Protein Alignment nolo and adt-3

DIOPT Version :10

• Sequence 1: NP_001036374.1
• Gene: nolo / 35424
• FlyBaseID: FBgn0051619
• Length: 1394
• Species: Drosophila melanogaster
• Sequence 2: NP_508681.3
• Gene: adt-3 / 180675
• WormBaseID: WBGene00020567
• Length: 940
• Species: Caenorhabditis elegans
• Alignment Length: 703
• Identity: 125/703 - (17%)
• Similarity: 184/703 - (26%)
• Gaps: 342/703 - (48%)

  Fly    76 GQWSSWSD--WSTCSRTCDG-------GIMHQMRRCGSPGS------CRGESTRYRICNMQPC-- 123
            |.||:|:|  ..||...|..       .||..:|:|.:|.|      |:|:..|..:|:...|
 Worm   513 GGWSTWNDRPAPTCGGRCSQCEIRGQIRIMRSIRQCNNPSSNNGGAPCQGDEARGMVCHRDVCNG 577

  Fly   124 PEQQDFRSSQCSAYND---VPY-----DGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGD 180
            ...:::.:..||...|   :|.     :|..::..       .|.:.|      |:      :|.
 Worm   578 DSIENYATRVCSRLRDENAIPNTILSGEGMQFEQA-------MCKIWC------LI------SGS 623

  Fly   181 GNAEEAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGD 245
            .|.....::             .||..|..|  ..||:|:|:.:.|    |||........|
 Worm   624 TNIRTVSNF-------------PDGAPCGPG--QYCIKGECRPLLC----GSTTLAYSEADC--- 666

  Fly   246 GNSCSQPLFNWEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEA--------- 301
                          |:|....|       :.|    .:.:....|.....||..:.
 Worm   667 --------------PLSVLQTT-------TTP----PMPHVHSVDQFAGKTNPYKEHKKTPFLNE 706

  Fly   302 ----SV-EQCNTHSCPPRWIADDWSTC-SRLCGHGYRERMVV---CAEESNGIKTRVADIMCR-- 355
                || .:|.|:.|..:.:......| :.:|....|||...   |......:.|.......|
 Worm   707 WSGWSVWSECVTYDCHTQGVKVRVRRCLAGVCAGALRERQPCTRPCTGSERPLTTSPPQQTFRNR 771

  Fly   356 --TPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMR------GVECKSTDGSLSAKCDPLTK 412
              .|.|..|...|:.:..||  ..|:.|||:||.|.::|      |.||..|.
 Worm   772 FIAPLPNRQTNMILRKVDHW--GPWSACSVTCGTGQKLRRRENCIGQECAETG------------ 822

  Fly   413 PGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESG 477
            |..||.|                                         .|::|
 Worm   823 PCVMQSC-----------------------------------------RENKN------------ 834

  Fly   478 QDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYI 542
                                                                          |:.
 Worm   835 --------------------------------------------------------------TWT 837

  Fly   543 KDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGF 607
            :.::||.|||.||||::.|...|  |..:           |.||  ..:|..|....|
 Worm   838 EWSQWSDCSVNCGEGVQFRKRAC--FAAF-----------CRGK--DSDVRNCYGQRC------- 880

  Fly   608 DDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKP 672
                         ||
 Worm   881 -------------SE-------------------------------------------------- 882

  Fly   673 EARVRTCNDRPCPPR---W-NYSDYTPCSKSCGIGIKTREVQCIHEVTRGGDN 721
                 |...||...|   | .:|.::.||..||||.:||..:|......|.||
 Worm   883 -----TTTRRPLVNRSGLWTGWSSWSSCSTKCGIGQRTRRRRCYQGSCLGDDN 930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	18/62 (29%)
		TSP1_ADAMTS	256..311	CDD:465950	11/68 (16%)
		TSP1_ADAMTS	315..370	CDD:465950	12/62 (19%)
		TSP1_ADAMTS	373..420	CDD:465950	16/52 (31%)
		TSP1	546..600	CDD:214559	17/53 (32%)
		TSP1_ADAMTS	629..684	CDD:465950	2/54 (4%)
		TSP1_ADAMTS	688..746	CDD:465950	14/35 (40%)
		TSP1_ADAMTS	750..806	CDD:465950
		Ig	845..914	CDD:472250
		Ig strand B	848..852	CDD:409353
		Ig strand C	861..865	CDD:409353
		Ig strand E	883..887	CDD:409353
		Ig strand F	897..902	CDD:409353
		TSP1_ADAMTS	1157..1227	CDD:465950
		TSP1_ADAMTS	1289..1343	CDD:465950
		PLAC	1355..1384	CDD:462560
adt-3	NP_508681.3	ZnMc_ADAMTS_like	201..416	CDD:239801
		ADAMTS_CR_2	434..502	CDD:465496
		TSP1	<699..751	CDD:472794	10/51 (20%)
		TSP1	791..829	CDD:214559	16/51 (31%)
		TSP1	836..881	CDD:214559	18/79 (23%)
		TSP1	896..940	CDD:214559	14/35 (40%)