DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nolo and Adamts8

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_003750503.1	Gene:	Adamts8 / 300475	RGDID:	1308511	Length:	905	Species:	Rattus norvegicus

Alignment Length:	393	Identity:	111/393 - (28%)
Similarity:	153/393 - (38%)	Gaps:	82/393 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPCPEQ-QDFRSSQ 133
            |.|..|..|..|||||.|||....|.|.:|..      |.||..:|:.|..:.||.. :.||..|
  Rat   543 GDWGPWGPWGQCSRTCGGGIQFSNRECDNPAPQNGGRFCLGERVKYQSCKTEECPPNGKSFREQQ 607

  Fly   134 C---SAYNDVPYDGTLYKWTPHYDYVEP---CALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQ 192
            |   :|||....||...:|.|.|..|.|   |.|.||..              |.:|
  Rat   608 CEKYNAYNHTDLDGNFLQWVPKYSGVSPRDRCKLFCRAR--------------GRSE-------- 650

  Fly   193 SVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFNWE 257
              ......:|.|||.|...:|.:|::|:|.:.|||..:.|.||:|.||||||.|.:|.:  .:..
  Rat   651 --FKVFETKVIDGTLCGPDTLAICVRGQCVKAGCDHVVNSPKKLDKCGVCGGKGTACRK--VSGS 711

  Fly   258 MAPMS---QCSVTCGSG------YKMSRPICRN-------------RLTNADV------DDTLCS 294
            ..|.|   ...||..:|      .:.|.|..:|             .|.|.::      .|.|..
  Rat   712 FTPFSYGYNDIVTIPAGATNIDVKQRSHPGVQNDGSYLALKTANGQYLLNGNLAISAIEQDILMK 776

  Fly   295 VT----NRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCR 355
            .|    :...|::|:..:....|..:.....|.|   |..:..::.......|.....|.....|
  Rat   777 GTILKYSGSMATLERLQSFQALPEPLTVQLLTVS---GEVFPPKVKYTFFVPNDTDFNVQSSKER 838

  Fly   356 TPKPPTQETCIIEECPH--WEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQ 418
            .      .|.||:..|:  |.:.||:.|..:||.|.|.|.|||:...|..|..||...||...:.
  Rat   839 A------STNIIQSLPYAEWVLGDWSECPSTCGGGWQRRTVECRDPSGQASDTCDEALKPEDAKP 897

  Fly   419 CST 421
            |.:
  Rat   898 CGS 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	19/51 (37%)
		TSP1	546..600	CDD:214559
		TSP1	750..807	CDD:214559
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
Adamts8	XP_003750503.1	Pep_M12B_propep	49..152	CDD:279848
		Reprolysin	234..444	CDD:279729
		ZnMc_ADAMTS_like	234..441	CDD:239801
		ADAM_CR	463..529	CDD:301627
		TSP1	545..597	CDD:214559	19/51 (37%)
		ADAM_spacer1	706..825	CDD:283607	19/123 (15%)
		TSP1	852..903	CDD:214559	19/49 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11383
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.900