Protein Alignment nolo and Thsd4

DIOPT Version :10

• Sequence 1: NP_001036374.1
• Gene: nolo / 35424
• FlyBaseID: FBgn0051619
• Length: 1394
• Species: Drosophila melanogaster
• Sequence 2: NP_001035516.2
• Gene: Thsd4 / 207596
• MGIID: 2672033
• Length: 1018
• Species: Mus musculus
• Alignment Length: 1125
• Identity: 206/1125 - (18%)
• Similarity: 295/1125 - (26%)
• Gaps: 610/1125 - (54%)

  Fly    73 GGPGQWSSWSDWSTCSRTCDGGIMHQMRRC----------------------------------- 102
            |.||.|.||..||.|||:|.||:|.|.|.|
Mouse    52 GSPGVWGSWGPWSACSRSCSGGVMEQTRPCLPSSYRARGGSRPNGRALSITGHVVSAVRTSVPLH 116

  Fly   103 -----------------------GS----------------------PG---------------- 106
                                   ||                      ||
Mouse   117 RSQEDQRALAGSNASRQGPAVVRGSRHPQARGREPSERRSRTRGPIGPGKYGYGKAPYILPLQTD 181

  Fly   107 ----------------------------------------------------------------- 106
                                                                             
Mouse   182 TTHTPQRLRRQRPSSRHSRSQEASASKQGYRPPTHQFSHSQPLYQSDSGPRSGLPPSEASIYQLP 246

  Fly   107 -------------------------------------------SCRGESTRYRICNMQPCPEQ-Q 127
                                                       ||.|...:|::||...|||. :
Mouse   247 LTHDQSYPAASSLFHRPELSSHHGARPHGAAQAFPQHLRSTAISCIGAYRQYKLCNTNACPESGR 311

  Fly   128 DFRSSQCSAYNDVPYDGTLYKWTPHYDYV--EPCALTCRGHPAHLVEDISRETGDGNAEEAEHYD 190
            ..|..||::||:.|:.|..|:|.|..:..  ..|.|.|:.            ||
Mouse   312 SIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQA------------TG----------- 353

  Fly   191 EQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC------ 249
             ....|:.:.:|.|||.|......:|:.|:|:.:|||..:||.|.:|.|||||||...|
Mouse   354 -YRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDFLGSDKVLDKCGVCGGDNTGCQVVSGV 417

  Fly   250 ----------------------------------------------------------------- 249
                                                                             
Mouse   418 FKHALTSLGYHRVVEIPQGATKINITEMHKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMF 482

  Fly   250 --------------------------------SQP------------------------------ 252
                                            .||
Mouse   483 TYKRPNEVSSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMRNNAISPQVPPHRRPGEPF 547

  Fly   253 --------------------------------LF------------------------------- 254
                                            :|
Mouse   548 NGQLEEEDRGQEDREEREKNQEKEDSQVEAPEVFTSESTQTFPVRHPERFPSHRPDNLVPPAPQP 612

  Fly   255 -------NWEMAPMSQCSVTCGSG--YKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHS 310
                   ||:....::||.|||.|  |.:.|  |.:|.|:.:|.::.|..:.:|....|.||...
Mouse   613 PRRSRDHNWKQLGTTECSTTCGKGSQYPIFR--CVHRNTHEEVPESYCDSSMKPTPEEEPCNLFP 675

  Fly   311 CPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCR-TPKPPTQETCIIEECPHWE 374
            ||..|...:||.||:.||.|.:.|.|:|.:........|....|: ..||.|..||.::.|..|:
Mouse   676 CPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQ 740

  Fly   375 VE-DWTGCSVSCGQGIQMRGVECKSTDGSL--SAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTI 436
            :. |||.|||.||.|.:.|.|:|.|..|.:  ..:|:...:|..::.|..| .|
Mouse   741 IRTDWTSCSVPCGVGQRTRDVKCVSNIGDMVHDEECNMKLRPNDIENCDMG-PC----------- 793

  Fly   437 IVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQS 501
              ..|..|.|.|||
Mouse   794 --AKSWFLTEWSER--------------------------------------------------- 805

  Fly   502 RLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCK 566
                                                            ||..||.|:|.|:..|
Mouse   806 ------------------------------------------------CSAECGAGVRTRSVVC- 821

  Fly   567 IFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWRE 631
                .:..|:::....|...:| .|...|...||                      .||. .|..
Mouse   822 ----MTNHVSSLPLEGCGNNRP-VEATPCDNGPC----------------------TGKV-EWFT 858

  Fly   632 QGYTSCSASCLGGVEELIINCVRE--DNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYT 694
            ..::.||..|..|.::..:.|||:  |...|:.|:.||...||.:: :.|:.:||..:|..::::
Mouse   859 GSWSQCSIECGSGTQQREVICVRKNADTFEVLDPYECSFLEKPPSQ-QACHLKPCGAKWFSTEWS 922

  Fly   695 PCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMC-PQPPPADRQYCNVLDC-PVRWEVGEWSK 757
            .|||||..|.:.|||:|:.:     |.|   |:|:| ||..|.:|:.||..|| |   ||.|
Mouse   923 MCSKSCQGGFRVREVRCLSD-----DMT---PSSLCDPQLKPEERESCNTQDCVP---EVDE--- 973

  Fly   758 CSHTCGYGFKDRKVECKQIM 777
               .|    ||:...|..::
Mouse   974 ---NC----KDKYYNCNVVV 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	25/249 (10%)
		TSP1_ADAMTS	256..311	CDD:465950	18/56 (32%)
		TSP1_ADAMTS	315..370	CDD:465950	18/55 (33%)
		TSP1_ADAMTS	373..420	CDD:465950	17/49 (35%)
		TSP1	546..600	CDD:214559	13/53 (25%)
		TSP1_ADAMTS	629..684	CDD:465950	16/56 (29%)
		TSP1_ADAMTS	688..746	CDD:465950	22/58 (38%)
		TSP1_ADAMTS	750..806	CDD:465950	7/28 (25%)
		Ig	845..914	CDD:472250
		Ig strand B	848..852	CDD:409353
		Ig strand C	861..865	CDD:409353
		Ig strand E	883..887	CDD:409353
		Ig strand F	897..902	CDD:409353
		TSP1_ADAMTS	1157..1227	CDD:465950
		TSP1_ADAMTS	1289..1343	CDD:465950
		PLAC	1355..1384	CDD:462560
Thsd4	NP_001035516.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..56		2/3 (67%)
		TSP1	57..>81	CDD:214559	14/23 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..240		4/123 (3%)
		ADAMTS_CR_3	317..411	CDD:437068	37/117 (32%)
		ADAMTS_spacer1	413..528	CDD:461796	2/114 (2%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	534..623		3/88 (3%)
		TSP1_ADAMTS	627..676	CDD:465950	17/50 (34%)
		TSP1_ADAMTS	680..736	CDD:465950	18/55 (33%)
		TSP1_ADAMTS	739..793	CDD:465950	19/54 (35%)
		TSP1_ADAMTS	797..850	CDD:465950	18/157 (11%)
		TSP1_ADAMTS	856..912	CDD:465950	16/56 (29%)
		TSP1_ADAMTS	916..967	CDD:465950	22/58 (38%)
		PLAC	975..1005	CDD:462560	4/16 (25%)