DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and THSD7A

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_056019.1	Gene:	THSD7A / 221981	HGNCID:	22207	Length:	1657	Species:	Homo sapiens

Alignment Length:	1614	Identity:	304/1614 - (18%)
Similarity:	477/1614 - (29%)	Gaps:	602/1614 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 SSWSDWSTCSRTCDGGIMHQMRRCGSP----GSCRGESTRYRICNMQPCPEQQDFRS-------S 132
            |.:|.||.||:||..|:.|:.|...:|    ||.....|.:::|...|| |.::.|.       |
Human   198 SEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPC-EAEELRYSLHVGPWS 261

  Fly   133 QCSAYNDVPYDGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGD---------------GN 182
            .||              .||...|.....  ||......:|.|:...|               .|
Human   262 TCS--------------MPHSRQVRQARR--RGKNKEREKDRSKGVKDPEARELIKKKRNRNRQN 310

  Fly   183 AEEAEHYD-------EQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCG 240
            .:|.:::|       .:.:.:..:.:..|.:.|:...|.|..|      .|.:    ||:   |.
Human   311 RQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQ------SCVI----TKE---CQ 362

  Fly   241 VCGGDGNSCSQPLFNWEMAPMSQCSVTCGSGYKMSRPICRNRLTNADV------DDTLCSVTNRP 299
            |.              |.:..|.||.||   :.|..| ...|:....:      .:..|......
Human   363 VS--------------EWSEWSPCSKTC---HDMVSP-AGTRVRTRTIRQFPIGSEKECPEFEEK 409

  Fly   300 EASVEQ------CNTHSCPPRWIADDWSTC----------------SRLCGHGYRERMVVCAEES 342
            |..:.|      |.|:.    |...:|:.|                :.|||.|.:.|.|.|.:.:
Human   410 EPCLSQGDGVVPCATYG----WRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQAN 470

  Fly   343 NGIKTRVA-----------DI-MCRTPKPPTQETCIIEECP-HWEVEDWTG---CSVSCGQGIQM 391
            ..:.::::           |: :|..|.|.|.:.|.| .|| ..||..|:.   |:..
Human   471 ENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHI-PCPTECEVSPWSAWGPCTYE------- 527

  Fly   392 RGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSD 456
               .|....|....|   |.|.....:            ..||:.:.|:...|.|...
Human   528 ---NCNDQQGKKGFK---LRKRRITNE------------PTGGSGVTGNCPHLLEAIP------- 567

  Fly   457 ADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNS 521
                                            .::|..|..:. .||....||        ||..
Human   568 --------------------------------CEEPACYDWKA-VRLGNCEPD--------NGKE 591

  Fly   522 NNNFNRGED----ESEGPSLDPTYIKD----------------------NEWSPCSVTC------ 554
            .....:.::    .|:|..:|....:|                      :.||.||.||
Human   592 CGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTE 656

  Fly   555 GEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVG 619
            |:.||.|:     .|.|:.....:.   |.......||..|.|.||.: .|.....:.:......
Human   657 GKQIRARS-----ILAYAGEEGGIR---CPNSSALQEVRSCNEHPCTV-YHWQTGPWGQCIEDTS 712

  Fly   620 VSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPC 684
            ||....|..|..:      |||..|::...:.|||.:.|: |.|..|....:||. ||.|. .||
Human   713 VSSFNTTTTWNGE------ASCSVGMQTRKVICVRVNVGQ-VGPKKCPESLRPET-VRPCL-LPC 768

  Fly   685 ------PPRWNYSDYTPCSKSCGIGIKTREVQCIHEV-----TRGG-DNTMVVPNSMCPQPPPAD 737
                  .|   |||:|.|..||..|..:...|..|.|     ..|| |.|..:......:.|.|.
Human   769 KKDCIVTP---YSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQAC 830

  Fly   738 RQYCNVLDCPVRWEVGEWSKC--------------SHTCGYGFKDRKVECKQI---MAQEHKIER 785
            :.|        ||:..:|.:|              ...||.|.:.|.:.|::.   .|..|:..:
Human   831 QSY--------RWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQ 887

  Fly   786 PESMCPSAKPADKKPCNVKPCPPEDPKPVIQINNSTHIQHDPKKT-----KITLKVGGAGLV-FF 844
            .....|:...|.:.||. ..|...........|.........|:|     |...|...:.|. ..
Human   888 YAGPVPALTQACQIPCQ-DDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLI 951

  Fly   845 GTQVKIKCPVKRYNRTKI-KWSK------------------DHKPLQRSRKYKV----SKKGALR 886
            .||.   ||..:||...: .||.                  |.|...:..:|:.    .:.|  |
Human   952 ETQY---CPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNG--R 1011

  Fly   887 ILDIT-------FRDAGVYSCHAGLSSAEIS------------IEVKAK-----------PGQQI 921
            :::.:       ..:|.:..|.:....:|.|            ::|::|           |..::
Human  1012 LVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKL 1076

  Fly   922 EELEQQETERLVREKSG-------TE-----ALTSADMKSADGTGT---------STAVGPNSHV 965
            :.:.|.:...:|...|.       ||     .:|..:|:...|.|.         :||.||:.||
Human  1077 DHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHV 1141

  Fly   966 -----NGSAQQHGSRRRQ----------------------QQSERLQNGRERSRRPKSDG----- 998
                 :......|||..:                      .||...|...:..|:|..:|
Human  1142 EDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPN 1206

  Fly   999 ------------VQHADSSIMEDDLSQLVQSEDRIPQPASASSGGSRTRTLLAMPYFQALLSNLQ 1051
                        ..|.|.::.:....||.:.        :....|.:||.|..
Human  1207 AVEKEPCNLNKNCYHYDYNVTDWSTCQLSEK--------AVCGNGIKTRMLDC------------ 1251

  Fly  1052 LLWPLQRFKDSRGQHLLQGEALKFGIDLSGKDFDQDESERVPAEQLPPEVLHSPSDPEYHEPSKS 1116
                                     :...||..|....|.:..|:
Human  1252 -------------------------VRSDGKSVDLKYCEALGLEK-------------------- 1271

  Fly  1117 GPEADVPHVPPHMPHARWETGAAASTTAVPSLPNDGFVYRWMLGEWSQCSQECGAAGSGLQRRTV 1181
                            .|:    .:|:.:...|.:..:..|  ..||:|||.||..|..::||||
Human  1272 ----------------NWQ----MNTSCMVECPVNCQLSDW--SPWSECSQTCGLTGKMIRRRTV 1314

  Fly  1182 SCQRAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQSCGNEACPQWSKGDWTPC--QRSHCH 1244
                            |:....|...|    ..|.:..:.|..:.|.:|..|.|:||  |.:.|
Human  1315 ----------------TQPFQGDGRPC----PSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQC- 1358

  Fly  1245 GRNTAMQRREVTCRYPNGT--------EGSICDEYE------RPAMRQECYNERCEGVWRVEPWS 1295
            |..|  :.|.::|...:|:        :...|.:.|      :..:.:|..::.|.|...::.||
Human  1359 GEGT--RTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWS 1421

  Fly  1296 E---CNAPC------GRKGI----------------------------------KYRILQCVWYG 1317
            .   |...|      |..||                                  :|:.:...|.|
Human  1422 SWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKG 1486

  Fly  1318 SRRPAG-------NV---CKHQPRPAVMKVCKSPACQAQLSSSPAQLCRDSSRY 1361
            |.|...       ||   |....:|...:.|..|..|.....|..:.|.....|
Human  1487 SSRTVWCQRSDGINVTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGY 1540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	17/48 (35%)
		TSP1	546..600	CDD:214559	17/59 (29%)
		TSP1	750..807	CDD:214559	14/73 (19%)
		IGc2	845..902	CDD:197706	15/86 (17%)
		PLAC	1355..1384	CDD:285849	2/7 (29%)
THSD7A	NP_056019.1	TSP1	197..247	CDD:214559	18/49 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..311		8/47 (17%)
		TSP_1	364..412	CDD:301595	11/65 (17%)
		TSP1	1039..>1077	CDD:214559	5/37 (14%)
		TSP1	1290..1340	CDD:214559	18/71 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1570..1591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810