DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and Adamts20

DIOPT Version :9

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:XP_006520926.1 Gene:Adamts20 / 223838 MGIID:2660628 Length:1915 Species:Mus musculus


Alignment Length:1631 Identity:327/1631 - (20%)
Similarity:489/1631 - (29%) Gaps:662/1631 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSVNMNW-TSPKIWAAL-------FVTT---LCLLDTQAAWAKKLN---ASQAFDDT------WN 45
            |:..:|: |||..|:|.       |:.|   .||||........|:   ....:|..      :.
Mouse   436 MAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLLDKPNGRTYDLSPQLPGSVYDGNRQCELMFG 500

  Fly    46 TASDLENELEQQKRSKVQSAGG------------GGGAGGGP--------------------GQW 78
            ..|.:...|:..:|....||.|            ..|...||                    |:|
Mouse   501 PGSQVCPYLKHCRRLWCTSAEGVHKGCRTQHMPLADGTSCGPGMHCHRGLCVTRDMETRPVDGEW 565

  Fly    79 SSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPCPE-QQDFRSSQCSA 136
            ..|..:|:|||||.|||....|.|..|..      |.|...::|.||...||: ::|||..|||.
Mouse   566 GPWGPYSSCSRTCGGGIKSTARLCDRPEPRNGGRYCVGRRMKFRSCNTDSCPKGKRDFREKQCSD 630

  Fly   137 YNDVPYD----GTLYKWTPHYDYV---EPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSV 194
            ::...:|    ....:|.|.|..:   :.|.|.||         ::..|.               
Mouse   631 FDGKHFDINGLPPNVRWLPKYSGIAVKDRCKLYCR---------VAGTTS--------------- 671

  Fly   195 IVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC---------- 249
            ..||..||.|||.|.:.:.|:|:||.|::.|||..:.|..|.|.|||||||.:||          
Mouse   672 FYQLKDRVADGTPCGTETNDICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSCQTLAGVFNSA 736

  Fly   250 -------------------------SQP------------------------------------- 252
                                     .:|                                     
Mouse   737 HYGYNVVVKIPAGATNIEILQHSYSGRPEDDNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVF 801

  Fly   253 --------------------------------------------------LFNWE-MAPMSQCSV 266
                                                              ||:|: ..|...|:.
Mouse   802 EYSGSNNSIERINSTDRLEAELVLQVLCVGNLYNPDVRYSFNIPIEERSNLFSWDPYGPWQDCTK 866

  Fly   267 TCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGY 331
            .| .|....:..|..:..:|.|.|..|.....|....|:||. .|..||.....|.||..||.||
Mouse   867 MC-QGLHRRKIACVRKSDHAVVSDHNCGHLPMPLFVTEKCNM-DCELRWHIIGKSDCSSQCGQGY 929

  Fly   332 RERMVVCAEES--NGIKTRVADIMCRTP-KPPTQE----TCIIEECPHWEVEDWTGCSVSCGQGI 389
            |...|.|.:.|  .|....|.|..|... |||::|    :|::   ..|...:|:.||.|||.|.
Mouse   930 RTLDVHCMKYSVHKGQAVPVGDQYCGDQLKPPSREPCHGSCVL---TRWHYSEWSQCSRSCGGGD 991

  Fly   390 QMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDS 454
            :.|...|                                   |.|                    
Mouse   992 KTRESYC-----------------------------------VNG-------------------- 1001

  Fly   455 SDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNG 519
                                                    :.||.   ...|..:.||.: |.|.
Mouse  1002 ----------------------------------------FGHRL---AESECRELPRVV-LENC 1022

  Fly   520 NSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCE 584
            |            |.|.  |:: ..:|||.|.||||:|:::|...|::..:..|      |..|.
Mouse  1023 N------------EFPC--PSW-ATSEWSECPVTCGKGMKQRQVWCQLSEDPMR------DGFCN 1066

  Fly   585 GKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELI 649
            .....:.:..|....|.                          .|....:.||:|:|..|.:...
Mouse  1067 ASTKPESLRPCELRACA--------------------------SWHVGPWGSCTATCGHGYQMRA 1105

  Fly   650 INCVREDNGRVVSPFLCSPETKPEARVRTCNDRPC------------------PPRWNYSDYTPC 696
            :.|:.|..|.::....|...::|..| :.|...||                  ..:|.:..:|||
Mouse  1106 VKCISEIFGTMLDDRECPQASRPSDR-QDCILAPCLAIPEVGATSLPAIPLGRAAQWRHGSWTPC 1169

  Fly   697 SKSCGIGIKTREVQC--IHEVTRGGDNTMVVPN----SMCPQPPPADRQYCNVLDCPVRWEVGEW 755
            |.|||.|.:.|.|.|  .|:......|...:|.    |:|..|       |.      .|:.|:|
Mouse  1170 SVSCGRGSQARYVSCRDAHDEVADESNCAHLPRPAAVSLCFSP-------CG------EWQAGDW 1221

  Fly   756 SKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMC-PSAKPADKKPCNVKPCPP---------ED 810
            |.||.:||:|...|:|.|    ...|::. .||.| |..:|..::.|::..|||         |.
Mouse  1222 SPCSASCGHGKTTRRVLC----VNYHQLV-DESYCDPEGRPVTEQECSLAACPPLYSRAPSSSEQ 1281

  Fly   811 PKPVIQINNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSR 875
            |..|...|  ..:.|.|.:.:..           |.|:.|                      |..
Mouse  1282 PSHVPSRN--VPLTHKPGENQDQ-----------GAQLSI----------------------RGN 1311

  Fly   876 KYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTE 940
            :::....||..           .||..||                      |....:.:::.|..
Mouse  1312 QWRTGPWGACS-----------RSCAGGL----------------------QHRAVVCQDEDGRS 1343

  Fly   941 ALTSADMKSADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSS 1005
            | ||.|..|..........||..|.|     :|                                
Mouse  1344 A-TSCDGSSKPPESRHCGSGPCPHWN-----YG-------------------------------- 1370

  Fly  1006 IMEDDLSQLVQSEDRIPQPASASSGGSRTRTLLAMPYFQALLSNLQLLWPLQRFKDSRGQHLLQG 1070
                |..:..|:          ..||.::|.::.                               
Mouse  1371 ----DWGECTQT----------CGGGVKSRFVIC------------------------------- 1390

  Fly  1071 EALKFGIDLSGKDFDQDESERVPAEQLPPEVLHSPSDPEYHEPSKSGPEADVPHVPPHMPHARWE 1135
                                :.|..|:..|  ||...|:                ||.|....  
Mouse  1391 --------------------QFPNGQMTQE--HSCELPK----------------PPSMMQCH-- 1415

  Fly  1136 TGAAASTTAVPSLPNDGFVYRWMLGEWSQCSQECGAAGSGLQRRTVSCQRAAKATSSGSTSDTEN 1200
                     :.:.|.|   ..|..|.|..||..|   |.|::.|.|.|            .|...
Mouse  1416 ---------LHACPED---VSWYRGPWKSCSASC---GKGVKYREVLC------------IDQFQ 1453

  Fly  1201 NVVDNSECFAHGLELPEFFQSCGNEACPQWSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNGT-- 1263
            ..::...| :| |..|...::|.:..||.|....|..|..: |   .:.:|:|||.||. .||  
Mouse  1454 RKLEEKYC-SH-LHKPRTHKACRSGRCPSWKANKWKECSVT-C---GSGVQQREVYCRL-RGTGR 1511

  Fly  1264 -EGSICDEYERPAMRQECYNERC-EGVWRVEPWSECNAPCGRKGIKYRILQCVWYGSRRPAGNVC 1326
             ...:||...||..:::|:.:.| ...|....|.:|:..|.:|. .||:::||...:.:...::|
Mouse  1512 VSEDMCDPSTRPQGQRQCWRQDCMRYQWTTGDWLDCSTSCKKKE-TYRLVKCVNEQNVQANESLC 1575

  Fly  1327 KHQPRPAVMKVCKSPACQAQLSSSPAQLCRDSS--------RYCRNARAMGLCRLHRYKLKCCGS 1383
            ....:|..:|.|::|.|:..:.:..:..|..:.        .||...::......|:.:....|.
Mouse  1576 DPLTKPLSIKKCRNPHCKYSVVTGDSSQCAGNCGFTSPQKITYCTKIQSSKKHTFHQLRPVVYGE 1640

  Fly  1384 CEQQPN 1389
            |...|:
Mouse  1641 CPVIPS 1646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 19/51 (37%)
TSP1 546..600 CDD:214559 15/53 (28%)
TSP1 750..807 CDD:214559 19/57 (33%)
IGc2 845..902 CDD:197706 8/56 (14%)
PLAC 1355..1384 CDD:285849 5/36 (14%)
Adamts20XP_006520926.1 Pep_M12B_propep 50..195 CDD:366707
ZnMc_ADAMTS_like 264..470 CDD:239801 10/33 (30%)
ADAM_CR_2 485..552 CDD:375321 10/66 (15%)
TSP1 565..617 CDD:214559 19/51 (37%)
ADAM_spacer1 727..845 CDD:368694 1/117 (1%)
TSP1 975..1028 CDD:214559 22/165 (13%)
TSP1 1030..1082 CDD:214559 15/58 (26%)
TSP1 1085..1139 CDD:214559 13/54 (24%)
TSP1 1164..>1188 CDD:214559 11/23 (48%)
TSP1 1213..1269 CDD:214559 20/66 (30%)
TSP1 1313..1365 CDD:214559 15/85 (18%)
TSP1 1366..1420 CDD:214559 17/184 (9%)
TSP1 1428..1479 CDD:214559 16/67 (24%)
GON 1719..1914 CDD:370060
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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