DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nolo and AdamTS-A

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster

Alignment Length:	1098	Identity:	217/1098 - (19%)
Similarity:	319/1098 - (29%)	Gaps:	437/1098 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 GGGGGAGGGPGQWSSWSDWSTCSRTCDGGIMHQMRRCGSP-----GS-CRGESTRYRICNMQPCP 124
            |.|....||   |..|:.::.||.||.||:....|.|..|     |. |.|...:||.||...||
  Fly   745 GYGRQVNGG---WGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCP 806

  Fly   125 E-QQDFRSSQCSAYN----DVPYDGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAE 184
            . ..|.|..||.|.|    ::|......||.|.|: .:.|.|.||
  Fly   807 PGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE-KDACKLFCR-------------------- 850

  Fly   185 EAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC 249
                .|.:.....|.:.|.|||.|...|.|.|:.|.|:..|||.::.|..|:|.||||.|..::|
  Fly   851 ----MDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTC 911

  Fly   250 ------------------SQP-------------------------------------------- 252
                              ::|
  Fly   912 HEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGK 976

  Fly   253 ----------------------------------------------------------------- 252

  Fly   977 FLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYT 1041

  Fly   253 ------------LFNWEMAPMSQCSVTC-GSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVE 304
                        ::.|||...|.|...| |..:::  |.|.:......|....|..:..|:....
  Fly  1042 IDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRL--PACISTTQGVKVAPQFCDKSAMPKIDDR 1104

  Fly   305 QCNTHSCPPRWIADDWSTCSRLCGH-GYRERMVVCAEE-SNGIKTRVADI-MCRTPKPPTQETCI 366
            .||| .|.........|.||..||. |.||:...|.:. :|..::.:.|: .|:.    ..:...
  Fly  1105 ACNT-DCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKL----KFDVAY 1164

  Fly   367 IEECPH--WEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAK-CDPLTKPG--------SMQQCS 420
            .|||..  |.:.:|:.||.|||.|.|.|...|...:..:|.. |:|.|||.        :.:.|.
  Fly  1165 HEECREGCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCP 1229

  Fly   421 TGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEG 485
            |......:|  .....::|.....||..|:....|
  Fly  1230 TYTKSPNAL--AVSNWVIGEWGECNEWCEKTRSVS------------------------------ 1262

  Fly   486 LSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPC 550
               ...|  |.....||   :..|..:..|:                       .|..|  |:.|
  Fly  1263 ---CSHP--YGIGCGSR---KPKDVRKCCHI-----------------------KYTSD--WTDC 1294

  Fly   551 SVTCGEGIRRRTYNCKIFLEYSRTV-------ATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFD 608
            ||.||||::|:..:|.  ..|...|       ..|::|.|..:|.|....|.....|.
  Fly  1295 SVQCGEGVKRKKQSCT--RVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCR------- 1350

  Fly   609 DQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPE 673
                                                     |||
  Fly  1351 -----------------------------------------INC--------------------- 1353

  Fly   674 ARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMC-PQPPPAD 737
                         :||.||:..|...|....:||:|:|   .:..||.   |.:..| .:..|:.
  Fly  1354 -------------KWNASDWRRCPADCSEEYQTRDVRC---ESFQGDG---VEDKHCDAKKRPSK 1399

  Fly   738 RQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPCN 802
            |:.||  :| ||.:....|:|:  | .|.:.|:..|    ...||   ....||:....::..|.
  Fly  1400 RRICN--NC-VRRQSRVISQCN--C-EGVEKRRDFC----FNSHK---GRIACPTRARVERHSCT 1451

  Fly   803 VKPCPPEDPKPVIQINNSTHIQHDPKKTKITL-----KVGGAGLVFFGTQVKIKCPVKRYNRTKI 862
                ||...:....|.:|  |...|:.|.::.     .:||:                 .||...
  Fly  1452 ----PPPHCRRRSAIGSS--ISSRPRGTGVSSSRSLNSIGGS-----------------RNRGTP 1493

  Fly   863 KWSKDHKPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIE---EL 924
            :...|.|.:     :..:|.|..: |::..|...:| || |::|......|...|.:...   |.
  Fly  1494 RSCADLKEM-----HGYNKDGNYQ-LEVRSRMVHIY-CH-GMNSRTPQEYVNVDPQENYSIYYEY 1550

  Fly   925 EQQETERLVREKSGTE----------------------ALTSADMKSADGTGTSTAVG 960
            ..::|.....|..|.|                      .:...|.|.||..|.:..:|
  Fly  1551 RTKQTNSCPPESRGHEYYNDQNSGRTHFRKLRLNITDLRIMDNDFKFADSRGLAQKLG 1608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	18/51 (35%)
		TSP1	546..600	CDD:214559	18/60 (30%)
		TSP1	750..807	CDD:214559	11/56 (20%)
		IGc2	845..902	CDD:197706	10/56 (18%)
		PLAC	1355..1384	CDD:285849
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931	217/1098 (20%)
		TSP1	754..806	CDD:214559	18/51 (35%)
		ADAM_spacer1	937..1042	CDD:283607	0/104 (0%)
		TSP1	1172..1229	CDD:214559	17/56 (30%)
		GON	1495..1687	CDD:285848	24/122 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910