DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nolo and madd-4

DIOPT Version :9

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_492405.3 Gene:madd-4 / 172706 WormBaseID:WBGene00009958 Length:1045 Species:Caenorhabditis elegans


Alignment Length:1337 Identity:361/1337 - (27%)
Similarity:515/1337 - (38%) Gaps:355/1337 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 WSSWSDWSTCSRTCDGGIMHQMRRCGSPGSCRGESTRYRICNMQPCPEQQDFRSSQCSAYNDVPY 142
            |::||.||:|::||.||:..|:||| ....|.|||.|:::|..:.|..:............::..
 Worm    26 WAAWSPWSSCTKTCGGGVSRQLRRC-LTSKCSGESVRFKVCAQKTCESKSRLARDTICGGEEIVS 89

  Fly   143 DGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLSARVQDGTR 207
            .|             .|.:.||          ||.||                .....||.|||.
 Worm    90 RG-------------QCEVVCR----------SRLTG----------------ANFLWRVDDGTP 115

  Fly   208 CRSG-SLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFNWEMA-PMSQCSVTC-- 268
            |::. |..:|.:|.||.||||..|.|:.:.|.||||||.|::|....|.|::: ..:.|:..|  
 Worm   116 CQAATSRAVCSKGSCQIVGCDGLISSSFRFDACGVCGGRGDTCDNGKFIWKVSEEYTACASNCDD 180

  Fly   269 -----GSGYKM---SRPI--CRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPP--RWIADDWS 321
                 |:|..:   |:||  |.|.:|...|.:.||:...||:.....|....||.  ||:|.||:
 Worm   181 IVDWSGAGRSIASTSQPIVVCVNAITGRVVPEKLCADKLRPKVEARPCPMLICPSRCRWMAADWT 245

  Fly   322 TCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRT-PKPPTQETCIIEECPHWEVEDWTGCSVSC 385
            .|...||.|.|:|.|.|.:.::.:...|.|..|.. .:|..:|.|:...|..||...|:.|:.||
 Worm   246 ECVPHCGEGTRKREVYCVQTAHNVTVHVPDTFCENGTRPAAEENCVSTSCGRWEAGKWSKCTASC 310

  Fly   386 GQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSER 450
            |||::.|.|.|  ..||   .||...:|.....|..||.|..:.|.:                  
 Worm   311 GQGVRRRHVAC--VGGS---DCDEGGRPRQETTCYAGIPCSIATNSL------------------ 352

  Fly   451 QLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMH 515
                        |.||.                   :|.|                         
 Worm   353 ------------DWNDR-------------------AYLD------------------------- 361

  Fly   516 LMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVND 580
               ||:..:.:...| .:.|.|     ...|||.||.|||.|:..||..|......|.....:..
 Worm   362 ---GNTFGSMDNHND-WQAPRL-----VAGEWSTCSSTCGTGVMSRTVECVAVNPISSAPIKLPM 417

  Fly   581 SLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGV 645
            |.|:.::.....|.|....|.|         ..||   .:||....|.||...:|.||||||||.
 Worm   418 SECQDQEQPKLFESCEVRSCPL---------QEDS---KLSEDEAPYQWRYGDWTQCSASCLGGK 470

  Fly   646 EELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQ 710
            ::..:.|::...|:.|....|....:|..:.|.||..||||.|..|.|:.||.|||.|...|.|:
 Worm   471 QKAALKCIQVSTGKSVQWSQCDARRRPPEKSRPCNQHPCPPFWLTSKYSDCSMSCGSGTARRSVK 535

  Fly   711 CIHEV--TRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVEC 773
            |...|  |.|.|..:|:.:..|....|.:.:.|||:.||..|...:|::||.:|..|.:.|:|.|
 Worm   536 CAQTVSKTDGADAHIVLRDDRCHFKKPQETETCNVVACPATWVTAQWTECSRSCDSGERRRQVWC 600

  Fly   774 KQIMAQEHKIERPESMC-PSAKPADKKPCNVKPCP-PEDPKPVIQINNSTHIQHDPKKTKITLKV 836
            :...::.....||:..| .:.||...:.|:...|. ||      .::|....|:..:| |:||.:
 Worm   601 EIRDSRGKTQRRPDVECDANTKPQTVEVCSFGSCSRPE------LLSNRVFEQNAEQK-KLTLGI 658

  Fly   837 GGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITFRDAGVYSCH 901
            ||...::.||.:|||||.|::::.||.|.|:.|.::.....|||..|.||:......|||||.|.
 Worm   659 GGVATLYQGTSIKIKCPAKKFDKKKIYWKKNGKKIKNDAHIKVSANGNLRVFHARMEDAGVYECF 723

  Fly   902 AGLSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSADMKSADGTGTSTAVGPNSHVN 966
                                       |:||       :...:.:.|..|...:...:.|...: 
 Worm   724 ---------------------------TDRL-------QGNVTLNFKYRDFPASRVDLAPKPQI- 753

  Fly   967 GSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSSIMEDDLSQLVQSEDRIPQPASASSGG 1031
                 ..::.||    |:|..:|...|.::..:...:.|::|                       
 Worm   754 -----PSTKNRQ----RVQVSKEDVLREQASVLHKMNVSLIE----------------------- 786

  Fly  1032 SRTRTLLAMPYFQALLSNLQLLWPLQRFKDSRGQHLLQGEALKFGIDLSGKDFDQDESERVPAEQ 1096
                .||..|                                            .||..|   ||
 Worm   787 ----ALLTAP--------------------------------------------NDEKAR---EQ 800

  Fly  1097 LPPEVLHSPSDPEYHEPSKSGPEADVPHVPPHMPHARWETGAAASTTAVPSLPNDGFVYRWMLGE 1161
            |                .|.|.|                                 .|.||.:|.
 Worm   801 L----------------RKYGNE---------------------------------LVARWDIGH 816

  Fly  1162 WSQCSQE-CGAAGSGLQRRTVSCQRAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQSCGNE 1225
            ||:|.|: |..|  |.|.|.:||    |.|..|     |...||||.|.:.....|...:.|..|
 Worm   817 WSECRQKTCHVA--GYQARGISC----KVTFHG-----EIRNVDNSICESLASVRPPETRPCHRE 870

  Fly  1226 ACPQWSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNGTEGSI--CDEYERPAMRQECYNERCEGV 1288
            .||:|....|:.|....|.....|.:||.||||:.|||...|  ||...|||...:|.|:.|:..
 Worm   871 DCPRWEASQWSECSSQRCVSSMLAQKRRNVTCRFTNGTSVDIQHCDITNRPATTMDCPNQNCKAE 935

  Fly  1289 WRVEPWSECNAPCGRKGIKYRILQCVWYGSRRPAGNVCKHQPRPAVMKVCKS----PACQAQLSS 1349
            ||...|..|::.||..|::.|:|.|||..|.||||..|:...||...:.|.:    |.|....|:
 Worm   936 WRTSDWGSCSSECGTGGVQLRLLSCVWISSGRPAGRNCEQMRRPHSARACVADEPLPPCMPTASA 1000

  Fly  1350 --SPAQLCRDSSRYCRNARAMGLCRLHRYKLKCCGSC 1384
              .....|:|.||:|...:....|.....:.|||.:|
 Worm  1001 LYQRDASCQDQSRFCDIIKLFHSCDSLEVRQKCCSTC 1037

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 20/45 (44%)
TSP1 546..600 CDD:214559 17/53 (32%)
TSP1 750..807 CDD:214559 15/57 (26%)
IGc2 845..902 CDD:197706 25/56 (45%)
PLAC 1355..1384 CDD:285849 9/28 (32%)
madd-4NP_492405.3 TSP1 26..71 CDD:214559 20/45 (44%)
TSP1 382..438 CDD:214559 17/55 (31%)
IGc2 666..723 CDD:197706 24/56 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 66 1.000 Domainoid score I6610
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H136318
Inparanoid 1 1.050 475 1.000 Inparanoid score I818
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG28675
OrthoDB 1 1.010 - - D26058at33208
OrthoFinder 1 1.000 - - FOG0004452
OrthoInspector 1 1.000 - - oto19541
orthoMCL 1 0.900 - - OOG6_106353
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R16940
SonicParanoid 1 1.000 - - X3156
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1211.910

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