DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and Adamts13

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_001001322.1	Gene:	Adamts13 / 279028	MGIID:	2685556	Length:	1426	Species:	Mus musculus

Alignment Length:	930	Identity:	224/930 - (24%)
Similarity:	318/930 - (34%)	Gaps:	326/930 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP------GSCRGESTRYRICNMQPCPEQQ-DFRSSQ 133
            |.||||...|.|||:|.||::.:.|.|.:|      .:|.||..:.::||.|.|.:.| :|.|.|
Mouse   390 GHWSSWGPHSPCSRSCGGGVITRRRWCNNPRPAFGGRACVGEDLQAKMCNTQACEKTQLEFMSEQ 454

  Fly   134 CSAYNDVPY---DGT--LYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQS 193
            |:..:..|.   .||  .|.|.....|.:...| ||    |:...:.                :|
Mouse   455 CAQTDRQPLQLSQGTASFYHWDAAVQYSQGDTL-CR----HMCWAVG----------------ES 498

  Fly   194 VIVQLSARVQDGTRC------RSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCS-- 250
            .||....|..|||||      ..|:|.:|:.|.|:..|||.::.|.|..|.|.|||||.::||
Mouse   499 FIVSRGDRFLDGTRCVPSGPQDDGTLSLCLLGSCRTFGCDGRMDSQKVWDACQVCGGDNSTCSSR 563

  Fly   251 ------------------------------QPLFN------------------------------ 255
                                          :|||.
Mouse   564 NGSFTAGRAREYVTFLIVTPNMTNAHIVNRRPLFTHLAVRIQGHYIVAGKTSISPNTTYPSLLED 628

  Fly   256 ----------------------------------------------------------------W 256
                                                                            |
Mouse   629 YRVEYRVTLTEDQLPHLEEIHIRGPVRDDIEIQVYRRYGGEYGDLTHPDITFSYFQLKQQAAWVW 693

  Fly   257 EMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWS 321
             .|....|||:||:|.:.....|:::..:..|.:..|..:.:|.|..|.|.:..|.|.|:|.|:|
Mouse   694 -TAKRGPCSVSCGAGLRWVTYSCQDQAQDKWVKNAQCQGSPQPPAWQEPCVSAPCSPYWVAGDFS 757

  Fly   322 TCSRLCGHGYRERMVVCAEESNGIKTRVADIMCR--TPKPPTQ-ETCIIEECP-HWEVEDWTGC- 381
            .||..||.|.|||.:.|.|..:|....:....||  ..:|..: |.|..:.|| .|||.|...|
Mouse   758 PCSVSCGGGLRERSLRCVETQDGFLKTLPPARCRAVAQQPAAEVENCNSQPCPTRWEVSDPGPCM 822

  Fly   382 SVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNE 446
            |.:|..|:..|.|.|.|..|      || .||.:...|.|                 ....::.|
Mouse   823 SSACEAGLDSRNVTCVSRAG------DP-EKPETAGPCRT-----------------DEMSAMLE 863

  Fly   447 RSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEP 511
            ...|.|.|                             .||...|..:        .|.:|||...
Mouse   864 PCSRSLCS-----------------------------PGLGQVDNTM--------SLGEEAPSPV 891

  Fly   512 RTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSP----CSVTCGEGIRRRTYNCKIFLEYS 572
                            |.|:       |....::.|:|    ||::||.|::...:.|.    .|
Mouse   892 ----------------GSDK-------PGAQAEHVWTPLVGLCSISCGRGLKELYFLCM----DS 929

  Fly   573 RTVATVNDSLCE-GKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTS 636
            .....|.:.||. ..||....|.|...||                      |.:   |..|....
Mouse   930 VLKMPVQEELCGLASKPPSRWEVCRARPC----------------------PAR---WETQVLAP 969

  Fly   637 CSASCLGGVEELIINCVREDNGRVVS-PF-LCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKS 699
            |..:|.||...|.:.||:.|.|..:| |. .|||..|| .....|:..|||.||......|||.|
Mouse   970 CPVTCGGGRVPLSVRCVQLDRGHPISVPHSKCSPVPKP-GSFEDCSPEPCPARWKVLSLGPCSAS 1033

  Fly   700 CGIGIKTREVQCIHEVTRGGDN--------TMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWS 756
            ||:|..|:.|.|: ::.:|.||        .:|.|.:..|         |.:.||..||.:..|:
Mouse  1034 CGLGTATQMVACM-QLDQGHDNEVNETFCKALVRPQASVP---------CLIADCAFRWHISAWT 1088

  Fly   757 KCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPS-AKPADKKPCNVKPCPPEDPKPVIQINNS 820
            :||.:||.|.:.|...|   :..:.::..|.:.|.. .||...:.|...||..::        .|
Mouse  1089 ECSVSCGDGIQRRHDTC---LGPQAQVPVPANFCQHLPKPMTVRGCWAGPCAGQE--------TS 1142

  Fly   821 THIQHD----PKKTKITLKV 836
            :.:.|.    |.:|:....|
Mouse  1143 SSLPHKEATLPSQTQAAATV 1162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	20/51 (39%)
		TSP1	546..600	CDD:214559	16/58 (28%)
		TSP1	750..807	CDD:214559	15/57 (26%)
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
Adamts13	NP_001001322.1	ZnMc_ADAMTS_like	82..286	CDD:239801
		TSP1	392..444	CDD:214559	20/51 (39%)
		Cysteine-rich	445..561		41/136 (30%)
		Cell attachment site. /evidence=ECO:0000255	503..505		0/1 (0%)
		Spacer	556..685		6/128 (5%)
		ADAM_spacer1	565..683	CDD:283607	3/117 (3%)
		TSP1	754..810	CDD:214559	18/55 (33%)
		TSP1	1082..>1113	CDD:214559	9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810