DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nolo and ADAMTS17

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_016877462.1	Gene:	ADAMTS17 / 170691	HGNCID:	17109	Length:	1189	Species:	Homo sapiens

Alignment Length:	788	Identity:	187/788 - (23%)
Similarity:	271/788 - (34%)	Gaps:	261/788 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP-----GS-CRGESTRYRICNMQPCPE-QQDFRSSQ 133
            |.||.|..||.|||||..|...:.|:|.:|     |: |.|.|..:.:|...|||: ...||..|
Human   588 GDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQ 652

  Fly   134 CSAYNDV-PYDGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQ 197
            |.|::.: |....|.......|  :||.|.|        ..:.:|:.                :.
Human   653 CQAHDRLSPKKKGLLTAVVVDD--KPCELYC--------SPLGKESP----------------LL 691

  Fly   198 LSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFNWEMAPMS 262
            ::.||.|||.|.....|:|:.||||::|||..|||..|.|.||||.|||.:|
Human   692 VADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTC------------- 743

  Fly   263 QCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLC 327
                               .|...|......:|.|.....|..|......|:            |
Human   744 -------------------HLVKGDFSHARGTVKNDLCTKVSTCVMAEAVPK------------C 777

  Fly   328 GHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEV-EDWTGCSVSCGQGIQM 391
            ...|.|..|:.|   ...:.||.:      ..|......:::.....: .||
Human   778 FSCYIEAAVIPA---GARRIRVVE------DKPAHSFLALKDSGKGSINSDW------------- 820

  Fly   392 RGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSD 456
                             .:..||..|              :.||.:....|.|.|:
Human   821 -----------------KIELPGEFQ--------------IAGTTVRYVRRGLWEK--------- 845

  Fly   457 ADEDNEDENDEGDDVDDLESGQDT------------DDGEGLSYADQPLLYAHRTQSRLNQEAPD 509
                             :.:...|            |...|:.|  :..:..:||..  ||..|:
Human   846 -----------------ISAKGPTKLPLHLMVLLFHDQDYGIHY--EYTVPVNRTAE--NQSEPE 889

  Fly   510 EPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYI-KDNEWSPCSVTCGEGIRRRTYNCKIFLEYSR 573
            :|:                         |..:| ..:.|..|||.||.|.||...:|...:  ::
Human   890 KPQ-------------------------DSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIV--NK 927

  Fly   574 TVATVNDSLC-EGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSC 637
            |...||||.| :..:|..:|.||...||...                         |....::.|
Human   928 TTTLVNDSDCPQASRPEPQVRRCNLHPCQSR-------------------------WVAGPWSPC 967

  Fly   638 SASCLGGVEELIINCVRE-DNGRVVS--PFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKS 699
            ||:|..|.:...:.||.: .||..|:  |..| |..:| |.|::|..:.|...|..|:::.||.|
Human   968 SATCEKGFQHREVTCVYQLQNGTHVATRPLYC-PGPRP-AAVQSCEGQDCLSIWEASEWSQCSAS 1030

  Fly   700 CGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGY 764
            ||.|:..|.|.|.:...:...:|.       |:...|...|....:    |:.|:||.||.|||.
Human  1031 CGKGVWKRTVACTNSQGKCDASTR-------PRAEEACEDYSGCYE----WKTGDWSTCSSTCGK 1084

  Fly   765 GFKDRKVECKQIMAQEHKIE-RPESMCPS-AKPADKKPCNVKPCPPEDPKPVIQINNSTHIQHDP 827
            |.:.|.|:|.      ||:. |..|.||: :|||..:.|..:.|...     |..|..|    .|
Human  1085 GLQSRVVQCM------HKVTGRHGSECPALSKPAPYRQCYQEVCNDR-----INANTIT----SP 1134

  Fly   828 KKTKITLK 835
            :...:|.|
Human  1135 RLAALTYK 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	20/51 (39%)
		TSP1	546..600	CDD:214559	20/54 (37%)
		TSP1	750..807	CDD:214559	23/58 (40%)
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
ADAMTS17	XP_016877462.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810