DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and Adamts12

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_001099890.2	Gene:	Adamts12 / 294809	RGDID:	1307323	Length:	1599	Species:	Rattus norvegicus

Alignment Length:	1513	Identity:	328/1513 - (21%)
Similarity:	481/1513 - (31%)	Gaps:	621/1513 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RSKVQSAGGGGGAG------GG------------PGQWSSWSDWSTCSRTCDGGIMHQMRRCGSP 105
            |||:.:|..|...|      .|            ||.|..||.||.|||||..|.....|.|.:|
  Rat   512 RSKLDAAADGTRCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGAQSAERLCNNP 576

  Fly   106 GS------CRGESTRYRICNMQPC-PEQQDFRSSQCSAYNDVPYDGTLYKWTPHYDYVEPCALTC 163
            ..      |.||..|||:||:.|| .:...||..|||.::.|||....|:|.|.::...||.|.|
  Rat   577 EPKFGGKYCTGERKRYRLCNVHPCRSDTPTFRQMQCSEFDTVPYKNQFYRWFPVFNPAHPCELYC 641

  Fly   164 RGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLSARVQDGTRCRSG--SLDMCIQGKCQRVGC 226
            |                       ..|||.....|.| |.|||.|..|  |.::||.|.|:||||
  Rat   642 R-----------------------PIDEQFSERMLEA-VIDGTPCFEGGNSRNVCINGICKRVGC 682

  Fly   227 DLKIGSTKKIDGCGVCGGDGNSCS--QPLFNWEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVD 289
            |.:|.|....|.||||.|||::|.  :.:|..:.          ||||             .|:.
  Rat   683 DYEIDSNATEDRCGVCLGDGSACQTVKKVFRQKE----------GSGY-------------IDIG 724

  Fly   290 DTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMC 354
                                                |...|.|:
  Rat   725 ------------------------------------LIPKGARD--------------------- 732

  Fly   355 RTPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQC 419
                                                :|.:|.|:....|:.:.:...|    ...
  Rat   733 ------------------------------------IRVMEIKAAGNFLAIRSEDPEK----YYL 757

  Fly   420 STG--IHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDD 482
            :.|  |...|:. |:.||:.                          :.|...|::.|.:...|::
  Rat   758 NGGFIIQWNGNY-KLAGTVF--------------------------QYDRKGDLERLMAPGPTNE 795

  Fly   483 -----------GEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPS 536
                       ..|:.|.     |..|.....|    |..:.::..      .|.|
  Rat   796 SVWLQLLFQVTNPGIKYE-----YTVRKDGLDN----DVEKLLYFW------QFGR--------- 836

  Fly   537 LDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCM 601
                      |:.||||||.||||:|
  Rat   837 ----------WTECSVTCGTGIRRQT--------------------------------------- 852

  Fly   602 LPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLC 666
                                                            .:||::.:|.|.:.| |
  Rat   853 ------------------------------------------------AHCVKKGHGIVKTTF-C 868

  Fly   667 SPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCG-IGIKTREVQCIHEVTRGGDNTMVVPNSMC 730
            :|||:|..|.:.|.::.|||||...::..||.:|| .|.|.|.|.||.  |.|.|. ..:|.:.|
  Rat   869 NPETQPSVRQKKCYEKDCPPRWWAGEWEACSMTCGPYGEKKRTVLCIQ--TMGSDE-QALPATDC 930

  Fly   731 PQ-PPPADRQYCN--VLDCPVRWEVGEWSKCSHTCGYGFKDRKVEC-KQIMAQEHKIERPES--- 788
            .. ..|.....||  :| ||..|.||.||:||.:||.|.:.|.|.| |.:.....|..:|.|
  Rat   931 QHLLKPKTLVSCNRDIL-CPSDWTVGNWSECSVSCGGGVRIRSVTCAKNLNEPCDKTRKPNSRAL 994

  Fly   789 ----MCPSAK----------PADKKPC-----NVKPCP--------------------------- 807
                .||.::          |:.|.|.     :.||.|
  Rat   995 CGLQQCPFSRRVLKPNKDTVPSGKNPTTSEHDHFKPIPASTSRPTPLSTPTVPESVSTSTPTINS 1059

  Fly   808 -------PEDPKPVIQINNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWS 865
                   .|:|..:...||||..:.|   :.|...||...          :.|:     |...||
  Rat  1060 LGSTITSQEEPDGIGWQNNSTQAEED---SHIPTSVGSTS----------QTPL-----TSWSWS 1106

  Fly   866 --KDHKPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQE 928
              .|.:.:..|.....|:.           |....:..:||||:              ..:..|.
  Rat  1107 MQPDDENVSSSAIGPTSES-----------DFWATTSDSGLSSS--------------NAMTWQV 1146

  Fly   929 TERLVREKSGTEALTSADMKSADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRR 993
            |...      :.|.|..:::...|:|..:....|...|.|.              |.|   :.|.
  Rat  1147 TPFY------STATTEPEVEIHSGSGEDSDQPLNKEENNSV--------------LWN---KIRV 1188

  Fly   994 PKSDGVQHADSSIMEDDLSQLVQSEDRIPQPASASSGGSRTRTLLAMPYFQALLSNLQLLWPLQR 1058
            |:.|.....|:.|...            |.|.|..:..|      :.|.|..::.:....|   .
  Rat  1189 PERDAPMEMDAEIPLG------------PPPTSYVTEES------SWPPFSTMMKSSLPAW---S 1232

  Fly  1059 FKDS--RGQHLLQGEALKFGIDLSGKDFDQDESERV-PAEQLPPEVLHSPSDPEYHEPSKSGP-- 1118
            ||:.  |.:.::..::....:.|.| |......|:: ..:||......:|:       ..|||
  Rat  1233 FKNETPRDEGMITEKSGNIPLPLGG-DHQTTSPEKLGNNDQLASANSTNPT-------QGSGPVL 1289

  Fly  1119 -EADVPHVPPHMPHARWETGAAASTTAVPSLPNDGFVYRWMLGEWSQCSQECGAAGSGLQRRTVS 1182
             |.|...:        .|.|...:.:....|..|.....|::|.||:||..||.   |...|:|.
  Rat  1290 TEEDASTL--------IEEGFLLNASNYKHLMKDHSPAHWIVGNWSKCSTTCGL---GAYWRSVE 1343

  Fly  1183 CQRAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQSCGNEACPQWSKGDWTPCQRSHCHGRN 1247
            |       |:|.          |::|.|  ::.|:..:.|....|..|..|:|:.|.| :|.|
  Rat  1344 C-------STGM----------NADCAA--IQRPDPAKKCHLRPCAGWRVGNWSKCSR-NCSG-- 1386

  Fly  1248 TAMQRREVTCRYPNGTEGSICDEYER--------------PAMRQECYNERCEGVWRVEPWSECN 1298
             ..:.|||.|.  :|.      ::.|              |.:...|..|.|| .|:|||||:|:
  Rat  1387 -GFKIREVQCM--DGV------DHHRSLRPFHCQFLAGVPPPLSMSCNLEPCE-EWKVEPWSQCS 1441

  Fly  1299 APCGRKGIKYRIL-----QCVWYGSRRPAGNV--------------------------------- 1325
            ..|| .|::.|.:     .|.|  ::|||..|
  Rat  1442 RSCG-GGVQERGVFCPGGLCDW--TKRPASTVPCNRHLCCHWATGNWELCTTSCGGGSQKRTVHC 1503

  Fly  1326 ---------------CKHQPRPAVMKVCKSPACQ--AQLSSSPAQLCRDSSRYCRNARAMGLCRL 1373
                           |.||.||...:.|...||:  |.|:.:..:|   |:.:|:..::|..|.:
  Rat  1504 IPSENSTTEDQDQCFCDHQARPPEFQNCNQQACRKSADLTCTKDRL---STSFCQTLKSMKKCSV 1565

  Fly  1374 HRYKLKCCGSCEQQPNQH 1391
            ...:::||.||.|..:.|
  Rat  1566 PSVRVQCCLSCPQTQSIH 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	24/52 (46%)
		TSP1	546..600	CDD:214559	12/53 (23%)
		TSP1	750..807	CDD:214559	24/79 (30%)
		IGc2	845..902	CDD:197706	8/58 (14%)
		PLAC	1355..1384	CDD:285849	6/28 (21%)
Adamts12	NP_001099890.2	Pep_M12B_propep	80..196	CDD:279848
		Reprolysin	250..460	CDD:279729
		ZnMc_ADAMTS_like	250..457	CDD:239801
		ADAM_CR	519..680	CDD:301627	61/184 (33%)
		TSP1	549..600	CDD:214559	22/50 (44%)
		ADAM_spacer1	706..816	CDD:283607	27/261 (10%)
		TSP1	832..887	CDD:214559	26/167 (16%)
		TSP1	950..1001	CDD:214559	17/50 (34%)
		PARM	1021..>1176	CDD:293666	32/203 (16%)
		TSP1	1429..1477	CDD:214559	19/51 (37%)
		TSP1	1479..1536	CDD:214559	6/56 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810