DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and T21B6.3

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_509829.2	Gene:	T21B6.3 / 181284	WormBaseID:	WBGene00011880	Length:	821	Species:	Caenorhabditis elegans

Alignment Length:	909	Identity:	182/909 - (20%)
Similarity:	259/909 - (28%)	Gaps:	381/909 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 NELEQQKRSKVQSAGGGGGAGGGPGQWSSWSDWSTC--------SRTCDGGIMHQMRRCGSPGSC 108
            ::::::||.:...|..|.|         .|:|||.|        |:.|:.|...|.|      .|
Worm   144 DKVDRKKRQQGDEAVEGVG---------DWTDWSHCSSNGHEVRSQACEYGRKIQRR------GC 193

  Fly   109 RGESTRYRICNMQPCP----------------EQQDFRSSQCSAYNDVPYDGTLYK--------- 148
            ...|...|:    |.|                :||..|..|........:...|.:
Worm   194 PARSAPQRV----PAPPAQQYAPRAPEYPSAQQQQQQREQQQREQQHREHQARLQQHQQQQQQQQ 254

  Fly   149 ----------------WTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQ 197
                            ..|.....:|.:.: ..|..||.....::......::.:...:|:...|
Worm   255 QQQQQRPPQPQPQPQPQPPQRPPQQPQSFS-GTHELHLQRQREQQQQQQQQQQQQQQRQQNPQQQ 318

  Fly   198 LSARVQDG---TRCRSG----------------------SLDMCIQGKCQRV-----GCDLKIGS 232
            .....|.|   .:.:||                      .||...|...||:     ..:.:..:
Worm   319 PQQTTQFGQSQIQLQSGPVPPQQHPQQQQPQQQPELERSPLDQHAQLYQQRMSQYRENFNQRHPA 383

  Fly   233 TKKIDGC--GVCGG----------------------------------------------DGNSC 249
            ..|.|.|  |.|..                                              ||..|
Worm   384 RPKADPCPGGFCAPVPQAPQQERPTPPPVLAPVINTATQPPLPQPYPTRYRPAPPPPPACDGQGC 448

  Fly   250 SQP------LFNWEMAPMSQCSVTCGSGYKMSRPIC-RNRLTNADVDDTLCSVTNRPEASVEQCN 307
            ..|      ..:|  :..|.||.|||.|.|..|..| .|....||.:             .|.||
Worm   449 VNPPVVSGVWHDW--SDWSTCSCTCGDGAKSRRRECSTNNCQGADYE-------------TEPCN 498

  Fly   308 THSCP--PRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEEC 370
            ...|.  ..|.  :|||||..||.|.|||...|...:|         .|. .|....|.|....|
Worm   499 LGPCQTWSEWC--EWSTCSASCGSGQRERTRFCHLGTN---------RCE-GKDYESEQCSAGPC 551

  Fly   371 PHW-EVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGG 434
            |.| :.|||..|||:||||:.:|...|                                   :||
Worm   552 PEWSQWEDWGQCSVTCGQGVAVRQRTC-----------------------------------LGG 581

  Fly   435 TIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRT 499
              :.|                                |.|..|..|:
Worm   582 --VFG--------------------------------DHLCQGPKTE------------------ 594

  Fly   500 QSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGP-SLDPTYIKDNEWSPCSVTCGEGIRRRTY 563
                 |.|.|                       .|| ||...:   .|||.||.:||.|::||..
Worm   595 -----QRACD-----------------------GGPCSLWSPW---QEWSTCSASCGSGMKRRQR 628

  Fly   564 NCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYV 628
            .|:...:            |:|  |::|.:.|...||                       .:...
Worm   629 VCQFGTD------------CQG--PNEESQFCYGPPC-----------------------AEWTE 656

  Fly   629 WREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSD- 692
            |.|  ::.||:.|..|.......|: ..||:..:  .|.   .|......|..:.|   .|:|:
Worm   657 WCE--WSGCSSKCGPGQRTRTRGCL-GPNGQEAT--TCQ---GPSIETTLCEGQSC---CNWSEW 710

  Fly   693 --YTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCP-QPPPADRQYCNVLDCPVR--WEV 752
              ::.|.|.||.|...|...|:        |:...|:|.|. ..|..:.:.||...|..:  |..
Worm   711 CHWSMCDKECGGGQSIRTRTCL--------NSAGSPDSSCHCDGPDREEKECNSQSCAPQCAWNT 767

  Fly   753 G-EWSKCSH--TCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADK-KPC-NVKPCPPEDP 811
            . |||.||.  .|..|.:.|..:|.           .||.|.....|:: :.| .:..|||:.|
Worm   768 WCEWSPCSTQLACEVGVQSRSRQCV-----------GESGCHCIGLAEESQQCRGLTQCPPKPP 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	14/53 (26%)
		TSP1	546..600	CDD:214559	16/53 (30%)
		TSP1	750..807	CDD:214559	15/61 (25%)
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
T21B6.3	NP_509829.2	PAN_AP	35..108	CDD:214680
		TSP1	458..502	CDD:214559	17/58 (29%)
		TSP1	505..552	CDD:214559	18/58 (31%)
		TSP1	554..604	CDD:214559	25/164 (15%)
		TSP1	606..651	CDD:214559	16/61 (26%)
		TSP1	654..704	CDD:214559	12/57 (21%)
		TSP1	707..759	CDD:214559	15/59 (25%)
		TSP1	765..809	CDD:214559	14/54 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810