DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and Adamtsl3

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_001177303.1	Gene:	Adamtsl3 / 269959	MGIID:	3028499	Length:	1706	Species:	Mus musculus

Alignment Length:	1785	Identity:	414/1785 - (23%)
Similarity:	619/1785 - (34%)	Gaps:	641/1785 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGSCRGESTRYRICNMQPCP-EQQDFRSSQCSAYND 139
            |.|.:|.|||.|||||.||..:.:|||.:..:|.|::.||:.|:...|| :.:|||:.|||||||
Mouse    88 GNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPADAEDFRAQQCSAYND 152

  Fly   140 VPYDGTLYKWTPHY-DYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLSARVQ 203
            |.|.|..|:|.|.| |...||||.|                        |...||::|:|:.:|.
Mouse   153 VQYQGHYYEWIPLYNDPAAPCALKC------------------------HARGQSLVVELAPKVL 193

  Fly   204 DGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC------------------- 249
            |||||.:.||||||.|.||.||||.::||..|.|.||||.|||::|
Mouse   194 DGTRCNADSLDMCISGICQIVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQTKMHLSPEKKEEN 258

  Fly   250 --SQPL------------------------------FN--------------------------- 255
              :.||                              ||
Mouse   259 VIAVPLGSRSVRITVKGPALIFIESKTLQGSRGEHSFNSPGVFTVENTTIEFQKGADRQTFKIAG 323

  Fly   256 -------------------------------WEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVD 289
                                           |.......|:||||.||:::...|.:......|.
Mouse   324 PLMADFIFKTRYTVAKGSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECMDIRLKRVVP 388

  Fly   290 DTLCSV---TNRPEASVEQCNTHSCP-----------------PRWIADDWSTCSRLCGHGYRER 334
            |..|..   ..:|:..:::|:...||                 |||..:.|:.||..||.|.:.|
Mouse   389 DHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRR 453

  Fly   335 MVVCAEESNGIK-TRVADIMCR-TPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVECK 397
            ..||.|||...: .:|.:..|. .|||...:.|.:.:||.|...:|:.|:|:||:|::.|.|.|.
Mouse   454 SFVCVEESMHAEILQVEEWKCMYAPKPTVMQACNLFDCPKWVAMEWSQCTVTCGRGLRYRVVLCI 518

  Fly   398 STDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNE 462
            :..|.....|:|..|....::|...|.|
Mouse   519 NHRGQHVGGCNPQMKLHIKEECVIPIPC------------------------------------- 546

  Fly   463 DENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNR 527
                                            |..|.:|.:..:.|...:...|
Mouse   547 --------------------------------YKPREKSPVEAKLPWLKQAQEL----------- 568

  Fly   528 GEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEV 592
              :|:...:.:|.:|.: .||.||.|||.||:.|...|::.|.:::|.|.:.:..|||.||..:
Mouse   569 --EETRIATEEPKFIPE-PWSACSTTCGPGIQVREVRCRVLLTFTQTEAELPEEECEGPKPPTD- 629

  Fly   593 ERCVEDPCMLPSHGFDDQFPRDSIKVG----VSEPGKTYVWREQGYTSCSASCLGGVEELIINCV 653
            ..|:...|        ||.| .|.::|    ..:...||.|...|:|.|:|:||||.:|.|..|:
Mouse   630 RPCLRQAC--------DQSP-VSRELGGRLQEKDSEMTYDWEYAGFTPCTATCLGGHQEAIAVCL 685

  Fly   654 REDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRG 718
            .....:.|:..||....:|....:.||..||||||:...:..||.:||:||:||:|.|:|
Mouse   686 HTQTHQTVNDSLCDTVHRPPPMSQACNMEPCPPRWHMGSWGACSATCGVGIQTRDVYCLH----- 745

  Fly   719 GDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKI 783
             ......|...|.:..|...:.||..|||..|.:.||.:||.|||.|.::|:|.|:|::.....:
Mouse   746 -PEEFPAPPEECREEKPHALRACNQFDCPPSWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFL 809

  Fly   784 ERPESMCPSAKPADKKPCNVKPCPPE--------------------------------------- 809
            ...:.:|...|.:..|.|....|||:
Mouse   810 NLSDELCQGPKASSHKSCARTDCPPQLAAGDWSKCSVTCGVGFQRRKQVCQKLTAKGRRVSVAET 874

  Fly   810 -------------------------------DPKPVIQINNSTHIQHDPKKTKITLKVGGAGLVF 843
                                           :..|.|......:||...:| :|.|.||....:.
Mouse   875 LCRDLPGLPLVRPCQMPICSKAKLGTKTKLGERGPQILGVRRVYIQTREEK-RINLTVGSRAYLL 938

  Fly   844 FGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAE 908
            ..|.|.|||||:|:.::.|:|.||...|:.|::..::|.|:|:|..:...|.|||.|.||.:...
Mouse   939 LNTSVIIKCPVRRFQKSLIQWEKDGHCLKNSKQLGITKSGSLKIHSLAAPDIGVYRCIAGSAQET 1003

  Fly   909 ISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSADMKSADGTGTS----------------- 956
            :.:::.....:.|.....:|.   ||...|      .|...|:..|.:
Mouse  1004 VVLKLIGTDNRLIAHPSLREH---VRGHPG------VDHNEANSLGATWHKMRQMWNNKNDLYLH 1059

  Fly   957 -----------TAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSSIME-- 1008
                       ...||.....|:......:.:|.:: .::.|.......:.|.:....|.:||
Mouse  1060 GGEMNKQPFLRALFGPCRTSEGNDNSWEFKNKQFEA-AMKQGAYSMDTAQFDELIRNMSQLMEMG 1123

  Fly  1009 ---DDL--------------------------------SQLVQSEDRIPQPASASSGGSRT---- 1034
               |||                                :||....:|:|:..:..:.|..|
Mouse  1124 EASDDLASQMIYQLVAELAKAQPTPVQWRGIREEVAPEAQLRGKTERVPKNPTVKNSGKLTFKPK 1188

  Fly  1035 -----RTLLAMPY-----FQALLSN--------------LQLLWPLQR--FKDSRGQHLLQGEAL 1073
                 |.:|....     ..|.:.|              ..|:.|.:.  :..::...||| .::
Mouse  1189 GPVLMRQILPPSVSFNKTINARIGNTVYITKSTEIINILCSLITPSKEATYTWTKDGALLQ-PSV 1252

  Fly  1074 KFGIDLSGK----------------------DFDQDESERVPAEQLPPEVL---HSPSDPEYHEP 1113
            |..:|.:||                      ..|.:.|..:.||  .|.:|   .:.:.||::..
Mouse  1253 KIILDETGKMQIRNPTRKEQGIYECSVASHLGSDVESSLVLYAE--APVILSIERNVTKPEHNHL 1315

  Fly  1114 S-------KSGPEADVP-HVPPH---MPHARW-ETGAAAS------------------------- 1141
            |       ::..:|:|. |.|..   .|:..| :||.:.|
Mouse  1316 SVVVGGTVEAALQANVTIHCPVKGVPQPNVTWLKTGGSLSDNVSLLFNGSLLLQSASLENEGTYI 1380

  Fly  1142 ---TTAV----------------------------------------------PSLPNDGFVYRW 1157
               |.|:                                              .|||.:.|   |
Mouse  1381 CTATNALGKAVATSGLRLLERREPGGKAAFPKVQKTRVLQAPRSRINSNNLTGKSLPQEHF---W 1442

  Fly  1158 MLGEWSQCSQECGAAGSGLQR-RTVSCQRAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQS 1221
            ..|.|:.||..||..|..||| |.|        .:||..       |..:.|..|...|.. |||
Mouse  1443 EPGNWTHCSATCGPLGFRLQRPRCV--------MASGQE-------VSEALCGPHRKPLAG-FQS 1491

  Fly  1222 CGNEACP-QWSKGDWTPCQRS-------------------------------------------- 1241
            |....|| :|....|:.|..|
Mouse  1492 CNIRDCPARWFTSMWSECSASCGEGFHSRQVTCKQTKANGTVQVVSPRACAPKDRPLGRKPCSIR 1556

  Fly  1242 ---------------HCHGRNTAMQRREVTCRYPNGTEGSICDEYERPAMRQECYNERCEGVWRV 1291
                           .|.|..|.||.....|.:  .:..|.|::..|||..:.|....||..|||
Mouse  1557 PCVQQAIDPGNQCPGRCMGHATRMQHHHTACSH--NSSSSDCEDGRRPAFGRNCTLGPCEACWRV 1619

  Fly  1292 EPWSECNAPCGRKGIKYRILQCVWYGSRRPAGNVCKHQPRPAVMKVCKSPACQAQLSSSPAQLCR 1356
            .||..|.|.||| |.:.|.:.|:..||.:...:....|.:||..:.|..|:|...        |.
Mouse  1620 GPWKPCTAVCGR-GFQSRKVDCIHTGSCKIVADRYCVQVKPAAWRHCLGPSCDRN--------CT 1675

  Fly  1357 DSSRYCRNARAMGLCRLHRYKLKCCGSCEQ 1386
            |::.||...:.:.||.|..|:.:||.||::
Mouse  1676 DTTHYCMFVKHLNLCSLAVYRQRCCQSCQE 1705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	20/45 (44%)
		TSP1	546..600	CDD:214559	20/53 (38%)
		TSP1	750..807	CDD:214559	17/56 (30%)
		IGc2	845..902	CDD:197706	23/56 (41%)
		PLAC	1355..1384	CDD:285849	10/28 (36%)
Adamtsl3	NP_001177303.1	TSP1	90..136	CDD:214559	20/45 (44%)
		TSP1	438..492	CDD:214559	18/53 (34%)
		TSP1	498..>527	CDD:214559	10/28 (36%)
		TSP1	583..>603	CDD:214559	10/20 (50%)
		TSP1	720..773	CDD:214559	18/58 (31%)
		TSP1	776..833	CDD:214559	17/56 (30%)
		TSP1	839..894	CDD:214559	0/54 (0%)
		Ig	942..1006	CDD:299845	24/63 (38%)
		Ig	1234..1293	CDD:299845	9/59 (15%)
		IG_like	1321..1393	CDD:214653	11/71 (15%)
		IGc2	1330..1388	CDD:197706	10/57 (18%)
		TSP_1	1503..1558	CDD:301595	3/54 (6%)
		PLAC	1674..1704	CDD:285849	11/29 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11945
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1162
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D26058at33208
OrthoFinder	1	1.000	-	-		FOG0004452
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106353
Panther	1	1.100	-	-	LDO	PTHR13723
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7766
SonicParanoid	1	1.000	-	-		X3156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860