DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and Adamtsl1

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_038967012.1	Gene:	Adamtsl1 / 362539	RGDID:	1306439	Length:	1812	Species:	Rattus norvegicus

Alignment Length:	1885	Identity:	426/1885 - (22%)
Similarity:	633/1885 - (33%)	Gaps:	721/1885 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LNASQAFDDTWNTASDLENELEQQKRSKVQSAGGGGGAGGGPGQWSSWSDWSTCSRTCDGGIMHQ 98
            ||:.:..|.:..||...|:.                     .|.|.:|..||.|||||.||..:.
  Rat    61 LNSHKTEDPSSRTARSEEDR---------------------EGLWDAWGPWSECSRTCGGGASYS 104

  Fly    99 MRRCGSPGSCRGESTRYRICNMQPC-PEQQDFRSSQCSAYNDVPYDGTLYKWTP-HYDYVEPCAL 161
            :|||.|..||.|.:.|||.|:...| ||..|||:.||||:|||.|.|..|:|.| ..|...||:|
  Rat   105 LRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKYHGQFYEWLPVSNDPDNPCSL 169

  Fly   162 TCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGC 226
            .|:....                        |::|:|:.:|.|||||.:.||||||.|.||.|||
  Rat   170 KCQAKGT------------------------SLVVELAPKVLDGTRCYTESLDMCISGLCQIVGC 210

  Fly   227 DLKIGSTKKIDGCGVCGGDGNSCS----------------------------------------- 250
            |.::|||.|.|.||||.|||::|.
  Rat   211 DHQLGSTVKKDNCGVCSGDGSTCRLVRGQYKSQLSASKSDDTVVAIPYGSRHIRLVLKGPDHLYL 275

  Fly   251 ----------------------------------------------------------------- 250

  Rat   276 ETKTLQGTKGENSLSSTGTFLVDNSTVDFQKLPDKEILRMAGPLTADFIVKIHDLGPADSTVQFI 340

  Fly   251 --QPLFN-WEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSV---TNRPEASVEQCNTH 309
              ||:.: |.......||.|||.||:::...|.:..::..|.|..|..   ..:|:..:::||..
  Rat   341 FYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSSRVVADQYCQYYPENIKPKPKLQECNLD 405

  Fly   310 SCP-----------------PRWIADDWSTCSRLCGHGYRERMVVCAEES-NGIKTRVADIMCR- 355
            .||                 |||.|..|:.||..||.|.:.|.|.|.||. .|..|.|.:..|.
  Rat   406 PCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMY 470

  Fly   356 TPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCS 420
            |||.|..:.|.|.:||.|..::|:.|:|:||||::.|.|.|....|..:..|...|||...::|.
  Rat   471 TPKMPVVQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSAKTKPHIKEECI 535

  Fly   421 TGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEG 485
            ....|
  Rat   536 IPTPC------------------------------------------------------------ 540

  Fly   486 LSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSL--DPTYIKDNEWS 548
                     |..|.:..:..:.|               .|.:.::..||.::  :|::|.: .||
  Rat   541 ---------YKPREKLPIEAKLP---------------WFKQAQELEEGAAVSEEPSFIPE-AWS 580

  Fly   549 PCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPC------MLPSHGF 607
            .|:||||.|.:.||..|::.|.:|::||.:....|||.||..: ..|...||      ..|.:|
  Rat   581 ACTVTCGMGTQVRTIRCQVLLPFSQSVADLPADECEGPKPASQ-RACYAGPCNGETPEFNPDNG- 643

  Fly   608 DDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKP 672
                  |.:..|:.:..:.|.|..:|:|.||.||.|||:|.:::|:.:....:....||....:|
  Rat   644 ------DGLLGGLQDLDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTRELADENLCVTSRRP 702

  Fly   673 EARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPAD 737
            ...:::||..|||.||....::|||.:||:|::||:|.|.|.::|..:..:|:.:.:|..|.|:.
  Rat   703 PQLLKSCNLDPCPARWEVGKWSPCSLTCGVGLQTRDVICSHLLSREMNEVVVLADELCHHPKPST 767

  Fly   738 RQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPCN 802
            .|.||..:||..|...:|..||.|||.|.:.|.|.|||.||....:|.||:.|.::||..::.|.
  Rat   768 VQACNRFNCPPAWYPAQWQLCSRTCGGGIQKRDVLCKQRMADGSFLELPETFCSASKPTSQQVCK 832

  Fly   803 VKPCPPE----D-----------------------PKPVIQINNST------------------- 821
            ...||.|    |                       ...|..:.|||
  Rat   833 KDDCPSEWLLSDWSECSVSCGEGTQTRSAICQRMLKTGVSTVVNSTLCPPLPFSSSIRPCMLATC 897

  Fly   822 ------HIQHDP-------------KKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKD 867
                  ..:|.|             ::.|:...|||...:...|.|.::||.:|:.:..|.|.||
  Rat   898 ARPGRPTTKHGPHIAAARNIYIQTRRQRKLHFVVGGFAYLLPKTTVVLRCPTRRFRKPLITWEKD 962

  Fly   868 HKPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAG------------------------LSSAE 908
            .:....|....|:..|.|:|..:...|||:|:|.||                        .|..|
  Rat   963 GQHSISSAHVTVAPFGYLKIHRLKPSDAGIYTCSAGPAREQFVIKLIGGNRKLVARPLSLWSEEE 1027

  Fly   909 ISIEVK------------------------------AKPG------------------------- 918
            .:::|:                              |.||
  Rat  1028 EALQVRKPNPKEALQTHKHQNGIFSNGSKAEKRGLTADPGNRYDDIVSRLLEQGGWPGELLASWE 1092

  Fly   919 -------------------------------------------QQIEELEQQETERLVREKSG-- 938
                                                       ||.|||....::.||.:.:.
  Rat  1093 IQDSAERNASSEEDPNAEQALLHLPFTMVAEQKRLDDILRNLSQQPEELRDLYSKHLVAQLAQDI 1157

  Fly   939 -TEALTSADM--KSADGTGTSTAVGPNSHV--------NGSAQQHGSRRR--------------Q 978
             ...|.:.||  |.::......|:.|:.||        :.|.:..|..||              |
  Rat  1158 FRSHLENQDMLHKPSEQRFPPMAIPPHKHVSSFSSSLRSSSGEAGGGSRRPHRKPTILRKISAAQ 1222

  Fly   979 Q-----------QSERLQNGR-------ERSRRPK--------SDGVQHADSSIME-DDLSQLVQ 1016
            |           |:..|.:|.       |.:..|:        .:.||..|..::: ||..|::
  Rat  1223 QLSASEVVTHLGQTVALASGTLSVLLHCEAAGNPRPAIHWTRNGEAVQFGDRILLQPDDSLQIL- 1286

  Fly  1017 SEDRIPQPASASSG----------------------------------------------GSRTR 1035
                  .|..|..|                                              |...|
  Rat  1287 ------APVEADVGFYTCNATNALGYDSVSIAVTLAGKPLVKTSRMTVLNTEKPTVTVDIGGTVR 1345

  Fly  1036 TL----LAMPYFQALLSNLQLLWPLQRFKDSRGQHLLQGEALKFGIDLSGKDF----------DQ 1086
            |:    :.:....|.:...::.|...:.|.....||.:|..|...:..|.:..          :|
  Rat  1346 TIQRVNVTINCQVAGVPEAEVTWFRNKSKLGSSHHLHEGSLLLTNVSFSDQGLYSCRAANLHGEQ 1410

  Fly  1087 DESER---VPAEQLP-----------------PEVLHSP------SDPEYHE----PSKSGPEAD 1121
            .||.:   :...|:|                 |.||.||      .||....    |.|..|..:
  Rat  1411 TESTQLLILDPPQVPTQLEDIRALLLATGPNLPSVLMSPLGTQLVLDPGNSALLGCPIKGHPTPN 1475

  Fly  1122 VP--------HVPPHMPHARWETGA---------------------AAST--------------- 1142
            :.        ...|.:.|..|..|.                     .|.|
  Rat  1476 ITWFQNGQPIATAPELTHHIWGAGQILHVANLSGGPQGEFSCLAQNEAGTLVQKASLVIQDYWWS 1540

  Fly  1143 -----TAVPSLPNDGFVY--------------------------------------RWMLGEWSQ 1164
                 |...|..|.| |:                                      |||:..||.
  Rat  1541 VDRLATCSASCGNRG-VHQPRLKCLLNNTEVDPEHCAGKPRPAVQLVACNRRDCPSRWMVTSWSA 1604

  Fly  1165 CSQECGAAGSGLQRRTVSCQRAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQSCGNEACPQ 1229
            |::.|   |.|:|.|.|:||   |..:||.::...|::.....      :.|...|:|..:.|.:
  Rat  1605 CTRSC---GGGVQTRRVTCQ---KLKASGISTPVSNDMCTQLS------KRPVDTQACNQQLCVE 1657

  Fly  1230 WSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNG--TEGSICDEYERPAMRQECYNERCEGVWRVE 1292
            |:...|..| ...|.|...|:|.|:|.|:..:|  .....|....||...|.|::|.|...|||.
  Rat  1658 WAFSSWGQC-NGPCIGPRLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRVS 1721

  Fly  1293 PWSECNAPCGRKGIKYRILQCVWYGSRRPA-GNVCKHQPRPAVMKVCKSPACQAQLSSSPAQLCR 1356
            .|:.|.|.||..|.:.|.::||...:.:.. .::|...||||..:.|....|:.....|....|:
  Rat  1722 LWTLCTATCGNYGFQSRRVECVHVRTNKAVPEHLCSWGPRPANWQRCNITPCENSTFQSQRTFCK 1786

Fly 1357 1356
Rat 1787 1786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	23/46 (50%)
		TSP1	546..600	CDD:214559	21/53 (40%)
		TSP1	750..807	CDD:214559	22/56 (39%)
		IGc2	845..902	CDD:197706	19/56 (34%)
		PLAC	1355..1384	CDD:285849	1/2 (50%)
Adamtsl1	XP_038967012.1	TSP1	84..130	CDD:214559	22/45 (49%)
		TSP1_ADAMTS	349..407	CDD:408800	15/57 (26%)
		TSP1_ADAMTS	428..485	CDD:408800	23/56 (41%)
		TSP1_ADAMTS	488..540	CDD:408800	17/51 (33%)
		TSP1_ADAMTS	574..631	CDD:408800	22/58 (38%)
		TSP1_ADAMTS	659..714	CDD:408800	17/54 (31%)
		TSP1_ADAMTS	718..776	CDD:408800	20/57 (35%)
		TSP1_ADAMTS	780..836	CDD:408800	22/55 (40%)
		TSP1_ADAMTS	840..897	CDD:408800	5/56 (9%)
		IGc2	939..997	CDD:197706	19/57 (33%)
		Ig strand B	943..947	CDD:409353	1/3 (33%)
		Ig strand C	956..960	CDD:409353	1/3 (33%)
		Ig strand E	978..982	CDD:409353	2/3 (67%)
		Ig strand F	992..997	CDD:409353	2/4 (50%)
		Ig	<1245..1305	CDD:416386	11/66 (17%)
		Ig strand B	1245..1251	CDD:409353	0/5 (0%)
		Ig strand C	1259..1263	CDD:409353	0/3 (0%)
		Ig strand D	1277..1280	CDD:409353	0/2 (0%)
		Ig strand E	1281..1286	CDD:409353	2/4 (50%)
		Ig strand F	1294..1302	CDD:409353	1/7 (14%)
		Ig	1336..1418	CDD:416386	14/81 (17%)
		Ig strand B	1352..1356	CDD:409353	0/3 (0%)
		Ig strand C	1365..1369	CDD:409353	0/3 (0%)
		Ig strand E	1384..1388	CDD:409353	1/3 (33%)
		Ig strand F	1398..1403	CDD:409353	0/4 (0%)
		Ig	1443..1534	CDD:416386	16/90 (18%)
		Ig strand A	1443..1446	CDD:409353	1/2 (50%)
		Ig strand A'	1453..1456	CDD:409353	0/2 (0%)
		Ig strand B	1462..1469	CDD:409353	1/6 (17%)
		Ig strand C	1475..1480	CDD:409353	0/4 (0%)
		Ig strand C'	1483..1485	CDD:409353	0/1 (0%)
		Ig strand D	1491..1495	CDD:409353	1/3 (33%)
		Ig strand E	1497..1504	CDD:409353	1/6 (17%)
		Ig strand F	1513..1521	CDD:409353	0/7 (0%)
		Ig strand G	1524..1534	CDD:409353	1/9 (11%)
		TSP1_ADAMTS	1597..1655	CDD:408800	20/69 (29%)
		TSP1_ADAMTS	1658..1714	CDD:408800	17/56 (30%)
		TSP1_ADAMTS	1718..1773	CDD:408800	18/54 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10011
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1345
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D26058at33208
OrthoFinder	1	1.000	-	-		FOG0004452
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106353
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970