DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and Adamts18

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_006530858.1	Gene:	Adamts18 / 208936	MGIID:	2442600	Length:	1253	Species:	Mus musculus

Alignment Length:	936	Identity:	205/936 - (21%)
Similarity:	281/936 - (30%)	Gaps:	447/936 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GGAGGGP--GQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPCPE 125
            |..|..|  ||||:||.||.|||||.||:..|.|.|.:|..      |.|.|..|::||:.||||
Mouse   615 GELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCSNPKPQYGGKYCPGSSRIYKLCNINPCPE 679

  Fly   126 QQ-DFRSSQCSAYNDVPYDGTLYKWTPHYDYVEP---CALTCRGHPAHLVEDISRETGDGNAEEA 186
            .. |||:.||:.||:.|:.|.||:|.| |..||.   |.|.|:                     |
Mouse   680 NSLDFRAQQCAEYNNKPFRGWLYRWKP-YTKVEEEDRCKLYCK---------------------A 722

  Fly   187 EHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCS- 250
            |:::   ....:|.:|:|||.|.....|:||.|.|:.||||.::||....|.||||.||.::|.
Mouse   723 ENFE---FFFAMSGKVKDGTPCSPHRNDVCIDGICELVGCDHELGSKAVSDACGVCKGDNSTCKF 784

  Fly   251 ----------------------------------------------------------------- 250

Mouse   785 YKGLYLSQHKANEYYPVVTIPAGARSIEIQELQLSSSYLAVRSLSQKYYLTGGWSIDWPGDFTFA 849

  Fly   251 ------QPLFN-----------------------------WEMA--------------------- 259
                  |..||                             |:.|
Mouse   850 GTTFEYQRSFNRPERLYAPGPTNETLVFEILTQGKNPGIAWKYALPKVMNVTQPATKRYHHTWRT 914

  Fly   260 PMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCS 324
            ..|.||||||.||...:.||. |..:..|:.:.|||..:|....:.||..|||..|:..:||.||
Mouse   915 VQSDCSVTCGGGYISIKAICL-RDQHTQVNSSFCSVRTKPATEPKICNAFSCPAYWLPGEWSACS 978

  Fly   325 RLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGI 389
            :.|..|.:.|.:.|.::                ||..:|..:
Mouse   979 KSCAGGQQSRKIRCVQK----------------KPFQKEEAV----------------------- 1004

  Fly   390 QMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDS 454
                         |.:.| |::.|..:|.|:
Mouse  1005 -------------LHSLC-PVSTPTQVQVCN---------------------------------- 1021

  Fly   455 SDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNG 519
                                            |:|..|
Mouse  1022 --------------------------------SHACPP--------------------------- 1027

  Fly   520 NSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCE 584
                      :.|..|           ||.||.|||.|:|||...||     |....|:.:|||.
Mouse  1028 ----------EWSPSP-----------WSQCSKTCGRGVRRREVLCK-----SPAAETLPESLCS 1066

  Fly   585 GKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELI 649
            .....:..|.||...|           |:
Mouse  1067 SSPRPEAQEGCVLGRC-----------PK------------------------------------ 1084

  Fly   650 INCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHE 714
                   |.|:                          :|..|.::.||.:||:|::.||::|:.:
Mouse  1085 -------NNRL--------------------------QWIASAWSECSATCGLGVRKRELKCVEK 1116

  Fly   715 VTRGGDNTMVVPNSMC---PQPPPADRQYCNVLDCPV------RWEVGEWSKCSHTCGYGFKDRK 770
            ..:|  ..:..|...|   .:|.....:.||...|||      .|....|.:|:.|||.|.:.|.
Mouse  1117 TLQG--KLITFPERRCRNIKKPSLELEEACNQRTCPVYSMAVASWYSSPWQQCTVTCGGGVQTRS 1179

  Fly   771 VECKQIMAQEHKIERPESMC-PSAKPADKKPCNVKPCP-PE--DPKPVIQINNSTHI--QHDPKK 829
            |.|.|       ..||.|.| ...||...:.||...|| ||  |....:...:..|:  ||
Mouse  1180 VHCMQ-------QGRPSSSCLLHQKPPVLRACNTNFCPAPEKKDDPSCVDFFSWCHLVPQH---- 1233

  Fly   830 TKITLKVGGAGLVFFGTQVKIKCPVK 855
                   |.....|:|.|....|..|
Mouse  1234 -------GVCNHKFYGKQCCRSCTRK 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	24/51 (47%)
		TSP1	546..600	CDD:214559	21/53 (40%)
		TSP1	750..807	CDD:214559	19/57 (33%)
		IGc2	845..902	CDD:197706	4/11 (36%)
		PLAC	1355..1384	CDD:285849
Adamts18	XP_006530858.1	Pep_M12B_propep	99..237	CDD:366707
		ZnMc_ADAMTS_like	327..528	CDD:239801
		ADAM_CR_2	545..612	CDD:375321
		TSP1	626..678	CDD:214559	24/51 (47%)
		ADAM_spacer1	783..895	CDD:368694	5/111 (5%)
		TSP1	969..1026	CDD:214559	20/175 (11%)
		TSP1	1029..1083	CDD:214559	24/80 (30%)
		TSP1	1093..1150	CDD:214559	15/58 (26%)
		TSP1	1162..1210	CDD:214559	18/54 (33%)
		PLAC	1220..1250	CDD:370061	7/40 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810