DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and gon-1

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_001255448.1	Gene:	gon-1 / 177850	WormBaseID:	WBGene00001650	Length:	2165	Species:	Caenorhabditis elegans

Alignment Length:	1584	Identity:	350/1584 - (22%)
Similarity:	512/1584 - (32%)	Gaps:	550/1584 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGS---------------------CRGESTRYRICN 119
            |||..|..|..|||||.||:...:|.|.||.|                     |.|:..|||.||
Worm   589 GQWGDWRSWGECSRTCGGGVQKGLRDCDSPKSENEVETLKSNVTSRPRNGGKYCVGQRERYRSCN 653

  Fly   120 MQPCP-EQQDFRSSQCSAYN--DVPYDG---TLYKWTPHYDYVEP---CALTCR--GHPA-HLVE 172
            .|.|| :.|.:|..|||.:|  |:...|   |...|.|.|..|.|   |.|.||  |..| :|:.
Worm   654 TQECPWDTQPYREVQCSEFNNKDIGIQGVASTNTHWVPKYANVAPNERCKLYCRLSGSAAFYLLR 718

  Fly   173 DISRETGDGNAEEAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKID 237
            |                           :|.|||.|.....|:|:.|.|...|||.::.||.:.|
Worm   719 D---------------------------KVVDGTPCDRNGDDICVAGACMPAGCDHQLHSTLRRD 756

  Fly   238 GCGVCGGDGNSC----------------------------------------------------- 249
            .|||||||.:||
Worm   757 KCGVCGGDDSSCKVVKGTFNEQGTFGYNEVMKIPAGSANIDIRQKGYNNMKEDDNYLSLRAANGE 821

  Fly   250 ----------------------------------------------------------------- 249

Worm   822 FLLNGHFQVSLARQQIAFQDTVLEYSGSDAIIERINGTGPIRSDIYVHVLSVGSHPPDISYEYMT 886

  Fly   250 -----------SQPLFNWEMA-PMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEAS 302
                       |..|:.|.:. ..::|...| .|.:..:.:|.:..|:....|..|....:|:.:
Worm   887 AAVPNAVIRPISSALYLWRVTDTWTECDRAC-RGQQSQKLMCLDMSTHRQSHDRNCQNVLKPKQA 950

  Fly   303 VEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMC-RTPKPPTQETCI 366
            ...||. .|..|||.:|.|:||..||.|.:.:.|.|.:.....:|..::.:| |..||....:|.
Worm   951 TRMCNI-DCSTRWITEDVSSCSAKCGSGQKRQRVSCVKMEGDRQTPASEHLCDRNSKPSDIASCY 1014

  Fly   367 IEECP--HWEVEDWTGCSVSCGQGIQM-RGVEC-----KSTDGSLSAK---------CDPLTKP- 413
            | :|.  .|...:||.||.:||...:| |...|     :..|.||..:         |:.:..|
Worm  1015 I-DCSGRKWNYGEWTSCSETCGSNGKMHRKSYCVDDSNRRVDESLCGREQKEATERECNRIPCPR 1078

  Fly   414 ---GSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDAD---------EDNEDEND 466
               |...:||..  |.|.:..               |..:.||::|.:         :..|..|:
Worm  1079 WVYGHWSECSRS--CDGGVKM---------------RHAQCLDAADRETHTSRCGPAQTQEHCNE 1126

  Fly   467 EGDDVDDLESGQDTDD--GEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGE 529
            ............|...  |:|:.|.|......||:       ...|.|.:.:            |
Worm  1127 HACTWWQFGVWSDCSAKCGDGVQYRDANCTDRHRS-------VLPEHRCLKM------------E 1172

  Fly   530 DESEGP---SLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLC--EGKKPH 589
            .....|   ...|.| |..|||.|||:|.:|...|..:|     .|.....|:.|||  ...:|
Worm  1173 KIITKPCHRESCPKY-KLGEWSQCSVSCEDGWSSRRVSC-----VSGNGTEVDMSLCGTASDRP- 1230

  Fly   590 DEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCV- 653
                 .....|.|                     |....||...:::||.||..|..|....|:
Worm  1231 -----ASHQTCNL---------------------GTCPFWRNTDWSACSVSCGIGHRERTTECIY 1269

  Fly   654 REDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRG 718
            ||.:   |....|.....||.. :||:..|| ..|..|.::|||.:||.||:||.|.|    |||
Worm  1270 REQS---VDASFCGDTKMPETS-QTCHLLPC-TSWKPSHWSPCSVTCGSGIQTRSVSC----TRG 1325

  Fly   719 GDNTMVVPNSMCPQ-PPPADRQYCNVLDC--------------PVRWEVGEWSKCSHTCGYGFKD 768
            .:.| :|....|.: ..|..::.|....|              |:||..|.|:.||.|||.|.:.
Worm  1326 SEGT-IVDEYFCDRNTRPRLKKTCEKDTCDGPRVLQKLQADVPPIRWATGPWTACSATCGNGTQR 1389

  Fly   769 RKVECKQIMAQEHKIERPESMCPSA-KPADKKPCNVKPCP-------PEDPKPVIQINNSTHIQH 825
            |.::|:     :|..:.|:..|... |....:.|.::.|.       .|.|...     .||:|.
Worm  1390 RLLKCR-----DHVRDLPDEYCNHLDKEVSTRNCRLRDCSYWKMAEWEECPATC-----GTHVQQ 1444

  Fly   826 DPKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQ-RSRKYKVSKKGALRILD 889
            ....|.::.:.||..::     ..:.|.|::            :|.. |:.:.:...||...|..
Worm  1445 SRNVTCVSAEDGGRTIL-----KDVDCDVQK------------RPTSARNCRLEPCPKGEEHIGS 1492

  Fly   890 ITFRDAGVYSCHAG-------LSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSADM 947
            ....|....|...|       :|....|.:...|| :..::..::....|
Worm  1493 WIIGDWSKCSASCGGGWRRRSVSCTSSSCDETRKP-KMFDKCNEELCPPL--------------- 1541

  Fly   948 KSADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQ------------ 1000
                 |..|..:.|.:|.:.|. ..|.:||:...|.:.:||      |.|.::
Worm  1542 -----TNNSWQISPWTHCSVSC-GGGVQRRKIWCEDVLSGR------KQDDIECSEIKPREQRDC 1594

  Fly  1001 -------HADSSIMEDDLSQLVQSEDRIPQPASASSGGSRTRTLLAMPYFQALLSNLQLLWPLQR 1058
                   |..:......::.|..|.......|||||          :|....::|.....|....
Worm  1595 EMPPCRSHYHNKTSSASMTSLSSSNSNTTSSASASS----------LPILPPVVSWQTSAWSACS 1649

  Fly  1059 FKDSRGQHLLQGEALKFGIDLSGKDFDQDESERVPAEQLPPEVLHSPSDPEYHEPSKSGPEADVP 1123
            .|..||......|.:...::::....:.|:::: |.|::.....|.|
Worm  1650 AKCGRGTKRRVVECVNPSLNVTVASTECDQTKK-PVEEVRCRTKHCP------------------ 1695

  Fly  1124 HVPPHMPHARWETGAAASTTAVPSLPNDGFVYRWMLGEWSQCSQECGAAGSGLQRRTVSCQRAAK 1188
                     ||:|     ||                  ||.||..|   |.|::||.|.|.|..|
Worm  1696 ---------RWKT-----TT------------------WSSCSVTC---GRGIRRREVQCYRGRK 1725

  Fly  1189 ATSSGSTSDTENNVVDNSECF---------------------AHG-------------------- 1212
            ...|.|..:.:..:...:.||                     |.|
Worm  1726 NLVSDSECNPKTKLNSVANCFPVACPAYRWNVTPWSKCKDECARGQKQTRRVHCISTSGKRAAPR 1790

  Fly  1213 -LEL---PEFFQSCGNEACP-QWSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNGTEGSI----- 1267
             .||   |...:.|....|| :|..|||..|.:|...|    :|.|||.||.......:|
Worm  1791 MCELARAPTSIRECDTSNCPYEWVPGDWQTCSKSCGEG----VQTREVRCRRKINFNSTIPIIFM 1851

  Fly  1268 -----------CDEYERPAMRQECYNERC--EGVWRVEPWSECNAPCGRKGIKYRILQCVWYGSR 1319
                       |:.:.:|...|.|....|  |..|...||.||:..|| :||:.|.::||....|
Worm  1852 LEDEPAVPKEKCELFPKPNESQTCELNPCDSEFKWSFGPWGECSKNCG-QGIRRRRVKCVANDGR 1915

  Fly  1320 RPAGNVCKHQPRPAVMKVCKSPAC 1343
            |.....|..: :|...:.|....|
Worm  1916 RVERVKCTTK-KPRRTQYCFERNC 1938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	23/66 (35%)
		TSP1	546..600	CDD:214559	16/55 (29%)
		TSP1	750..807	CDD:214559	16/57 (28%)
		IGc2	845..902	CDD:197706	9/57 (16%)
		PLAC	1355..1384	CDD:285849
gon-1	NP_001255448.1	Pep_M12B_propep	93..228	CDD:279848
		Reprolysin	280..493	CDD:279729
		ZnMc_ADAMTS_like	280..490	CDD:239801
		TSP1	591..658	CDD:214559	23/66 (35%)
		ADAM_spacer1	769..885	CDD:283607	0/115 (0%)
		TSP1	1022..1077	CDD:214559	14/54 (26%)
		TSP1	1079..1129	CDD:214559	11/66 (17%)
		TSP1	1131..1185	CDD:214559	11/72 (15%)
		TSP1	1190..1242	CDD:214559	19/83 (23%)
		TSP1	1247..1296	CDD:214559	15/52 (29%)
		TSP1	1296..1354	CDD:214559	22/63 (35%)
		TSP1	1371..1424	CDD:214559	16/57 (28%)
		TSP1	1493..1539	CDD:214559	7/46 (15%)
		TSP1	1546..1599	CDD:214559	11/59 (19%)
		TSP1	1640..1695	CDD:214559	9/55 (16%)
		TSP1	1697..1751	CDD:214559	21/79 (27%)
		TSP1	1813..1881	CDD:214559	18/71 (25%)
		TSP1	1886..1938	CDD:214559	17/53 (32%)
		GON	1942..2137	CDD:285848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910