DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and Adamtsl3

DIOPT Version :10

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_001177303.1 Gene:Adamtsl3 / 269959 MGIID:3028499 Length:1706 Species:Mus musculus


Alignment Length:1785 Identity:414/1785 - (23%)
Similarity:619/1785 - (34%) Gaps:641/1785 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGSCRGESTRYRICNMQPCP-EQQDFRSSQCSAYND 139
            |.|.:|.|||.|||||.||..:.:|||.:..:|.|::.||:.|:...|| :.:|||:.|||||||
Mouse    88 GNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPADAEDFRAQQCSAYND 152

  Fly   140 VPYDGTLYKWTPHY-DYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLSARVQ 203
            |.|.|..|:|.|.| |...||||.|                        |...||::|:|:.:|.
Mouse   153 VQYQGHYYEWIPLYNDPAAPCALKC------------------------HARGQSLVVELAPKVL 193

  Fly   204 DGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC------------------- 249
            |||||.:.||||||.|.||.||||.::||..|.|.||||.|||::|                   
Mouse   194 DGTRCNADSLDMCISGICQIVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQTKMHLSPEKKEEN 258

  Fly   250 --SQPL------------------------------FN--------------------------- 255
              :.||                              ||                           
Mouse   259 VIAVPLGSRSVRITVKGPALIFIESKTLQGSRGEHSFNSPGVFTVENTTIEFQKGADRQTFKIAG 323

  Fly   256 -------------------------------WEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVD 289
                                           |.......|:||||.||:::...|.:......|.
Mouse   324 PLMADFIFKTRYTVAKGSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECMDIRLKRVVP 388

  Fly   290 DTLCSV---TNRPEASVEQCNTHSCP-----------------PRWIADDWSTCSRLCGHGYRER 334
            |..|..   ..:|:..:::|:...||                 |||..:.|:.||..||.|.:.|
Mouse   389 DHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRR 453

  Fly   335 MVVCAEESNGIK-TRVADIMCR-TPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVECK 397
            ..||.|||...: .:|.:..|. .|||...:.|.:.:||.|...:|:.|:|:||:|::.|.|.|.
Mouse   454 SFVCVEESMHAEILQVEEWKCMYAPKPTVMQACNLFDCPKWVAMEWSQCTVTCGRGLRYRVVLCI 518

  Fly   398 STDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNE 462
            :..|.....|:|..|....::|...|.|                                     
Mouse   519 NHRGQHVGGCNPQMKLHIKEECVIPIPC------------------------------------- 546

  Fly   463 DENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNR 527
                                            |..|.:|.:..:.|...:...|           
Mouse   547 --------------------------------YKPREKSPVEAKLPWLKQAQEL----------- 568

  Fly   528 GEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEV 592
              :|:...:.:|.:|.: .||.||.|||.||:.|...|::.|.:::|.|.:.:..|||.||..: 
Mouse   569 --EETRIATEEPKFIPE-PWSACSTTCGPGIQVREVRCRVLLTFTQTEAELPEEECEGPKPPTD- 629

  Fly   593 ERCVEDPCMLPSHGFDDQFPRDSIKVG----VSEPGKTYVWREQGYTSCSASCLGGVEELIINCV 653
            ..|:...|        ||.| .|.::|    ..:...||.|...|:|.|:|:||||.:|.|..|:
Mouse   630 RPCLRQAC--------DQSP-VSRELGGRLQEKDSEMTYDWEYAGFTPCTATCLGGHQEAIAVCL 685

  Fly   654 REDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRG 718
            .....:.|:..||....:|....:.||..||||||:...:..||.:||:||:||:|.|:|     
Mouse   686 HTQTHQTVNDSLCDTVHRPPPMSQACNMEPCPPRWHMGSWGACSATCGVGIQTRDVYCLH----- 745

  Fly   719 GDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKI 783
             ......|...|.:..|...:.||..|||..|.:.||.:||.|||.|.::|:|.|:|::.....:
Mouse   746 -PEEFPAPPEECREEKPHALRACNQFDCPPSWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFL 809

  Fly   784 ERPESMCPSAKPADKKPCNVKPCPPE--------------------------------------- 809
            ...:.:|...|.:..|.|....|||:                                       
Mouse   810 NLSDELCQGPKASSHKSCARTDCPPQLAAGDWSKCSVTCGVGFQRRKQVCQKLTAKGRRVSVAET 874

  Fly   810 -------------------------------DPKPVIQINNSTHIQHDPKKTKITLKVGGAGLVF 843
                                           :..|.|......:||...:| :|.|.||....:.
Mouse   875 LCRDLPGLPLVRPCQMPICSKAKLGTKTKLGERGPQILGVRRVYIQTREEK-RINLTVGSRAYLL 938

  Fly   844 FGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAE 908
            ..|.|.|||||:|:.::.|:|.||...|:.|::..::|.|:|:|..:...|.|||.|.||.:...
Mouse   939 LNTSVIIKCPVRRFQKSLIQWEKDGHCLKNSKQLGITKSGSLKIHSLAAPDIGVYRCIAGSAQET 1003

  Fly   909 ISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSADMKSADGTGTS----------------- 956
            :.:::.....:.|.....:|.   ||...|      .|...|:..|.:                 
Mouse  1004 VVLKLIGTDNRLIAHPSLREH---VRGHPG------VDHNEANSLGATWHKMRQMWNNKNDLYLH 1059

  Fly   957 -----------TAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSSIME-- 1008
                       ...||.....|:......:.:|.:: .::.|.......:.|.:....|.:||  
Mouse  1060 GGEMNKQPFLRALFGPCRTSEGNDNSWEFKNKQFEA-AMKQGAYSMDTAQFDELIRNMSQLMEMG 1123

  Fly  1009 ---DDL--------------------------------SQLVQSEDRIPQPASASSGGSRT---- 1034
               |||                                :||....:|:|:..:..:.|..|    
Mouse  1124 EASDDLASQMIYQLVAELAKAQPTPVQWRGIREEVAPEAQLRGKTERVPKNPTVKNSGKLTFKPK 1188

  Fly  1035 -----RTLLAMPY-----FQALLSN--------------LQLLWPLQR--FKDSRGQHLLQGEAL 1073
                 |.:|....     ..|.:.|              ..|:.|.:.  :..::...||| .::
Mouse  1189 GPVLMRQILPPSVSFNKTINARIGNTVYITKSTEIINILCSLITPSKEATYTWTKDGALLQ-PSV 1252

  Fly  1074 KFGIDLSGK----------------------DFDQDESERVPAEQLPPEVL---HSPSDPEYHEP 1113
            |..:|.:||                      ..|.:.|..:.||  .|.:|   .:.:.||::..
Mouse  1253 KIILDETGKMQIRNPTRKEQGIYECSVASHLGSDVESSLVLYAE--APVILSIERNVTKPEHNHL 1315

  Fly  1114 S-------KSGPEADVP-HVPPH---MPHARW-ETGAAAS------------------------- 1141
            |       ::..:|:|. |.|..   .|:..| :||.:.|                         
Mouse  1316 SVVVGGTVEAALQANVTIHCPVKGVPQPNVTWLKTGGSLSDNVSLLFNGSLLLQSASLENEGTYI 1380

  Fly  1142 ---TTAV----------------------------------------------PSLPNDGFVYRW 1157
               |.|:                                              .|||.:.|   |
Mouse  1381 CTATNALGKAVATSGLRLLERREPGGKAAFPKVQKTRVLQAPRSRINSNNLTGKSLPQEHF---W 1442

  Fly  1158 MLGEWSQCSQECGAAGSGLQR-RTVSCQRAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQS 1221
            ..|.|:.||..||..|..||| |.|        .:||..       |..:.|..|...|.. |||
Mouse  1443 EPGNWTHCSATCGPLGFRLQRPRCV--------MASGQE-------VSEALCGPHRKPLAG-FQS 1491

  Fly  1222 CGNEACP-QWSKGDWTPCQRS-------------------------------------------- 1241
            |....|| :|....|:.|..|                                            
Mouse  1492 CNIRDCPARWFTSMWSECSASCGEGFHSRQVTCKQTKANGTVQVVSPRACAPKDRPLGRKPCSIR 1556

  Fly  1242 ---------------HCHGRNTAMQRREVTCRYPNGTEGSICDEYERPAMRQECYNERCEGVWRV 1291
                           .|.|..|.||.....|.:  .:..|.|::..|||..:.|....||..|||
Mouse  1557 PCVQQAIDPGNQCPGRCMGHATRMQHHHTACSH--NSSSSDCEDGRRPAFGRNCTLGPCEACWRV 1619

  Fly  1292 EPWSECNAPCGRKGIKYRILQCVWYGSRRPAGNVCKHQPRPAVMKVCKSPACQAQLSSSPAQLCR 1356
            .||..|.|.||| |.:.|.:.|:..||.:...:....|.:||..:.|..|:|...        |.
Mouse  1620 GPWKPCTAVCGR-GFQSRKVDCIHTGSCKIVADRYCVQVKPAAWRHCLGPSCDRN--------CT 1675

  Fly  1357 DSSRYCRNARAMGLCRLHRYKLKCCGSCEQ 1386
            |::.||...:.:.||.|..|:.:||.||::
Mouse  1676 DTTHYCMFVKHLNLCSLAVYRQRCCQSCQE 1705

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 20/45 (44%)
TSP1_ADAMTS 256..311 CDD:465950 14/57 (25%)
TSP1_ADAMTS 315..370 CDD:465950 19/56 (34%)
TSP1_ADAMTS 373..420 CDD:465950 14/46 (30%)
TSP1 546..600 CDD:214559 20/53 (38%)
TSP1_ADAMTS 629..684 CDD:465950 18/54 (33%)
TSP1_ADAMTS 688..746 CDD:465950 17/57 (30%)
TSP1_ADAMTS 750..806 CDD:465950 17/55 (31%)
Ig 845..914 CDD:472250 25/68 (37%)
Ig strand B 848..852 CDD:409353 2/3 (67%)
Ig strand C 861..865 CDD:409353 1/3 (33%)
Ig strand E 883..887 CDD:409353 2/3 (67%)
Ig strand F 897..902 CDD:409353 3/4 (75%)
TSP1_ADAMTS 1157..1227 CDD:465950 23/70 (33%)
TSP1_ADAMTS 1289..1343 CDD:465950 20/53 (38%)
PLAC 1355..1384 CDD:462560 10/28 (36%)
Adamtsl3NP_001177303.1 TSP1 90..136 CDD:214559 20/45 (44%)
ADAMTS_CR_3 141..239 CDD:437068 58/121 (48%)
TSP1_ADAMTS 355..413 CDD:465950 14/57 (25%)
TSP1_ADAMTS 434..491 CDD:465950 19/56 (34%)
TSP1_ADAMTS 494..546 CDD:465950 16/51 (31%)
TSP1_ADAMTS 582..637 CDD:465950 20/56 (36%)
TSP1_ADAMTS 661..716 CDD:465950 18/54 (33%)
TSP1_ADAMTS 720..772 CDD:465950 17/57 (30%)
TSP1_ADAMTS 776..832 CDD:465950 17/55 (31%)
TSP1_ADAMTS 838..893 CDD:465950 0/54 (0%)
Ig <942..1006 CDD:472250 24/63 (38%)
Ig strand B 943..947 CDD:409353 2/3 (67%)
Ig strand C 956..960 CDD:409353 1/3 (33%)
Ig strand E 978..982 CDD:409353 2/3 (67%)
Ig strand F 992..997 CDD:409353 3/4 (75%)
Ig strand G 1001..1004 CDD:409353 0/2 (0%)
Ig 1224..1291 CDD:409353 10/67 (15%)
Ig strand B 1224..1228 CDD:409353 0/3 (0%)
Ig strand C 1238..1242 CDD:409353 0/3 (0%)
Ig strand E 1260..1264 CDD:409353 2/3 (67%)
Ig strand F 1274..1279 CDD:409353 0/4 (0%)
Ig strand G 1288..1291 CDD:409353 0/2 (0%)
Ig 1331..1394 CDD:409353 10/62 (16%)
Ig strand B 1331..1335 CDD:409353 1/3 (33%)
Ig strand C 1344..1348 CDD:409353 0/3 (0%)
Ig strand E 1364..1368 CDD:409353 0/3 (0%)
Ig strand F 1378..1383 CDD:409353 0/4 (0%)
TSP1_ADAMTS 1442..1497 CDD:465950 23/70 (33%)
TSP1_ADAMTS 1501..1558 CDD:465950 4/56 (7%)
TSP1_ADAMTS 1617..1670 CDD:465950 20/53 (38%)
PLAC 1674..1704 CDD:462560 11/29 (38%)

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