DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and Adamts2

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_783574.1	Gene:	Adamts2 / 216725	MGIID:	1347356	Length:	1213	Species:	Mus musculus

Alignment Length:	976	Identity:	199/976 - (20%)
Similarity:	306/976 - (31%)	Gaps:	385/976 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP------GSCRGESTRYRICNMQPCPEQ-QDFRSSQ 133
            |.|.:|:.:.:|||||..|:..:.|:|.:|      .:|.|.:..:::||.|.||.. .|||..|
Mouse   563 GNWGAWTPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCNPQDCPNSLADFREEQ 627

  Fly   134 CSAYNDVPYD--GTLYKWTP--HYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSV 194
            |..: |:.::  ...:.|.|  |.|..|.|.|.|.          |:|||:
Mouse   628 CQQW-DLYFEHGDVQHHWLPHEHRDAKERCHLYCE----------SKETGE-------------- 667

  Fly   195 IVQLSARVQDGTRCR-SGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFNWEM 258
            :|.:...|.|||||. ..:..:|::|.|::||||..|||.|:.|.|||||||...|......:..
Mouse   668 VVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSRKQEDKCGVCGGDNTHCKVVKGTFTR 732

  Fly   259 APMSQCSVTCGSGYKMSR-PICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWST 322
            :|..|..:      ||.. |.....|...:.|      |.....||:...|..
Mouse   733 SPRKQDYI------KMFEIPAGARHLLIQEAD------TTSHHLSVKNLETGK------------ 773

  Fly   323 CSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCI---IEECPHWEV--EDWTGCS 382
                         .:..||::              ..|...:.|   :|    ||.  ||..
Mouse   774 -------------FILNEENH--------------LDPNSRSFIAMGVE----WEYRNEDER--- 804

  Fly   383 VSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIV-----GSSR 442
                        |...|.|.|.                             |||.|     |.:|
Mouse   805 ------------ETLQTIGPLH-----------------------------GTITVLVIPEGDTR 828

  Fly   443 -SLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQE 506
             ||..:.....||.:.|::|..|:|                             |.|.:..|
Mouse   829 ISLTYKYMIHEDSLNVDDNNVLEDD-----------------------------AVRHEWAL--- 861

  Fly   507 APDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEY 571
                                                  .:|||||..||.|.:...|.|:
Mouse   862 --------------------------------------KKWSPCSKPCGGGSQFTKYGCR----- 883

  Fly   572 SRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTS 636

Mouse   884 ----------------------------------------------------------------- 883

  Fly   637 CSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPC-PPRWNYSDYTPCSKSC 700
                             |..:.::|....||...||:|..|.||.:.| .|.|...::.||::||
Mouse   884 -----------------RRLDSKMVHRAFCSALAKPKAIRRACNPQECSQPVWVTGEWEPCTQSC 931

  Fly   701 G-IGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGY 764
            | .|::.|.|:||..:  ..:.|..|....|....|..|:.||...||.||..|.||:||.|||.
Mouse   932 GRTGMQVRSVRCIQPL--HNNTTRSVHTKHCNDHRPESRRACNRELCPGRWRAGSWSQCSVTCGN 994

  Fly   765 GFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCP------------------PEDP 811
            |.::|.|.|:  .|.::     ..:|...:|...:.|.:.|||                  |:..
Mouse   995 GTQERPVLCR--TADDN-----FGVCREERPETARICRLAPCPRNGSDPSKKSYVVQWLSRPDPD 1052

  Fly   812 KPVIQINNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIK-CPVKRYNRTKIKWSKDHKPLQRSR 875
            .|:.:|::....|.|..             :|...:|..: |.:..||:...|.....:.|..
Mouse  1053 SPIQKISSKDQCQGDKS-------------MFCRMEVLSRYCSIPSYNKLCCKSCNPPRNLSN-- 1102

  Fly   876 KYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTE 940
                ::.|.:........|..|:.  ..|....::.:|:..||..:|                 .
Mouse  1103 ----TEDGGVEPPPGKHNDIDVFM--PTLPGPTVATQVQPSPGPPLE-----------------A 1144

  Fly   941 ALTSADMKSADGTGTSTAVGPNSHVNGSAQQHGS------------RRRQQQSERLQNGRERSRR 993
            .|..:...:.:....:.||.....::|..::..|            :.|.|:.:.|.|..:|..:
Mouse  1145 PLNVSSTNATEDHPETNAVDVPYKIHGVDEEVPSPNLIPRRPSLYVKTRNQRIQELINAVQRKEK 1209

  Fly   994 P 994
            |
Mouse  1210 P 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	16/51 (31%)
		TSP1	546..600	CDD:214559	10/53 (19%)
		TSP1	750..807	CDD:214559	18/56 (32%)
		IGc2	845..902	CDD:197706	9/57 (16%)
		PLAC	1355..1384	CDD:285849
Adamts2	NP_783574.1	Pep_M12B_propep	99..210	CDD:279848
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..232
		ZnMc_ADAMTS_like	267..468	CDD:239801
		Reprolysin	269..471	CDD:279729
		TSP1	565..617	CDD:214559	16/51 (31%)
		Cell attachment site. /evidence=ECO:0000255	692..694		0/1 (0%)
		Spacer	723..851		37/226 (16%)
		ADAM_spacer1	724..838	CDD:283607	32/212 (15%)
		TSP1	864..915	CDD:214559	20/137 (15%)
		TSP1	918..977	CDD:214559	18/60 (30%)
		TSP1	983..1030	CDD:214559	17/53 (32%)
		PLAC	1064..1094	CDD:285849	8/42 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900