DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nolo and Adamtsl2

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_038962070.1	Gene:	Adamtsl2 / 311827	RGDID:	1305459	Length:	957	Species:	Rattus norvegicus

Alignment Length:	1186	Identity:	217/1186 - (18%)
Similarity:	302/1186 - (25%)	Gaps:	653/1186 - (55%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QAAWAKKLNA----------SQAFDDTWNTASDLENELEQQKRSKVQSAGGGGGAGGGPGQWSSW 81
            ::.||..|.|          ::|.|:     |...|.||             |||......|..|
  Rat     7 RSRWAWSLLAMAVVAGGAASTEASDN-----SPTSNSLE-------------GGADATAYWWGEW 53

  Fly    82 SDWSTCSRTCDGGIMHQMRRC------GSPG----SCRGESTRYRICNMQPC-PEQQDFRSSQCS 135
            :.|:.|||:|.||:..|.|.|      ..||    :|.|.|.||::|.:|.| |:.:.||..||.
  Rat    54 TKWTACSRSCGGGVTSQERHCLQQRRKSVPGAGNRTCVGTSKRYQLCRVQECPPDGRSFREEQCV 118

  Fly   136 AYNDVPYDGTLYKWTPHY--DYV----EPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSV 194
            ::|...|||..|:|.|.|  ||:    :||.|.|             .|.||..
  Rat   119 SFNSRVYDGRAYQWKPLYPDDYMHISSKPCDLHC-------------TTVDGQR----------- 159

  Fly   195 IVQLSARVQDGTRCRSGSL-DMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCS-------- 250
              ||....:|||.|:...| .:|:.|||:.:|||..:.||..:|.||||.|||:||:
  Rat   160 --QLMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGVCQGDGSSCTHVTGNYRK 222

  Fly   251 ----------------------------------------------------------------- 250

  Rat   223 GDNHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGFYFFNGNYKVDSPKNFNIAGTVVKYR 287

  Fly   251 ----------------------------------------------------------------- 250

  Rat   288 RPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQSPHMHHLPPVYYSFSEAASE 352

  Fly   251 ---------------------------QP------------------------------------ 252
                                       ||
  Rat   353 STESTERQELDSARLLGFLQHNGSLYGQPSSERLGLNSQLFPPTAPEVELGPSRGQETNEVCKQA 417

  Fly   253 ----------------------------------------------------------------- 252

  Rat   418 SGGVCEGPPRGKGFQDHNATGRALLGDKDDREISAHFTSHELLSANTISDQLLGTGSDSEEFSLN 482

  Fly   253 ----------------------------------------------------------------- 252

  Rat   483 ETMNSIFAQGAPRSSPAESLYVDYEENEGPAAYLINGSYLELNSDRINTSSEAPFPNTSASLPSL 547

  Fly   253 -----------------------LFNWEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCS 294
                                   ::.|:::....||.||.:|...:..:| .|....:|||:.|.
  Rat   548 AGNRTHKARTRPKARKQGVSPADMYRWKLSSQEPCSATCTTGVMSAYAMC-VRYDGVEVDDSYCD 611

  Fly   295 VTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEE-SNGIKTRVADIMCRTP- 357
            ...|||...|.|....|.|||....||.|||.||.|::.|:|.|.:. |.|..:.|...:|...
  Rat   612 ALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGHQFRIVRCWKMLSPGFDSSVYSDLCEATE 676

  Fly   358 --KPPTQETCIIEEC-PHWEVEDWTGCSVSCGQ-GIQMRGVECKSTDGSLSAKCDPLTKPGSMQQ 418
              :|..::||....| |.||:.:|:.|:..||: .:..|.:.| |.|..|   |||.|:|...:.
  Rat   677 AVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRC-SEDERL---CDPNTRPVGEKN 737

  Fly   419 CSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDG 483
            | ||..|                       :||...||
  Rat   738 C-TGPPC-----------------------DRQWTVSD--------------------------- 751

  Fly   484 EGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWS 548
                                                                           |.
  Rat   752 ---------------------------------------------------------------WG 753

  Fly   549 PCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPR 613
            |||.:||:|...|...||
  Rat   754 PCSGSCGQGRTIRHVYCK----------------------------------------------- 771

  Fly   614 DSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRT 678
                                 ||                    :||||....|..||||.| :..
  Rat   772 ---------------------TS--------------------DGRVVPESQCQTETKPLA-IHP 794

  Fly   679 CNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMC--PQPPPADRQYC 741
            |.|:.||..|...|:..|:.:||.|:|.|.|.|: |:..|  ...:...|.|  .:.|| :...|
  Rat   795 CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCM-ELANG--KPQMRSGSECGLARKPP-EESTC 855

  Fly   742 NVLDCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPC 806
            ....| .:|....||:|:.|||.|.:.|.|:|.|      ..:......|..||..::.|:::||
  Rat   856 FERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQ------GTDIVRGCDPLVKPVGRQACDLQPC 913

  Fly   807 PPEDPKPVIQINNSTH 822
            |.|.|....|....|:
  Rat   914 PTEPPDDSCQDQPGTN 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	22/56 (39%)
		TSP1	546..600	CDD:214559	10/53 (19%)
		TSP1	750..807	CDD:214559	17/56 (30%)
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
Adamtsl2	XP_038962070.1	TSP1	50..106	CDD:214559	21/55 (38%)
		ADAM_spacer1	216..330	CDD:368694	0/113 (0%)
		TSP1_ADAMTS	632..691	CDD:408800	19/58 (33%)
		TSP1_ADAMTS	695..743	CDD:408800	19/52 (37%)
		TSP1_ADAMTS	747..800	CDD:408800	26/231 (11%)
		TSP1_ADAMTS	804..860	CDD:408800	17/59 (29%)
		TSP1_ADAMTS	863..913	CDD:408800	16/55 (29%)
		PLAC	922..953	CDD:400844	2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900