DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and Adamts20

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_038936261.1	Gene:	Adamts20 / 315263	RGDID:	1307725	Length:	1928	Species:	Rattus norvegicus

Alignment Length:	1621	Identity:	330/1621 - (20%)
Similarity:	462/1621 - (28%)	Gaps:	711/1621 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVNMNW-TSPKIWAAL-------FVTT---LCLLDTQAAWAKKLN---ASQAFDDT------WN 45
            |:..:|: |||..|:|.       |:.|   .||||........|:   ....:|..      :.
  Rat   429 MAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLLDKPNGRTYDLSPQLPGSVYDGNKQCELMFG 493

  Fly    46 TASDLENELEQQKRSKVQSAGG------------GGGAGGGP--------------------GQW 78
            ..|.:...|:|.:|....||.|            ..|...||                    |:|
  Rat   494 PGSQVCPYLKQCRRLWCTSAEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCVTRDMETRPVDGEW 558

  Fly    79 SSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPCPE-QQDFRSSQCSA 136
            ..|..:|:|||||.|||....|.|..|..      |.|...::|.||...||: ::|||..|||.
  Rat   559 GPWGPYSSCSRTCGGGIRSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCPKGKRDFREKQCSD 623

  Fly   137 YNDVPYD----GTLYKWTPHYDYV---EPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSV 194
            ::...:|    ....:|.|.|..:   :.|.|.||         ::..|.
  Rat   624 FDGKHFDISGLPPNVRWLPKYSGIAVKDRCKLYCR---------VAGTTS--------------- 664

  Fly   195 IVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC---------- 249
            ..||..||.|||.|.:.:.|:|:||.|::.|||..:.|..|.|.|||||||.:||
  Rat   665 FYQLKDRVADGTPCGTETNDICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSCQTLAGVFNSA 729

  Fly   250 -------------------------SQP------------------------------------- 252
                                     .:|
  Rat   730 HYGYNVVVKIPAGATNIEILQHSYSGRPEDDNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVF 794

  Fly   253 --------------------------------------------------LFNWE-MAPMSQCSV 266
                                                              ||:|: ..|...|:.
  Rat   795 EYSGSNNSIERINSTDRLEAELVLQVLCVGNLYNPDVHYIFNIPIEERSNLFSWDPYGPWQDCTK 859

  Fly   267 TCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGY 331
            .| .|....:..|..:...|.|.|..||....|....|:||| .|..||.....|.||..||.||
  Rat   860 MC-QGLHRRKIACIRKSDRAVVSDQSCSHLPLPLFVTERCNT-DCELRWHITGKSDCSSQCGQGY 922

  Fly   332 RERMVVCAEES--NGIKTRVADIMCRTP-KPPTQE----TCIIEECPHWEVEDWTGCSVSCGQGI 389
            |...|.|.:.|  .|....|.|..|... |||.:|    :|::   ..|...:|:.||.|||.|.
  Rat   923 RTLDVHCMKYSVHKGQTVPVGDQYCGDQLKPPNREPCHGSCVL---TRWHYSEWSQCSRSCGGGE 984

  Fly   390 QMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDS 454
            :.|...|                                   |.|
  Rat   985 KTRESYC-----------------------------------VNG-------------------- 994

  Fly   455 SDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNG 519
                                                    :.||...|..||.|      .::.|
  Rat   995 ----------------------------------------FGHRLAERECQELP------RVVLG 1013

  Fly   520 NSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCE 584
            |.|:....|...|             |||.|.||||:|:::|...|:      |:...|.|..|:
  Rat  1014 NCNDFPCPGWATS-------------EWSECPVTCGKGMKQRQVWCQ------RSEDPVGDDFCD 1059

  Fly   585 GKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELI 649
            .....:.:..|....|.                          .|....:.||:.:|..|.:...
  Rat  1060 ASTKPESLGPCELRACA--------------------------SWHVGPWGSCTVTCGHGYQVRA 1098

  Fly   650 INCVREDNGRVVSPFLCSPETKPEARVRTCNDRPC------------------PPRWNYSDYTPC 696
            :.||.|..|.|:....|...::|..| :.|...||                  ..:|.:..:|||
  Rat  1099 VKCVSEILGTVLDDRECPRASRPSDR-QDCIFAPCLAILKVGATSLPAIPLGKAAQWRHGSWTPC 1162

  Fly   697 SKSCGIGIKTREVQC--IHEVTRGGDNTMVVPN----SMCPQPPPADRQYCNVLDCPVRWEVGEW 755
            |.|||.|.:.|.|.|  .|:......|...:|.    |:|..|       |.      .|:.|:|
  Rat  1163 SVSCGRGSQARYVSCRDAHDGVADELNCAHLPRPAEVSLCFSP-------CG------EWQAGDW 1214

  Fly   756 SKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMC-PSAKPADKKPCNVKPCPPEDPKPVIQINN 819
            |.||.:||:|...|:|.|    ...|::. .||.| |..:|..::.|.:..|||...:   ..::
  Rat  1215 SPCSASCGHGKTTRRVLC----VNYHQLV-DESYCDPEGRPVTEQECRLAACPPSYSR---SPSS 1271

  Fly   820 STHIQHDPKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGA 884
            |....|.|                 |..|.:                .|||.:..
  Rat  1272 SEQPSHGP-----------------GRNVPL----------------THKPEENP---------- 1293

  Fly   885 LRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSADMKS 949
                     |.||          ::||.
  Rat  1294 ---------DQGV----------QLSIR------------------------------------- 1302

  Fly   950 ADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSSIMEDDLSQL 1014
                |.....||....:.|.                          :.|:||.         :.:
  Rat  1303 ----GNQWRTGPWGACSRSC--------------------------AGGLQHR---------AVV 1328

  Fly  1015 VQSEDRIPQPASASSGGSRTRTLLAMPYFQALLSNLQLLWPLQRFKDSRGQHLLQGEALKFGIDL 1079
            .|.||          |.|.|
  Rat  1329 CQDED----------GRSAT--------------------------------------------- 1338

  Fly  1080 SGKDFDQDESERVPAEQLPPEVLHSPSDPEYHEPSKSGPEADVPHVPPHMPHARWETGAAASTTA 1144
                       ...|...|||..|..|.|
  Rat  1339 -----------SCEATSKPPESKHCGSGP------------------------------------ 1356

  Fly  1145 VPSLPNDGFVYRWMLGEWSQCSQECGAAGSGLQRRTVSCQRAAKATSSGSTSDTENNVVDNSECF 1209
               .|      :|..|:|.:|:|.|||   |::.|.|.||                 ..|.....
  Rat  1357 ---CP------QWNYGDWGECTQTCGA---GVKSRFVICQ-----------------FPDGQMAQ 1392

  Fly  1210 AHGLELPE--FFQSCGNEACP---QWSKGDWTPCQRSHCHGRNTAMQRREVTC--RYPNGTEGSI 1267
            .|..|||:  ....|...|||   .|.:|.|..|..|...|    ::.|||.|  :.....|...
  Rat  1393 EHSCELPKPPSMMQCHLRACPDDVSWYRGSWKSCSASCGKG----IKYREVLCIDQVQRKLEEKY 1453

  Fly  1268 CDEYERPAMRQECYNERCEGVWRVEPWSECNAPCGRKGIKYRILQCVWYGSRRPAGNVCKHQPRP 1332
            |....:|...:.|.:.||.. |:...|.||:..|| .|::.|.:.|...|:.|.|.::|:...||
  Rat  1454 CSHLHKPRTHKPCRSGRCPS-WKANKWKECSVTCG-SGVQQREVYCRLRGTGRVAEDMCEPSTRP 1516

  Fly  1333 AVMKVCKSPACQAQLSSSPAQLCRDSSRYCRNARAMGLCRLHRYKL-KCCGSCEQQPNQHL 1392
            .|.:.|....|.....::...|  |.|..|:        :...|:| ||......|.|:.|
  Rat  1517 QVQRPCWHQDCTRYQWTTGDWL--DCSTSCK--------KKETYRLVKCVNERNMQVNESL 1567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	19/51 (37%)
		TSP1	546..600	CDD:214559	16/53 (30%)
		TSP1	750..807	CDD:214559	19/57 (33%)
		IGc2	845..902	CDD:197706	8/56 (14%)
		PLAC	1355..1384	CDD:285849	7/29 (24%)
Adamts20	XP_038936261.1	Pep_M12B_propep	41..186	CDD:396235
		ZnMc_ADAMTS_like	257..463	CDD:239801	10/33 (30%)
		ADAM_CR_2	478..545	CDD:407643	11/66 (17%)
		TSP1	558..610	CDD:214559	19/51 (37%)
		ADAM_spacer1	720..838	CDD:368694	1/117 (1%)
		TSP1_ADAMTS	906..959	CDD:408800	20/52 (38%)
		TSP1_ADAMTS	968..1020	CDD:408800	21/152 (14%)
		TSP1_ADAMTS	1023..1075	CDD:408800	17/70 (24%)
		TSP1_ADAMTS	1078..1132	CDD:408800	14/54 (26%)
		TSP1_ADAMTS	1154..1206	CDD:408800	18/58 (31%)
		TSP1_ADAMTS	1209..1261	CDD:408800	19/56 (34%)
		TSP1_ADAMTS	1306..1357	CDD:408800	19/190 (10%)
		TSP1_ADAMTS	1360..1412	CDD:408800	19/71 (27%)
		TSP1_ADAMTS	1418..1471	CDD:408800	14/56 (25%)
		TSP1_ADAMTS	1474..1527	CDD:408800	17/53 (32%)
		TSP1_ADAMTS	1532..1585	CDD:408800	11/46 (24%)
		TSP1_ADAMTS	1657..1708	CDD:408800
		GON	1713..1880	CDD:400843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910