DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and loh

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster

Alignment Length:	950	Identity:	189/950 - (19%)
Similarity:	298/950 - (31%)	Gaps:	375/950 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VNMNWTSPK---IWAALFVTTLCLLDTQ--------AAWAKKLNASQAFDDTWNTASDLENELEQ 56
            :::|.|:|.   ..:.|..|||..:.|:        |...:.....:.|... |...:..:...:
  Fly   107 ISLNATNPSTSTFKSVLETTTLPSVTTKDLFESGNVATTRQTPKVEEVFSSP-NPPQEATSSTSK 170

  Fly    57 QKRSKVQSAGGGGGAGGGPGQWSSWSDWSTCSRTCDGGIMHQMRRC----------GSPGSCRGE 111
            :.:.||...          .:|..|||||:|||:|.||:.:|:|:|          .:..:|.|.
  Fly   171 KAKKKVYPY----------PRWDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGY 225

  Fly   112 STRYRICNMQPCPEQQ-DFRSSQCSAYNDVPYDGTLYKWTPHYDYVEPCALTCRGHPAHLVEDIS 175
            ..||::||..||.||. |||:||||||||..:.|..|:|.|:......|.|.|..........::
  Fly   226 FKRYQLCNDVPCDEQSPDFRASQCSAYNDKEFHGHRYRWEPYVKDDAECELNCMPFGMKSFATLN 290

  Fly   176 RETGDGN--AEEAEHY-----------DEQSVIVQLSARVQDGTRCRSGSLD----MC--IQGKC 221
            ....||.  ...||::           |.....||.|..: ||....|||:.    :|  :.|..
  Fly   291 ESVIDGTPCGHPAEYFRSQFWERAVCVDGACKAVQASGEI-DGLYAHSGSVSCGGLLCRPVTGIF 354

  Fly   222 QR---------------VGC------DLK-------------------------------IGST- 233
            .|               ||.      :||                               :|:.
  Fly   355 TRNPLPEHAYIHVTTLPVGASNISITELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVF 419

  Fly   234 --KKIDGCGVCGG---------------------------------------------------- 244
              .:|||.....|
  Fly   420 DYHRIDGAEDSNGVTEWITSIGPIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSD 484

  Fly   245 --------DGNSCS------QPLFNWEMAPMSQCSVTCGSGYK--MSRPICRNRLTNADVDDTLC 293
                    |.:|.|      :.:|||::...|.|:.:||.|.:  :.|.|.:|.|..  .....|
  Fly   485 GLLRSGMEDTSSSSSSRAGRKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRY--YSQRRC 547

  Fly   294 SVTNRP--EASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEE-SNGIKTRVADIMCR 355
            :.:.:|  ..::..|||..||..|..|||..|......|.|.|.|.|.:| ::|:...|....|.
  Fly   548 THSVKPVLNENLLHCNTQPCPAYWRFDDWGECRCSSSGGLRRREVSCVQELASGLVIHVDKAACM 612

  Fly   356 TPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCS 420
            ..:||.|:.|   |||.
  Fly   613 EDQPPMQKQC---ECPK------------------------------------------------ 626

  Fly   421 TGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEG 485
                                    |.|
  Fly   627 ------------------------NRR-------------------------------------- 629

  Fly   486 LSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSP- 549
                        |..||.....|.|         :|:|:......:.:|......::. ::|:.
  Fly   630 ------------RNLSRYRLSGPSE---------SSSNSSQVKRSKIDGSDATAIWLV-SDWNQY 672

  Fly   550 CSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRD 614
            ||||||.|:..||    :|.:.|:    ..:..|:.....:....|.:..|.|..
  Fly   673 CSVTCGSGVEYRT----VFCDRSK----AGEQRCDPSTTPESRRPCEKPACELGD---------- 719

  Fly   615 SIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTC 679
                          |....::||:..|........:.|:|..  .:.....|:||.||:: |..|
  Fly   720 --------------WFTGPWSSCNGDCFDLTRTREVLCIRSQ--LITEHSECTPELKPQS-VEKC 767

  Fly   680 NDRP---CPPRWNYSDYTPCSKSCGIGIKTREVQCI-HEVTRGGDNTMVVPNSMC--PQPPPADR 738
            :...   |..||:|||::.|:|.||.|.:.|.|:|: :::....    :..::.|  ....|..|
  Fly   768 SHEEVEYCAARWHYSDWSECTKPCGGGTQRRSVRCLEYDIKMNA----LRESTHCRYTNREPIYR 828

  Fly   739 QYCNVLDC---------PV---RWEVGEWSKCSHTCGYGF 766
            . |||..|         ||   ::...:|:..:..|.|.:
  Fly   829 N-CNVQACAEVPKTEVTPVCADKFSNCQWASQAKLCSYDY 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	22/55 (40%)
		TSP1	546..600	CDD:214559	14/54 (26%)
		TSP1	750..807	CDD:214559	3/16 (19%)
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
loh	NP_609406.2	TSP1	182..238	CDD:214559	22/55 (40%)
		ADAM_spacer1	348..468	CDD:283607	11/119 (9%)
		TSP1	667..716	CDD:214559	14/56 (25%)
		TSP1	779..835	CDD:214559	18/60 (30%)
		PLAC	847..877	CDD:285849	3/20 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910