DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and Adamts12

DIOPT Version :9

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_780710.2 Gene:Adamts12 / 239337 MGIID:2146046 Length:1600 Species:Mus musculus


Alignment Length:1502 Identity:331/1502 - (22%)
Similarity:477/1502 - (31%) Gaps:598/1502 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 RSKVQSAGGGGGAG------GG------------PGQWSSWSDWSTCSRTCDGGIMHQMRRCGSP 105
            |||:.:|..|...|      .|            ||.|..||.||.|||||..|.....|.|.:|
Mouse   512 RSKLDAAADGTRCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGAQSAERLCNNP 576

  Fly   106 GS------CRGESTRYRICNMQPC-PEQQDFRSSQCSAYNDVPYDGTLYKWTPHYDYVEPCALTC 163
            ..      |.||..|||:||:.|| .:...||..|||.::.|||....|:|.|.::...||.|.|
Mouse   577 EPKFGGKYCTGERKRYRLCNVHPCRSDTPTFRQMQCSEFDTVPYKNQFYRWFPVFNAAHPCELYC 641

  Fly   164 RGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLSARVQDGTRCRSG--SLDMCIQGKCQRVGC 226
            |                       ..|||.....|.| |.|||.|..|  |.::||.|.|:||||
Mouse   642 R-----------------------PIDEQFSERMLEA-VIDGTPCFEGGNSRNVCINGICKRVGC 682

  Fly   227 DLKIGSTKKIDGCGVCGGDGNSCS--QPLFNWEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVD 289
            |.:|.|....|.||||.|||::|.  :.||..:.          ||||             .|:.
Mouse   683 DYEIDSNATEDRCGVCLGDGSACQTVKKLFRQKE----------GSGY-------------VDIG 724

  Fly   290 DTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMC 354
                                                |...|.|:                     
Mouse   725 ------------------------------------LIPKGARD--------------------- 732

  Fly   355 RTPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQC 419
                                                :|.:|.|:....|:.:.:...|    ...
Mouse   733 ------------------------------------IRVMEIKAAGNFLAIRSEDPEK----YYL 757

  Fly   420 STG--IHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDD 482
            :.|  |...|:. |:.||:.                          :.|...|::.|.:...|::
Mouse   758 NGGFIIQWNGNY-KLAGTVF--------------------------QYDRKGDLEKLIAPGPTNE 795

  Fly   483 GEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEW 547
            ...|.     ||:                                                    
Mouse   796 SVWLQ-----LLF---------------------------------------------------- 803

  Fly   548 SPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFP 612
               .|| ..||:           |..||.  .|.|      .::||:.:                
Mouse   804 ---QVT-NPGIK-----------YEYTVR--KDGL------DNDVEKLL---------------- 829

  Fly   613 RDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVR 677
                          |.|:...:|.||.:|..|:.....:||::.:|.|.:.| |:|||:|..|.:
Mouse   830 --------------YFWQFGRWTECSVTCGTGIRRQAAHCVKKGHGIVKTTF-CNPETQPSVRQK 879

  Fly   678 TCNDRPCPPRWNYSDYTPCSKSCG-IGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQY- 740
            .|:::.|||||...::..||.:|| .|.|.|.|.||.  |.|.|...:         |..|.|: 
Mouse   880 KCHEKDCPPRWWAGEWEACSTTCGPYGEKKRTVLCIQ--TMGSDEQAL---------PATDCQHL 933

  Fly   741 --------CN--VLDCPVRWEVGEWSKCSHTCGYGFKDRKVEC-KQIMAQEHKIERPES------ 788
                    ||  :| ||..|.||.||:||.:||.|.:.|.|.| |.:.....|..:|.|      
Mouse   934 LKPKALVSCNRDIL-CPSDWTVGNWSECSVSCGGGVRIRSVTCAKNLNEPCDKTRKPNSRALCGL 997

  Fly   789 -MCPSA----KP-------------ADKKPCNVKPCPPEDPKPVIQ------------------- 816
             .||.:    ||             |:..|....|.|...|.|:..                   
Mouse   998 QQCPFSRRVLKPNKDIAPSGKNQSTAEHDPFKPIPAPTSRPTPLSTPTVPESMSTSTPTINSLGS 1062

  Fly   817 -------------INNSTHIQ---HDPKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWS 865
                         .||||..:   |.|..:..|.:|                ||       ..||
Mouse  1063 TIASQEDANGMGWQNNSTQAEEGSHFPTSSGSTSQV----------------PV-------TSWS 1104

  Fly   866 KDHKPLQRSRKYKVSKKGALRILDI---TFRDAGVYSCHA---------GLSSAEISIEVKAKPG 918
            ...:|  .......|..|.....|.   |..|:|:.|..|         ...:.:..:|:.:..|
Mouse  1105 LSIQP--DDENVSSSAIGPTSEGDFWATTTSDSGLSSSDAMTWQVTPFYSTMTTDPEVEIHSGSG 1167

  Fly   919 QQIEE-LEQQETERLVREKSGT---EALTSADMKSADGTGTSTAVGPN-SHVNGSAQQHGSRRRQ 978
            :..:: |.:.::..::..|.|.   :|....|.:...|...::.:|.. |....|.:..||    
Mouse  1168 EDSDQPLNKDKSNSVIWNKIGVPEHDAPMETDAELPLGPPPTSYMGEEPSWPPFSTKMEGS---- 1228

  Fly   979 QQSERLQNGRERSRRPKSDGVQHADSSIMEDDLSQLVQSEDRIPQPAS-----ASSGGSRTRTLL 1038
                 |.....::..|:.||:              :.:...:||.|.:     |:|........|
Mouse  1229 -----LPAWSFKNETPRDDGM--------------IAEKSRKIPLPLAGDHHPATSEKLENHDKL 1274

  Fly  1039 AMPYFQALLSNLQLLWPLQRFKDSRGQHLLQGEA---LKFGIDLSGKDFDQDESERVPAEQLPPE 1100
            |:|.    .:|     |.|.|    |..|.:.:|   :..|..|:..|:.               
Mouse  1275 ALPN----TTN-----PTQGF----GPVLTEEDASNLIAEGFLLNASDYK--------------- 1311

  Fly  1101 VLHSPSDPEYHEPS-------------------------KSGPEADVPHV----PPHMPHARWET 1136
              |...|   |.|:                         .||.:||...:    |....|.|   
Mouse  1312 --HLMKD---HSPAYWIVGNWSKCSTTCGLGAYWRSVECSSGVDADCTTIQRPDPAKKCHLR--- 1368

  Fly  1137 GAAASTTAVPSLPNDGFVYRWMLGEWSQCSQECGAAGSGLQRRTVSCQRAAKATSSGSTSDTENN 1201
                        |..|    |.:|.||:||:.|   ..|.:.|.|.|.          .|...:.
Mouse  1369 ------------PCAG----WRVGNWSKCSRNC---SGGFKIREVQCM----------DSLDHHR 1404

  Fly  1202 VVDNSEC-FAHGLELPEFFQSCGNEACPQWSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNGTEG 1265
            .:....| |..|.. |....||..|.|.:|....|:.|.|| |.|   .:|.|.|:|      .|
Mouse  1405 SLRPFHCQFLAGAP-PPLSMSCNLEPCGEWQVEPWSQCSRS-CGG---GVQERGVSC------PG 1458

  Fly  1266 SICDEYERPAMRQECYNERCEGVWRVEPWSECNAPCGRKGIKYRILQCVWYGSRRPAGN------ 1324
            .:||..:|||....|....| ..|....|..||..|| .|.:.|.:.|:      |:.|      
Mouse  1459 GLCDWTKRPATTVPCNRHLC-CHWATGNWELCNTSCG-GGSQKRTIHCI------PSENSTTEDQ 1515

  Fly  1325 ---VCKHQPRPAVMKVCKSPACQAQLSSSPAQLCRD--SSRYCRNARAMGLCRLHRYKLKCCGSC 1384
               :|.||.:|...:.|...||:   .|:.....:|  |..:|:..::|..|.:...:.:||.||
Mouse  1516 DQCLCDHQVKPPEFQTCNQQACR---KSADLTCLKDRLSISFCQTLKSMRKCSVPSVRAQCCLSC 1577

  Fly  1385 EQQPNQH 1391
            .|.|:.|
Mouse  1578 PQAPSIH 1584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 24/52 (46%)
TSP1 546..600 CDD:214559 11/53 (21%)
TSP1 750..807 CDD:214559 24/81 (30%)
IGc2 845..902 CDD:197706 12/59 (20%)
PLAC 1355..1384 CDD:285849 7/30 (23%)
Adamts12NP_780710.2 Pep_M12B_propep 80..196 CDD:279848
Cysteine switch. /evidence=ECO:0000250 210..217
Reprolysin 250..460 CDD:279729
ZnMc_ADAMTS_like 250..457 CDD:239801
ADAM_CR 519..680 CDD:301627 61/184 (33%)
TSP1 549..600 CDD:214559 22/50 (44%)
Spacer 1 705..831 40/382 (10%)
ADAM_spacer1 706..816 CDD:283607 33/328 (10%)
TSP1 832..887 CDD:214559 18/55 (33%)
TSP1 950..1001 CDD:214559 17/50 (34%)
Spacer 2 1001..1321 69/400 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1006..1140 27/158 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1158..1179 3/20 (15%)
TSP1 1430..1478 CDD:214559 19/57 (33%)
TSP1 1480..1537 CDD:214559 16/63 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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