DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and WFIKKN1

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_444514.1	Gene:	WFIKKN1 / 117166	HGNCID:	30912	Length:	548	Species:	Homo sapiens

Alignment Length:	290	Identity:	57/290 - (19%)
Similarity:	89/290 - (30%)	Gaps:	97/290 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   679 CNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQC------------IHE-VTRGGDNTMVVPNS-- 728
            |.::..|..|..:..| |.:.|     :|:..|            :|. |......:...|.:
Human    33 CPNQLSPNLWVDAQST-CEREC-----SRDQDCAAAEKCCINVCGLHSCVAARFPGSPAAPTTAA 91

  Fly   729 -----MCPQPPPADRQYCNVLD------CPVRWE-----------VGEWSKC---SHTCGYGFKD 768
                 :|||    ....|::.|      |..|.|           :..:::|   :..|..|...
Human    92 SCEGFVCPQ----QGSDCDIWDGQPVCRCRDRCEKEPSFTCASDGLTYYNRCYMDAEACLRGLHL 152

  Fly   769 RKVECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCPP---EDPKPVIQINNSTHIQHDPKKT 830
            ..|.||.:::..     |.|..|....|...| ...|.||   ..|.|.
Human   153 HIVPCKHVLSWP-----PSSPGPPETTARPTP-GAAPVPPALYSSPSPQ---------------- 195

  Fly   831 KITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDH--------KPLQRSRKYKVSKKGALRI 887
              .::|||.        ..:.|.|.......:.|.|..        :|.|......|:..|.|.:
Human   196 --AVQVGGT--------ASLHCDVSGRPPPAVTWEKQSHQRENLIMRPDQMYGNVVVTSIGQLVL 250

  Fly   888 LDITFRDAGVYSC----HAGLSSAEISIEV 913
            .:....|||:|:|    .|||..|:..:.|
Human   251 YNARPEDAGLYTCTARNAAGLLRADFPLSV 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559
		TSP1	546..600	CDD:214559
		TSP1	750..807	CDD:214559	13/70 (19%)
		IGc2	845..902	CDD:197706	14/68 (21%)
		PLAC	1355..1384	CDD:285849
WFIKKN1	NP_444514.1	WAP	29..76	CDD:306578	9/48 (19%)
		KAZAL_FS	120..155	CDD:238052	4/34 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..184		5/25 (20%)
		Ig_3	200..280	CDD:143242	20/87 (23%)
		KU	307..351	CDD:294074
		Kunitz_BPTI	358..409	CDD:278443
		NTR_WFIKKN	427..537	CDD:239630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900