DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and Thsd7b

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_038946352.1	Gene:	Thsd7b / 289007	RGDID:	1306938	Length:	1609	Species:	Rattus norvegicus

Alignment Length:	1442	Identity:	291/1442 - (20%)
Similarity:	449/1442 - (31%)	Gaps:	525/1442 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DGNSCSQPLFNWEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRP---EASVEQC 306
            :|...:|  |.|:..|..:|:..||.|...||.:....:.........|..::||   .:....|
  Rat    35 EGRKDNQ--FIWKTGPWGRCAGDCGPGGTQSRAVWCFHIEGWTSPMANCDESSRPPKERSCFRVC 97

  Fly   307 NTHSCPPRWIADDWSTCSRLCG----------------HGYRERMVVCAEESNGIKTRVADIMCR 355
            :.||...:|...||..|..:.|                ||.:.|.|.|.::.|  :|.||..:|.
  Rat    98 DWHSDLFQWEVSDWHRCLLVPGAQGEPRPRAVECVTAQHGLQHRTVRCLQKLN--RTMVASEICE 160

  Fly   356 --TPKPPTQETCII---EECPHWEVEDWTGCSVSCGQGIQMR-----------GVECKSTDGSLS 404
              .|:|||::.|:|   .:|...|...|:.|...||:.:|.|           |::|.:...|.:
  Rat   161 HFVPQPPTEQACLIPCPRDCVVSEFSPWSTCPEGCGKKLQHRTRVAIAPPLYGGLQCPNLTESRA 225

  Fly   405 AKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGD 469
            .:. |::.|...::.|..:       |||    ..|...|....|.:|.              |.
  Rat   226 CEA-PISCPLGKEEYSFSL-------KVG----PWSKCRLPHLKEAELG--------------GR 264

  Fly   470 DVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEG 534
            :|.|..|    |..|.::...|.....|.:|....:......:.....:...|...:....:|..
  Rat   265 NVQDFSS----DSNEQVTLTHQSYKAQHHSQPGAIEIGFQTRQVWCTRSDGRNALLSLCMRDSFP 325

  Fly   535 PSLDPTYI-KDNE------WSPCSVTC-----GEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKK 587
            .::.|..: ||.|      |||||.||     ..|:|.|:.|.|       .:|......|....
  Rat   326 LTVQPCVMPKDCETSEWSPWSPCSKTCRSGTLSPGVRSRSRNVK-------HIAIGGGQECPELL 383

  Fly   588 PHDEVERCVED-----PCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSAS------- 640
               |.|.|:.:     ||           ||             |.||...:..|..|
  Rat   384 ---EKETCIAEGEFLQPC-----------PR-------------YSWRTSEWKECQVSLLLEQQD 421

  Fly   641 ---------CLGGVEELIINCVR----------EDNGRVVSPFLC-------------------- 666
                     |.||::...:.|.:          ::..|.|...||
  Rat   422 PLWHKTGPICGGGIQTREVYCAQSFPATITSRTKEVSRPVESTLCLGPAPSASQLCNVPCSTDCI 486

  Fly   667 ----------------SPETKPEARVR----------------------TCNDRPCPPRWNYSD- 692
                            .|:.|...|:|                      .|.|..| .||..|:
  Rat   487 VSSWSAWGPCVYENCHDPQGKKGFRMRQRHVLMESTGPVGHCPHLAESVPCEDPMC-YRWLASEG 550

  Fly   693 -YTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNV---LDCPVR---- 749
             ..|....||:|.:..:..|.:|  ||.:    |...:||.|||.:|..|.:   :||.|.
  Rat   551 ICIPDHGKCGLGHRILKAVCQNE--RGEE----VSGGLCPVPPPPERMACEIPCRMDCVVSEWTV 609

  Fly   750 -------------------------------------------------------WEVGEWSKCS 759
                                                                   ||...|..||
  Rat   610 WSSCSQSCSNKNSDGKQTRSRSIVALAGEGGKPCPGSQELQEYRLCNDHSCAQLYWETSAWGSCS 674

  Fly   760 H-----------------TCGYGFKDRKVEC-----KQIMAQE-HKIERPESMCPSAKPADKKPC 801
            .                 |||.|.:.|||.|     .|:|.:. .:..|||::.|...|. ||.|
  Rat   675 ENTLVTALNMSIGWNGEATCGVGIQTRKVFCIKSHVGQVMTKRCPESTRPETVRPCFLPC-KKDC 738

  Fly   802 NV------KPCP-PEDPKPVIQINNSTHIQHDPKKTKITLKVGGAG------LVFFGTQVK--IK 851
            .|      :||| |..|      .|:|..|   .:.:|.::....|      .:|...:.:  ..
  Rat   739 LVTAFSEWRPCPWPCQP------GNTTIKQ---SRYRIIIQEAANGGQECPDTLFEERECEDISL 794

  Fly   852 CPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISIEVKAK 916
            ||..|:...  |||......:..|:.:.....|               |..||.:.::|.
  Rat   795 CPTYRWKPQ--KWSPCILVPESIRQGRTGTSEA---------------CGKGLQTRDVSC----- 837

  Fly   917 PGQQIEELEQQETERLVREKSGTEALTSADMKSADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQS 981
               ..::.:..|....:|:.:|...|......:.....|.|.....:..:.:.:....||||
  Rat   838 ---ISDDNQSAEMTECLRQMNGMPPLVQECTIACREDCTFTPWSKFTPCSKNCEATQIRRRQ--- 896

  Fly   982 ERLQNGRERSRRPKSDGVQHADSSIMEDDLSQLVQSEDRIPQPASASSGGSRTRTLLAMPYFQAL 1046
               ..|:.|.:....|.           .|..||:.|   |.|..|         .::.||..
  Rat   897 ---LTGKSRKKERCQDA-----------SLYPLVELE---PCPCDA---------FMSHPYGN-- 933

  Fly  1047 LSNLQLLW-----PLQRFKDSRGQHLLQGEALKFG----------IDLSGKDFDQDESERVPAEQ 1096
                   |     |..:....:|...:||:..:.|          .|::|:
  Rat   934 -------WSACILPEGKRDPQQGGLWVQGDDKECGEGVRFRAIACTDINGR-------------- 977

  Fly  1097 LPPEVLHSPSDPEYHEPSKSGPEADVPHVPPHMPHARWET-GAAASTTAVP-------------- 1146
                    |.||.:...|....||.|...|.....:.|.: |:.:|:..:.
  Rat   978 --------PVDPSFCNSSGYIQEACVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYS 1034

  Fly  1147 --------SLPNDGFV------------YRWMLGEWSQC-------SQECGAAGSGLQRRTVSCQ 1184
                    .|.|...|            |.|::..||.|       |..|   |.|.|.|.:.|.
  Rat  1035 GGRPCPKLDLKNQAQVHEAVPCYSECDQYSWVVEHWSPCKINNELRSPRC---GRGTQSRRIRCV 1096

  Fly  1185 RAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQSCGNEACP------QWSKGDWTPCQRSHC 1243
                     ||:|.|...||.|.|  :..:.|...|:| :..||      :|  |.|:.|.:| |
  Rat  1097 ---------STADREGGAVDRSLC--NQDDAPPETQAC-SLLCPSECVMSEW--GTWSKCPQS-C 1146

  Fly  1244 HGRNTAMQRREV--------TCRYPNGTEGSICDEYERPAMRQECYNERC-EGVWRVEPWSEC-- 1297
            ....|..:.|.:        ||    |.:..:     ||.:    .||.| :..:.:..||.|
  Rat  1147 DPHATQRRTRHLLRPSLNSRTC----GEDSQV-----RPCL----LNENCFQFQYNLTEWSTCQL 1198

  Fly  1298 --NAPCGRKGIKYRILQCVWYGSRRPAGNVCKHQ--PRPAVMKVCKSPAC--QAQLS-----SSP 1351
              |..|| :|::.|:|.||....:..:.:.|:.:  .:|..|.:.....|  ..|||     :..
  Rat  1199 SENISCG-QGVRTRLLSCVRSDGKPVSMDHCEERNLDKPQRMSIPCLVECVVNCQLSGWTTWTEC 1262

  Fly  1352 AQLCRDSSRYCR 1363
            :|.|....|..|
  Rat  1263 SQTCGQGGRMSR 1274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559
		TSP1	546..600	CDD:214559	18/69 (26%)
		TSP1	750..807	CDD:214559	25/85 (29%)
		IGc2	845..902	CDD:197706	9/58 (16%)
		PLAC	1355..1384	CDD:285849	3/9 (33%)
Thsd7b	XP_038946352.1	TSP1_ADAMTS	44..95	CDD:408800	11/50 (22%)
		TSP1_spondin	180..229	CDD:408798	11/49 (22%)
		TSP1_spondin	337..398	CDD:408798	18/70 (26%)
		TSP1_spondin	602..660	CDD:408798	2/57 (4%)
		TSP1_ADAMTS	665..734	CDD:408800	19/68 (28%)
		TSP1_spondin	738..789	CDD:408798	13/59 (22%)
		TSP1_ADAMTS	1065..1125	CDD:408800	22/74 (30%)
		TSP1_spondin	1131..1177	CDD:408798	12/57 (21%)
		TSP1_spondin	1251..1304	CDD:408798	7/24 (29%)
		TSP1_spondin	1374..1433	CDD:408798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900