

  Fly   606 GFD---DQFPRDSIKVGVSEPGKTYV--------------WREQGYTSCSASCLGGVEELIINCV 653
            .:.   ...|....::. |.|....:              ||...:.:||::|.||.:..::.|
Frog  1281 DYSKPIQTVPNTDHRIR-SNPTLAILNRNTGRPAGSGGSQWRTGPWGACSSTCAGGFQRRVVVC- 1343

  Fly   654 REDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRG 718
            :::||...|.  |..:||| ...|:|....| |:|.:.::..|||.||.|.:||:|.|...   .
Frog  1344 QDENGYPASN--CDEKTKP-IEQRSCESGSC-PQWAFGNWGECSKKCGGGTRTRQVVCQRS---N 1401

  Fly   719 GDNTMVVPNSMCPQPPPADRQYCNVLDCP--VRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEH 781
            ||....:...:..:||  ||:.||:..||  ..|..|.|:.||.:||.|.|.|.|.|   :.:|.
Frog  1402 GDIFNDLSCEILDKPP--DREQCNMHSCPRETGWNSGPWNVCSVSCGRGVKTRPVYC---VTKEG 1461

  Fly   782 KIERPESMCPSAKPADKKPCNVKPCPPEDPKPVIQINNSTHIQHDPKKTKITLKVGGAGLVFFGT 846
            ....||:....|||..:|.|.                                  ||
Frog  1462 VTVEPENCKHLAKPNIQKKCR----------------------------------GG-------- 1484

  Fly   847 QVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISI 911
                |||         ||                |.|......:|        |..|:
Frog  1485 ----KCP---------KW----------------KAGEWEKCSVT--------CGRGI------- 1505

  Fly   912 EVKAKPGQQIEELEQQETERLVREKSGTEALTSADMKSADGTGTSTAVGPNSHVNGSAQQHGSRR 976

Frog  1506 ----------------------------------------------------------------- 1505

  Fly   977 RQQQSERLQNGRERSRRPKSDGVQHADSSIMEDDLSQLVQSEDRIPQPASASSGGSRTRTLLAMP 1041
             ||::...|.|.::..| :|:..|||
Frog  1506 -QQRAVHCQVGAQKMSR-ESECPQHA--------------------------------------- 1529

  Fly  1042 YFQALLSNLQLLWPLQRFKDSRGQHLLQGEALKFGIDLSGKDFDQDESERVPAEQLPPEVLHSPS 1106
                                                             |.|:||.
Frog  1530 -------------------------------------------------RPPSEQY--------- 1536

  Fly  1107 DPEYHEPSKSGPEADVPHVPPHMPHARWETGAAASTTAVPSLPNDGFVYRWMLGEWSQCSQECGA 1171
                         ..|...|                           :|.|...||.:||:.|
Frog  1537 -------------CQVAECP---------------------------LYTWKAEEWQECSKTC-- 1559

  Fly  1172 AGSGLQRRTVSCQRAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQSCGNEACP-QWSKGDW 1235
             ..||:.|...|            .|.:...|..|.|..:  :.|...:.|..::|. .|..|:|
Frog  1560 -DEGLRYRKAIC------------LDEDKKEVPQSHCEEN--KKPPEVEKCNVQSCEFLWITGEW 1609

  Fly  1236 TPCQRSHCHGRNTAMQRREVTC--------RYPNGTEGSICDEYERPAMRQECYNERC--EGVWR 1290
            :.|..: |   .|..::|.|||        .|..|.:.|.....|:|...|.||...|  ...||
Frog  1610 SECSVT-C---GTGYKQRLVTCSEVYSAKDHYEYGYQSSANCPGEQPPTVQNCYQGECPISASWR 1670

  Fly  1291 VEPWSECNAPCGRKGIKYRILQCVWYGSRRPAGNVCKHQPRPAVMKVCKS-PACQAQLSSSPAQL 1354
            |..|.:|:..|| .|:..|.:||:  .:.....|:|....:|...::|.| ..|
Frog  1671 VGNWGKCSVTCG-SGVTQRSVQCL--TNEDLPSNMCSVDQKPEEKRICYSNHDC----------- 1721

  Fly  1355 CRDSSRYC---RNARAMGLCRLHR-------YKLKCCGSCEQQPNQHLIL 1394
              |..|.|   :..:.:|....|.       .|:.|.|...:.|.:::.|
Frog  1722 --DLPRNCLEVKRLKHVGADGEHYVMIQEKIIKIYCAGMQSESPKEYITL 1769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	18/51 (35%)
		TSP1	546..600	CDD:214559	22/56 (39%)
		TSP1	750..807	CDD:214559	20/56 (36%)
		IGc2	845..902	CDD:197706	9/56 (16%)
		PLAC	1355..1384	CDD:285849	8/38 (21%)
adamts9	NP_001361725.1	Pep_M12B_propep	44..192	CDD:366707
		ZnMc_ADAMTS_like	274..480	CDD:239801	8/33 (24%)
		ADAM_CR_2	495..563	CDD:375321	10/72 (14%)
		TSP1	576..627	CDD:214559	18/50 (36%)
		ADAM_spacer1	738..856	CDD:368694	3/117 (3%)
		TSP1	986..1039	CDD:214559	17/55 (31%)
		TSP1	1041..1093	CDD:214559	18/51 (35%)
		TSP1	1096..1151	CDD:214559	13/77 (17%)
		TSP1	1166..1219	CDD:214559	6/52 (12%)
		TSP1	1219..1275	CDD:214559	23/63 (37%)
		TSP1	1320..1372	CDD:214559	18/56 (32%)
		TSP1	1374..1428	CDD:214559	19/58 (33%)
		PTZ00441	<1467..>1531	CDD:240420	27/304 (9%)
		TSP1	1550..1601	CDD:214559	15/67 (22%)
		TSP1	1604..1664	CDD:214559	18/63 (29%)
		GON	1726..1922	CDD:370060	8/44 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11921
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000