DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nolo and Adamts1

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_033751.3	Gene:	Adamts1 / 11504	MGIID:	109249	Length:	968	Species:	Mus musculus

Alignment Length:	448	Identity:	127/448 - (28%)
Similarity:	178/448 - (39%)	Gaps:	143/448 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP-----GS-CRGESTRYRICNMQPCPEQ--QDFRSS 132
            |.|..|..|..|||||.||:.:.||.|.:|     |. |.|:..|||.||::.||:.  :.||..
Mouse   561 GSWGPWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNIEDCPDNNGKTFREE 625

  Fly   133 QCSAYNDVPY----DGTLYKWTPHYDYVEP---CALTCRGHPAHLVEDISRETGDGNAEEAEHYD 190
            ||.|:|:...    :....:|||.|..|.|   |.|||..            .|.|
Mouse   626 QCEAHNEFSKASFGNEPTVEWTPKYAGVSPKDRCKLTCEA------------KGIG--------- 669

  Fly   191 EQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFN 255
               ....|..:|.|||.|...|..:|:||:|.:.|||..|.|.||.|.||||||:|::|.:
Mouse   670 ---YFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKK---- 727

  Fly   256 WEMAPMSQCSVTCGSGYK--MSRPICRNRLTNADV--------------------DDTLCSVTNR 298
                 ||....:...||.  ::.|.   ..||.:|                    |.|.....|.
Mouse   728 -----MSGIVTSTRPGYHDIVTIPA---GATNIEVKHRNQRGSRNNGSFLAIRAADGTYILNGNF 784

  Fly   299 PEASVEQCNT------------------------------------HSCPPR------------- 314
            ..:::||..|                                    |:..|:
Mouse   785 TLSTLEQDLTYKGTVLRYSGSSAALERIRSFSPLKEPLTIQVLMVGHALRPKIKFTYFMKKKTES 849

  Fly   315 ---------WIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEEC 370
                     |:.::|..||:.||.|::.|:|.|.:    |....|....:..||.:...|....|
Mouse   850 FNAIPTFSEWVIEEWGECSKTCGSGWQRRVVQCRD----INGHPASECAKEVKPASTRPCADLPC 910

  Fly   371 PHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSL--SAKCDPLTKPG------SMQQCS 420
            |||:|.||:.||.:||:|.:.|.::|.|.||.:  :..||||.||.      ::.|||
Mouse   911 PHWQVGDWSPCSKTCGKGYKKRTLKCVSHDGGVLSNESCDPLKKPKHYIDFCTLTQCS 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	22/51 (43%)
		TSP1	546..600	CDD:214559
		TSP1	750..807	CDD:214559
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
Adamts1	NP_033751.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Pep_M12B_propep	70..194	CDD:279848
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..253
		Cysteine switch. /evidence=ECO:0000250	204..211
		Reprolysin	259..468	CDD:279729
		ZnMc_ADAMTS_like	259..464	CDD:239801
		ADAM_CR	469..549	CDD:301627
		ADAM_CR	530..699	CDD:301627	54/161 (34%)
		TSP1	563..615	CDD:214559	22/51 (43%)
		Spacer	726..850		16/135 (12%)
		ADAM_spacer1	726..843	CDD:283607	16/128 (13%)
		TSP1	857..911	CDD:214559	15/57 (26%)
		TSP1	912..>954	CDD:214559	19/41 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900