DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nolo and Adamts3

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_808540.2	Gene:	Adamts3 / 330119	MGIID:	3045353	Length:	1204	Species:	Mus musculus

Alignment Length:	1021	Identity:	215/1021 - (21%)
Similarity:	329/1021 - (32%)	Gaps:	408/1021 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 WNTASDLENELEQQKRSKVQSAGGGGGAGGGPGQWSSWSDWSTCSRTCDGGIMHQMRRCGSP--- 105
            |..|:       |||:.               |.|.||:.:.:|||||..|:..:.|:|.:|
Mouse   542 WKNAN-------QQKQD---------------GNWGSWTKFGSCSRTCGTGVRFRTRQCNNPTPI 584

  Fly   106 ---GSCRGESTRYRICNMQPCPEQ-QDFRSSQCSAYND-VPYDGTLYKWTPHY--DYVEPCALTC 163
               ..|.|.:..|::||.:.|.:. :|||:.||...|. ..|..|.:.|.||.  |..:.|.|.|
Mouse   585 NGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYC 649

  Fly   164 RGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLSARVQDGTRCR-SGSLDMCIQGKCQRVGCD 227
            :          |:||||              :..:...|.|||||. .....:|::|:|.:||||
Mouse   650 Q----------SKETGD--------------VAYMKQLVHDGTRCSYKDPYSICVRGECVKVGCD 690

  Fly   228 LKIGSTKKIDGCGVCGGDGNSCSQPLFNWEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTL 292
            .:|||.|..|.|||||||.:.|
Mouse   691 REIGSNKVEDKCGVCGGDNSHC------------------------------------------- 712

  Fly   293 CSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTP 357
                                 |.:...::...|..|                 |||.|.::   |
Mouse   713 ---------------------RTVKGTFTRTPRKLG-----------------KTRGAFVL---P 736

  Fly   358 KPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTG 422
            |.                          .:.|.:  .|.:.|...|:.|
Mouse   737 KG--------------------------ARNISL--AETRETKNVLAIK---------------- 757

  Fly   423 IHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNE-DENDEGDDVDDLESGQDTDDGEGL 486
                   |:..|..|      ||.:.|.....:..|...| |.|.|    ||:|
Mouse   758 -------NQATGHYI------LNGKGEEAKSRTFIDLGVEWDYNIE----DDIE----------- 794

  Fly   487 SYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYI----KDNEW 547
                                      |:|                ::||..||..:    ::|:
Mouse   795 --------------------------TLH----------------TDGPLHDPVIVLIIPQEND- 816

  Fly   548 SPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFP 612
                       .|.:...| ::.:..:|.|:|.:..
Mouse   817 -----------TRSSLTYK-YIIHEDSVPTINSNNV----------------------------- 840

  Fly   613 RDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVR 677
                   :.|...|:.|..:.::.||..|.||.:.....|.|:.:.::|....|....||:...|
Mouse   841 -------IQEELDTFEWALKSWSQCSEPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIRR 898

  Fly   678 TCNDRPCP-PRWNYSDYTPCSKSCG-IGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQY 740
            .||.:.|. |.|...::..||:||| .|.:.|.|:|:..:..|.:.:  |.:..|....|..|:.
Mouse   899 MCNIQECTHPVWAADEWEHCSRSCGSSGNQLRTVRCLQPLQDGTNRS--VHSKYCLGDRPESRRP 961

  Fly   741 CNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPCNVKP 805
            ||.:.||.:|:.|.|::||.|||.|.:.|:|.|:   ..:|        |...||...:||.:.|
Mouse   962 CNRVPCPAQWKTGSWNECSVTCGEGTEVRQVLCR---TGDH--------CDGEKPESVRPCQLPP 1015

  Fly   806 CPPEDPKPVIQINNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIK-CPVKRYNRTKIKWSKDHK 869
            |..|   |.:                      |...:|...:|..: |.:..||:...:
Mouse  1016 CNDE---PCL----------------------GDKSIFCQMEVLARYCSIPGYNKLCCE------ 1049

  Fly   870 PLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQETERLVR 934
                    ..||:            :|.........:|||..:....|......|.....  .:.
Mouse  1050 --------SCSKR------------SGTLPPPYLQEAAEIHSDAIFGPSDLPRSLVMPTP--FLP 1092

  Fly   935 EKSGTEALTSADMKSADGTGTSTAVGPNSHVNGSAQQHGS----RRRQQQSERLQNGRERSRRPK 995
            ..|||.    |:.||.  :..|:...||:.....|....|    |:|..|:     ||:......
Mouse  1093 SSSGTR----AEKKSL--SSFSSMANPNADAAFRASSRASADFPRKRAHQA-----GRKTLESVP 1146

  Fly   996 SDGVQHADSSIMEDDL---SQLVQSEDRIPQPASASSGGS--RTRT 1036
            |      .|||..|.|   |.:..:    |.||.:.|.|:  :|||
Mouse  1147 S------SSSIKTDHLRPASPVAAA----PSPAISDSIGASPQTRT 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	17/51 (33%)
		TSP1	546..600	CDD:214559	5/53 (9%)
		TSP1	750..807	CDD:214559	19/56 (34%)
		IGc2	845..902	CDD:197706	7/57 (12%)
		PLAC	1355..1384	CDD:285849
Adamts3	NP_808540.2	Pep_M12B_propep	66..200	CDD:279848
		ZnMc_ADAMTS_like	256..457	CDD:239801
		Reprolysin	258..460	CDD:279729
		TSP1	554..605	CDD:214559	17/50 (34%)
		ADAM_spacer1	713..828	CDD:283607	37/261 (14%)
		TSP1	914..968	CDD:214559	16/55 (29%)
		TSP1	971..1016	CDD:214559	18/55 (33%)
		PLAC	1024..1052	CDD:285849	5/41 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900