DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and Y8A9A.2

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_001364778.1	Gene:	Y8A9A.2 / 173723	WormBaseID:	WBGene00021171	Length:	1358	Species:	Caenorhabditis elegans

Alignment Length:	846	Identity:	185/846 - (21%)
Similarity:	242/846 - (28%)	Gaps:	360/846 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCS-RTCD--GGIMHQMRRCGSPG--SCRGESTRYRICNM----------QPCPE 125
            |.|.:|.:||.|: .||.  ||...:.|.|.|..  ||.|::|....|.:          ..|
Worm   659 GIWGAWGEWSVCTGTTCGNCGGSRTRTRVCASDSFCSCNGDTTESENCRLLSSWSEWTTTGTC-- 721

  Fly   126 QQDFRSSQCSAYNDVPYDGTLYKWTPHY--------DYV--EPCA---LTCRGHPAHLVEDISRE 177
                ..:.|.....:.|..|..|....:        ||.  :|||   ..|....|..|:.:|.
Worm   722 ----NQTACGTCQTLTYTRTCLKTNGCFCMGSATKTDYCSRKPCATGTACCNSLTAQTVDGVSI- 781

  Fly   178 TGDGNAEEAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVC 242
              .|..|.||  ||           .|...|.:.:...|:.|   .|..:...|.... |.||.|
Worm   782 --CGPVEAAE--DE-----------TDPVPCTTTTPACCVLG---GVWSEWSSGDACN-DTCGNC 827

  Fly   243 G----------GDGN-SCSQPLFNWEMAPMSQCSVT---------CGSGYKMSRPICRNRLTNAD 287
            |          .|.| :||     ......|:|:..         ||:..|:   |.......:.
Worm   828 GVTTLSRVCLSQDYNCACS-----GSTTKQSECAPAPCPFPRTSCCGARKKV---IVGRTFECSS 884

  Fly   288 VDD------TLCSVTNRPEASVEQCNTHSCPPR---WIADDWST---CSRLCG------------ 328
            .||      |||:|         .|    ||..   |  .:|:|   |...||
Worm   885 ADDSDAAPSTLCAV---------DC----CPAAGGYW--SEWTTGGSCPTTCGSCSTVTQKRVCM 934

  Fly   329 -------HGYRERMVVCA-------EES--NGIKTRVADI--MC------RTPKPPTQETCIIEE 369
                   .|...|.|.|.       ::|  .|....|:..  :|      .||..|...||....
Worm   935 SPSTCPCQGVSSRSVNCGITVCYFPDDSCCAGYSATVSGTQHICGPQPNYTTPYAPYDPTCTDNC 999

  Fly   370 CPH---WEVEDWTG----CSVSCGQ-GIQMRGVECKS-TDGSLSAKCDPLTKPGSMQQCSTGI-- 423
            ||.   |  .|||.    |...||. |.|.|...|.| .||........:|:|     |.||:
Worm  1000 CPETGIW--SDWTSTPNQCRDYCGSCGNQTRTRTCTSDADGCPCQGPTTITEP-----CGTGVCY 1057

  Fly   424 -----HCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDG 483
                 .|.|....|.|          |:.....|.::.||
Worm  1058 FPRLSCCPGYTATVEG----------NQHICGPLTTAVAD------------------------- 1087

  Fly   484 EGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEW- 547
                                    ||:..|.                   |.|..|:.....||
Worm  1088 ------------------------PDKLNTC-------------------GVSCCPSAGIWGEWV 1109

  Fly   548 --SPCSVTCGE-GIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDD 609
              |.|:.|||. |...|...| :.|:|.        ..|.|......|  |....|:
Worm  1110 SVSGCNDTCGSCGQETRKRKC-LSLQYG--------CACTGNATDTSV--CASSVCL-------- 1155

  Fly   610 QFPRDSIKVGVS-----------------------------EPGKTYVWREQG-YTSCSASCLGG 644
             |||.|...|..                             :|.||.:|.:.| :|:|||:| ||
Worm  1156 -FPRTSCCTGFKKMVNITGRTFYCGPLPVVPAFNPEQTTCCDPEKTGLWNDWGAWTTCSATC-GG 1218

  Fly   645 VEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRP--CPPRWNYSDYTPCSKSCGIGIKTR 707
                                 |..:|    |.|||...|  ||...:.::...|:|.    :.|.
Worm  1219 ---------------------CGTQT----RSRTCASAPYGCPCTGDLTETQSCAKQ----VCTT 1254

  Fly   708 EVQCI--HEVTRGGDNTMVVPNSMCPQPPPADRQYC--NVLD-CPVRWEVGEWSK-----CSHTC 762
            ..||.  ..|..|.|..                |||  |..: |...|.  ||:.     |:.||
Worm  1255 GAQCCAGKFVATGYDGA----------------QYCQDNTPEVCTGTWT--EWATLEGAVCNDTC 1301

  Fly   763 G 763
            |
Worm  1302 G 1302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	17/60 (28%)
		TSP1	546..600	CDD:214559	16/57 (28%)
		TSP1	750..807	CDD:214559	7/19 (37%)
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
Y8A9A.2	NP_001364778.1	TSP1	1203..1252	CDD:214559	20/78 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910