DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and Adamts7

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_001040566.1	Gene:	Adamts7 / 315879	RGDID:	1306713	Length:	1808	Species:	Rattus norvegicus

Alignment Length:	1464	Identity:	323/1464 - (22%)
Similarity:	461/1464 - (31%)	Gaps:	562/1464 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP-----GS-CRGESTRYRICNMQPC-PEQQDFRSSQ 133
            |.||.||.||.|||:|..|:....|:|..|     |. |.||..|||:||:|.| |::..||.:|
  Rat   734 GGWSGWSAWSVCSRSCGVGVRSSERQCTQPVPKNKGKYCVGERKRYRLCNLQACPPDRPSFRHTQ 798

  Fly   134 CSAYNDVPYDGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQL 198
            ||.::.:.|.|.|:||.|..:...||.|.||..                     :|..:.   :|
  Rat   799 CSQFDSMLYKGKLHKWVPVLNDENPCELHCRPF---------------------NYSNRE---KL 839

  Fly   199 SARVQDGTRCRSG--SLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFNWEMAPM 261
            ...|.|||.|..|  |.|:||.|.|::||||.::.|..:.|.||||.|||::|......::.|.
  Rat   840 RDAVMDGTPCYQGRISRDICIDGICKKVGCDFELDSGAEEDRCGVCRGDGSTCHTVSRTFKEAE- 903

  Fly   262 SQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRL 326
                   |.||             .||.                                    |
  Rat   904 -------GMGY-------------VDVG------------------------------------L 912

  Fly   327 CGHGYRERMV-VCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPH-------WEVEDWTGCSV 383
            ...|.||.:: ..||.:|.:..|..|                   |.       |.:: |.|
  Rat   913 IPAGAREILIEEVAEAANFLALRSED-------------------PDKYFLNGGWTIQ-WNG--- 954

  Fly   384 SCGQGIQMRGVECKSTDGSLSAKCDPLTKPGS----------MQQCSTGIHCGGSLNKVGGTIIV 438
                ..|:.|.....|   .....:.||.||.          .|:.:.|:|
  Rat   955 ----DYQVAGTTFTYT---RKGNWETLTSPGPTTEPVWIQLLFQERNPGVH-------------- 998

  Fly   439 GSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRL 503
                                                                    |.:..|...
  Rat   999 --------------------------------------------------------YKYTIQRAS 1007

  Fly   504 NQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIF 568
            :.||.....:.|.                 ||           ||.|.||||.|::|::..|
  Rat  1008 HSEAQPPEFSWHY-----------------GP-----------WSKCPVTCGTGVQRQSLYC--- 1041

  Fly   569 LEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQG 633
                                   :|:                      :.|:.:.|.
  Rat  1042 -----------------------MEK----------------------QAGIVDEGH-------- 1053

  Fly   634 YTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSK 698
                                            |...::|..|.|.||:.|||.||...|:.|||:
  Rat  1054 --------------------------------CDHLSRPRDRKRKCNEEPCPARWWVGDWQPCSR 1086

  Fly   699 SCGI-GIKTREVQCIHEVTRGGDNTMVVPNSMCPQ-PPPADRQYC-NVLDCPVRWEVGEWSKCSH 760
            |||. |...|.|.|...|  |.|....:..|.|.. |.|.....| :.:.||..|.||.||:||.
  Rat  1087 SCGPGGFFRRAVFCTRSV--GLDEQRALEPSACGHLPRPLAEIPCYHYVACPSSWGVGNWSQCSV 1149

  Fly   761 TCGYGFKDRKVECKQIMAQEHKIERPESMCPSA-KPADKKPCNVKPC------------------ 806
            |||.|.:.|.|.|         |......|..| :|..:..|.::||
  Rat  1150 TCGAGIRQRSVLC---------INNTGVPCDGAERPITETFCFLQPCQYSTYIVDTGASGSGSSS 1205

  Fly   807 -------------------PPEDPKPVIQINNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIKC 852
                               |...|||| .|:|:.. :.||       ::...|.||.....
  Rat  1206 PELFNEVDFDPHQPVPRPSPASSPKPV-SISNAID-EEDP-------ELDPPGPVFVDDFY---- 1257

  Fly   853 PVKRYNRTKIKWSKD-----------------------H-KPLQRSRKYKVSKKGALRILDITFR 893
                |:...|.:.:|                       | :|.:......|...||....:...:
  Rat  1258 ----YDYNFINFHEDLSYGSFEESHSDLVDIGGQTVPPHIRPTEPPSDSPVPTAGAPGAEEEGIQ 1318

  Fly   894 DAGVYSCHAGLSSAEIS--IEVKAKPGQQIEELEQQETERLVREKSGTEALTSADMKSADGTGTS 956
              |.:|....||.|..|  :.::..|...:.....:|...:...:.|..:: |....|.||..||
  Rat  1319 --GSWSPSPLLSEASHSPPVLLENTPVNPLANFLTEEESPIGAPELGLPSV-SWPPASVDGMVTS 1380

  Fly   957 TAVG-PNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSSIMEDDLSQLVQSEDR 1020
            .|.| |:..:         .|...||:......:|::..| ||          :.|.....:..:
  Rat  1381 VAPGNPDELL---------VREDTQSQPSTPWSDRNKLSK-DG----------NPLGPTSPALPK 1425

  Fly  1021 IPQPASASSGGSRTRTLLAMPYFQALLSNLQLLWPLQRFKDSRGQHLLQGEALKFGIDLSGKDFD 1085
            .|.|...||..:.|.        ||.||.       ...:.|.|.::.....|
  Rat  1426 SPFPTQPSSPSNSTT--------QASLSP-------DAVEVSTGWNVALDPVL------------ 1463

  Fly  1086 QDESERVPAEQLPPEVLHSPSDP----EYHEPSKSGPEADVPHVPPHMPHARWETGAAASTTAV- 1145
              |::..|        :|:|:||    :...|...|.::     |..:|....||...:|....
  Rat  1464 --EADLKP--------VHAPTDPGLLDQIQTPHTEGTQS-----PGLLPRPAQETQTNSSKDPAV 1513

  Fly  1146 ----PSLPNDGFV--------YRWMLGEWSQCSQECGAAGSGLQRRTVSCQ-------------- 1184
                |||..||..        ..|.:|.|||||..||.   |...|.|.|.
  Rat  1514 QPLQPSLVEDGAPTDLLPAKNASWQVGNWSQCSTTCGL---GAIWRLVRCSSGNDEDCTLSSRPQ 1575

  Fly  1185 -------RAAKATSSGSTSDTENNVVDNS-----ECF-------------AHGLELPEFFQSCGN 1224
                   |...|..:|:.|....|....|     :|.             ..|...|...|.||.
  Rat  1576 PARHCHLRPCAAWRAGNWSKCSRNCGGGSATRDVQCVDTRDLRPLRPFHCQPGPTKPPTRQLCGT 1640

  Fly  1225 EACPQWSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNGTEGSICDEYERPAMRQECYNERCEGVW 1289
            :.|..|....|..|..: |.|   ..|:|.|||..|     .:|:|..||...:.|....|. .|
  Rat  1641 QPCLPWYTSSWRECSEA-CGG---GEQQRLVTCPEP-----GLCEESLRPNNTRPCNTHPCT-QW 1695

  Fly  1290 RVEPWSECNAPCGRKGIKYRILQCV--WYGSRRPAGNVCKHQPRPAVMKVCKSPACQAQLSSSPA 1352
            .|.||.:|:|||| .|::.|:::||  ..|......::|.|:..|...:.|.:..|:.   ..|:
  Rat  1696 VVGPWGQCSAPCG-GGVQRRLVKCVNTQTGLAEEDSDLCSHEAWPESSRPCATEDCEL---VEPS 1756

  Fly  1353 QLCRD--SSRYCRNARAMGLCRLHRYKLKCCGSC 1384
            :..||  ...:|...|.:|.|:|...:.:||.||
  Rat  1757 RCERDRLPFNFCETLRLLGRCQLPTIRAQCCRSC 1790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	25/52 (48%)
		TSP1	546..600	CDD:214559	11/53 (21%)
		TSP1	750..807	CDD:214559	21/94 (22%)
		IGc2	845..902	CDD:197706	10/80 (13%)
		PLAC	1355..1384	CDD:285849	9/30 (30%)
Adamts7	NP_001040566.1	Pep_M12B_propep	271..386	CDD:279848
		Reprolysin	436..647	CDD:279729
		ZnMc_ADAMTS_like	436..644	CDD:239801
		ADAM_CR	<690..724	CDD:301627
		TSP1	736..788	CDD:214559	24/51 (47%)
		ADAM_spacer1	894..1004	CDD:283607	30/266 (11%)
		TSP1	1018..1073	CDD:214559	23/170 (14%)
		TSP1	1137..1187	CDD:214559	19/58 (33%)
		TSP1	1591..1643	CDD:214559	10/51 (20%)
		TSP1	1648..1692	CDD:214559	15/52 (29%)
		TSP1	1692..1751	CDD:214559	19/60 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810