DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nolo and WFIKKN2

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_783165.1	Gene:	WFIKKN2 / 124857	HGNCID:	30916	Length:	576	Species:	Homo sapiens

Alignment Length:	304	Identity:	61/304 - (20%)
Similarity:	90/304 - (29%)	Gaps:	99/304 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   665 LCSPETKPEARV---RTCNDRPCPPRWNYSDYTPC------SKSC-------------GIGIKTR 707
            :|..:..|...|   .||. |.|........|..|      :|||             .:|: .:
Human    45 ICPNDMNPNLWVDAQSTCR-RECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGM-PK 107

  Fly   708 EVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNVLD------CPVRWE-----------VGEW 755
            |..|.|              .||.|    ....|::.|      |..|.|           :..:
Human   108 EATCDH--------------FMCLQ----QGSECDIWDGQPVCKCKDRCEKEPSFTCASDGLTYY 154

  Fly   756 SKC---SHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCPPE-DPKPVIQ 816
            ::|   :..|..|.....|.|:      :....|.: .|........|....|..|| |......
Human   155 NRCYMDAEACSKGITLAVVTCR------YHFTWPNT-SPPPPETTMHPTTASPETPELDMAAPAL 212

  Fly   817 INNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKD--------HKPLQR 873
            :||..|       ..:|:          |..|...|.|....|.:|.|.|.        .:|...
Human   213 LNNPVH-------QSVTM----------GETVSFLCDVVGRPRPEITWEKQLEDRENVVMRPNHV 260

  Fly   874 SRKYKVSKKGALRILDITFRDAGVYSCH----AGLSSAEISIEV 913
            .....|:....|.|.:...:|||:|:|.    ||:..|:..:.|
Human   261 RGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADFPLSV 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559
		TSP1	546..600	CDD:214559
		TSP1	750..807	CDD:214559	10/70 (14%)
		IGc2	845..902	CDD:197706	17/68 (25%)
		PLAC	1355..1384	CDD:285849
WFIKKN2	NP_783165.1	WAP	44..90	CDD:278522	12/45 (27%)
		KAZAL_FS	138..174	CDD:238052	4/35 (11%)
		I-set	216..304	CDD:254352	22/104 (21%)
		Ig_3	224..304	CDD:143242	20/79 (25%)
		Kunitz_BPTI	328..379	CDD:278443
		Kunitz_BPTI	385..436	CDD:278443
		NTR_WFIKKN	455..563	CDD:239630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900