DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and gon-1

DIOPT Version :10

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_001255448.1 Gene:gon-1 / 177850 WormBaseID:WBGene00001650 Length:2165 Species:Caenorhabditis elegans


Alignment Length:1584 Identity:350/1584 - (22%)
Similarity:512/1584 - (32%) Gaps:550/1584 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGS---------------------CRGESTRYRICN 119
            |||..|..|..|||||.||:...:|.|.||.|                     |.|:..|||.||
 Worm   589 GQWGDWRSWGECSRTCGGGVQKGLRDCDSPKSENEVETLKSNVTSRPRNGGKYCVGQRERYRSCN 653

  Fly   120 MQPCP-EQQDFRSSQCSAYN--DVPYDG---TLYKWTPHYDYVEP---CALTCR--GHPA-HLVE 172
            .|.|| :.|.:|..|||.:|  |:...|   |...|.|.|..|.|   |.|.||  |..| :|:.
 Worm   654 TQECPWDTQPYREVQCSEFNNKDIGIQGVASTNTHWVPKYANVAPNERCKLYCRLSGSAAFYLLR 718

  Fly   173 DISRETGDGNAEEAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKID 237
            |                           :|.|||.|.....|:|:.|.|...|||.::.||.:.|
 Worm   719 D---------------------------KVVDGTPCDRNGDDICVAGACMPAGCDHQLHSTLRRD 756

  Fly   238 GCGVCGGDGNSC----------------------------------------------------- 249
            .|||||||.:||                                                     
 Worm   757 KCGVCGGDDSSCKVVKGTFNEQGTFGYNEVMKIPAGSANIDIRQKGYNNMKEDDNYLSLRAANGE 821

  Fly   250 ----------------------------------------------------------------- 249
                                                                             
 Worm   822 FLLNGHFQVSLARQQIAFQDTVLEYSGSDAIIERINGTGPIRSDIYVHVLSVGSHPPDISYEYMT 886

  Fly   250 -----------SQPLFNWEMA-PMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEAS 302
                       |..|:.|.:. ..::|...| .|.:..:.:|.:..|:....|..|....:|:.:
 Worm   887 AAVPNAVIRPISSALYLWRVTDTWTECDRAC-RGQQSQKLMCLDMSTHRQSHDRNCQNVLKPKQA 950

  Fly   303 VEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMC-RTPKPPTQETCI 366
            ...||. .|..|||.:|.|:||..||.|.:.:.|.|.:.....:|..::.:| |..||....:|.
 Worm   951 TRMCNI-DCSTRWITEDVSSCSAKCGSGQKRQRVSCVKMEGDRQTPASEHLCDRNSKPSDIASCY 1014

  Fly   367 IEECP--HWEVEDWTGCSVSCGQGIQM-RGVEC-----KSTDGSLSAK---------CDPLTKP- 413
            | :|.  .|...:||.||.:||...:| |...|     :..|.||..:         |:.:..| 
 Worm  1015 I-DCSGRKWNYGEWTSCSETCGSNGKMHRKSYCVDDSNRRVDESLCGREQKEATERECNRIPCPR 1078

  Fly   414 ---GSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDAD---------EDNEDEND 466
               |...:||..  |.|.:..               |..:.||::|.:         :..|..|:
 Worm  1079 WVYGHWSECSRS--CDGGVKM---------------RHAQCLDAADRETHTSRCGPAQTQEHCNE 1126

  Fly   467 EGDDVDDLESGQDTDD--GEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGE 529
            ............|...  |:|:.|.|......||:       ...|.|.:.:            |
 Worm  1127 HACTWWQFGVWSDCSAKCGDGVQYRDANCTDRHRS-------VLPEHRCLKM------------E 1172

  Fly   530 DESEGP---SLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLC--EGKKPH 589
            .....|   ...|.| |..|||.|||:|.:|...|..:|     .|.....|:.|||  ...:| 
 Worm  1173 KIITKPCHRESCPKY-KLGEWSQCSVSCEDGWSSRRVSC-----VSGNGTEVDMSLCGTASDRP- 1230

  Fly   590 DEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCV- 653
                 .....|.|                     |....||...:::||.||..|..|....|: 
 Worm  1231 -----ASHQTCNL---------------------GTCPFWRNTDWSACSVSCGIGHRERTTECIY 1269

  Fly   654 REDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRG 718
            ||.:   |....|.....||.. :||:..|| ..|..|.::|||.:||.||:||.|.|    |||
 Worm  1270 REQS---VDASFCGDTKMPETS-QTCHLLPC-TSWKPSHWSPCSVTCGSGIQTRSVSC----TRG 1325

  Fly   719 GDNTMVVPNSMCPQ-PPPADRQYCNVLDC--------------PVRWEVGEWSKCSHTCGYGFKD 768
            .:.| :|....|.: ..|..::.|....|              |:||..|.|:.||.|||.|.:.
 Worm  1326 SEGT-IVDEYFCDRNTRPRLKKTCEKDTCDGPRVLQKLQADVPPIRWATGPWTACSATCGNGTQR 1389

  Fly   769 RKVECKQIMAQEHKIERPESMCPSA-KPADKKPCNVKPCP-------PEDPKPVIQINNSTHIQH 825
            |.::|:     :|..:.|:..|... |....:.|.::.|.       .|.|...     .||:|.
 Worm  1390 RLLKCR-----DHVRDLPDEYCNHLDKEVSTRNCRLRDCSYWKMAEWEECPATC-----GTHVQQ 1444

  Fly   826 DPKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQ-RSRKYKVSKKGALRILD 889
            ....|.::.:.||..::     ..:.|.|::            :|.. |:.:.:...||...|..
 Worm  1445 SRNVTCVSAEDGGRTIL-----KDVDCDVQK------------RPTSARNCRLEPCPKGEEHIGS 1492

  Fly   890 ITFRDAGVYSCHAG-------LSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSADM 947
            ....|....|...|       :|....|.:...|| :..::..::....|               
 Worm  1493 WIIGDWSKCSASCGGGWRRRSVSCTSSSCDETRKP-KMFDKCNEELCPPL--------------- 1541

  Fly   948 KSADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQ------------ 1000
                 |..|..:.|.:|.:.|. ..|.:||:...|.:.:||      |.|.::            
 Worm  1542 -----TNNSWQISPWTHCSVSC-GGGVQRRKIWCEDVLSGR------KQDDIECSEIKPREQRDC 1594

  Fly  1001 -------HADSSIMEDDLSQLVQSEDRIPQPASASSGGSRTRTLLAMPYFQALLSNLQLLWPLQR 1058
                   |..:......::.|..|.......|||||          :|....::|.....|....
 Worm  1595 EMPPCRSHYHNKTSSASMTSLSSSNSNTTSSASASS----------LPILPPVVSWQTSAWSACS 1649

  Fly  1059 FKDSRGQHLLQGEALKFGIDLSGKDFDQDESERVPAEQLPPEVLHSPSDPEYHEPSKSGPEADVP 1123
            .|..||......|.:...::::....:.|:::: |.|::.....|.|                  
 Worm  1650 AKCGRGTKRRVVECVNPSLNVTVASTECDQTKK-PVEEVRCRTKHCP------------------ 1695

  Fly  1124 HVPPHMPHARWETGAAASTTAVPSLPNDGFVYRWMLGEWSQCSQECGAAGSGLQRRTVSCQRAAK 1188
                     ||:|     ||                  ||.||..|   |.|::||.|.|.|..|
 Worm  1696 ---------RWKT-----TT------------------WSSCSVTC---GRGIRRREVQCYRGRK 1725

  Fly  1189 ATSSGSTSDTENNVVDNSECF---------------------AHG-------------------- 1212
            ...|.|..:.:..:...:.||                     |.|                    
 Worm  1726 NLVSDSECNPKTKLNSVANCFPVACPAYRWNVTPWSKCKDECARGQKQTRRVHCISTSGKRAAPR 1790

  Fly  1213 -LEL---PEFFQSCGNEACP-QWSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNGTEGSI----- 1267
             .||   |...:.|....|| :|..|||..|.:|...|    :|.|||.||.......:|     
 Worm  1791 MCELARAPTSIRECDTSNCPYEWVPGDWQTCSKSCGEG----VQTREVRCRRKINFNSTIPIIFM 1851

  Fly  1268 -----------CDEYERPAMRQECYNERC--EGVWRVEPWSECNAPCGRKGIKYRILQCVWYGSR 1319
                       |:.:.:|...|.|....|  |..|...||.||:..|| :||:.|.::||....|
 Worm  1852 LEDEPAVPKEKCELFPKPNESQTCELNPCDSEFKWSFGPWGECSKNCG-QGIRRRRVKCVANDGR 1915

  Fly  1320 RPAGNVCKHQPRPAVMKVCKSPAC 1343
            |.....|..: :|...:.|....|
 Worm  1916 RVERVKCTTK-KPRRTQYCFERNC 1938

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 23/66 (35%)
TSP1_ADAMTS 256..311 CDD:465950 11/55 (20%)
TSP1_ADAMTS 315..370 CDD:465950 18/55 (33%)
TSP1_ADAMTS 373..420 CDD:465950 16/65 (25%)
TSP1 546..600 CDD:214559 16/55 (29%)
TSP1_ADAMTS 629..684 CDD:465950 17/55 (31%)
TSP1_ADAMTS 688..746 CDD:465950 21/58 (36%)
TSP1_ADAMTS 750..806 CDD:465950 16/56 (29%)
Ig 845..914 CDD:472250 12/76 (16%)
Ig strand B 848..852 CDD:409353 0/3 (0%)
Ig strand C 861..865 CDD:409353 0/3 (0%)
Ig strand E 883..887 CDD:409353 1/3 (33%)
Ig strand F 897..902 CDD:409353 1/4 (25%)
TSP1_ADAMTS 1157..1227 CDD:465950 23/114 (20%)
TSP1_ADAMTS 1289..1343 CDD:465950 17/53 (32%)
PLAC 1355..1384 CDD:462560
gon-1NP_001255448.1 Pep_M12B_propep 92..228 CDD:460254
ZnMc_ADAMTS_like 280..490 CDD:239801
ADAMTS_CR_2 508..577 CDD:465496
TSP1 591..658 CDD:214559 23/66 (35%)
ADAMTS_CR_3 668..768 CDD:437068 42/126 (33%)
ADAMTS_spacer1 770..886 CDD:461796 0/115 (0%)
TSP1_ADAMTS 962..1013 CDD:465950 16/50 (32%)
TSP1_ADAMTS 1022..1076 CDD:465950 14/53 (26%)
TSP1_ADAMTS 1079..1129 CDD:465950 11/66 (17%)
TSP1_ADAMTS 1132..1184 CDD:465950 11/70 (16%)
TSP1_ADAMTS 1190..1241 CDD:465950 19/82 (23%)
TSP1_ADAMTS 1244..1296 CDD:465950 17/55 (31%)
TSP1_ADAMTS 1299..1353 CDD:465950 21/58 (36%)
TSP1_ADAMTS 1371..1423 CDD:465950 16/56 (29%)
TSP1_ADAMTS 1426..1483 CDD:465950 12/78 (15%)
TSP1_ADAMTS 1493..1538 CDD:465950 7/45 (16%)
TSP1_ADAMTS 1546..1599 CDD:465950 11/59 (19%)
TSP1_ADAMTS 1640..1694 CDD:465950 8/54 (15%)
TSP1_ADAMTS 1697..1750 CDD:465950 21/78 (27%)
TSP1_ADAMTS 1755..1809 CDD:465950 6/53 (11%)
TSP1_ADAMTS 1813..1880 CDD:465950 18/70 (26%)
TSP1_ADAMTS 1886..1938 CDD:465950 17/53 (32%)
GON 1940..2137 CDD:462559
Blue background indicates that the domain is not in the aligned region.

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