DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nolo and ADAMTS6

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_922932.2	Gene:	ADAMTS6 / 11174	HGNCID:	222	Length:	1117	Species:	Homo sapiens

Alignment Length:	760	Identity:	182/760 - (23%)
Similarity:	254/760 - (33%)	Gaps:	309/760 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 QSAGGGGGAGGGPGQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQ 121
            ||..||         |..||.|..|||||.||:...:|.|.||..      |.||..|||.||..
Human   555 QSIDGG---------WGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTD 610

  Fly   122 PCP-EQQDFRSSQCSAYNDVPYDGTLYKWTPHY-DYVEPCALTCRGHPAHLVEDISRETGDGNAE 184
            ||| ..:|||..||:.::::|:.|..|.|.|:. ..|:||||.|.                  ||
Human   611 PCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCL------------------AE 657

  Fly   185 EAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC 249
            ....|.|:      :..|.|||:|.:.|||:||.|:|:.||||..:||..:.|.|.||||||::|
Human   658 GYNFYTER------APAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTC 716

  Fly   250 S--QPLFNWEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCP 312
            .  :..|| :..|.        .||                    ..|...|..||.
Human   717 DAIEGFFN-DSLPR--------GGY--------------------MEVVQIPRGSVH-------- 744

  Fly   313 PRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEVED 377
                              ...|.|..::....:|:...|......               |.: |
Human   745 ------------------IEVREVAMSKNYIALKSEGDDYYINGA---------------WTI-D 775

  Fly   378 WTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSR 442
            |                                  |.......|..|
Human   776 W----------------------------------PRKFDVAGTAFH------------------ 788

  Fly   443 SLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEA 507
                                                                |...|
Human   789 ----------------------------------------------------YKRPT-------- 793

  Fly   508 PDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGE---GIRRRTYNCKIFL 569
             |||.::                |:.||:.:...:        .|...|   |||.: :|..|
Human   794 -DEPESL----------------EALGPTSENLIV--------MVLLQEQNLGIRYK-FNVPI-- 830

  Fly   570 EYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGY 634
              :||.:                                          |.:|.|  :.|..|.:
Human   831 --TRTGS------------------------------------------GDNEVG--FTWNHQPW 849

  Fly   635 TSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKS 699
            :.|||:|.|||:...:.|.|.|:..:|....|.|::||....|.||..||||.|...|:..|||:
Human   850 SECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKT 914

  Fly   700 CGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGY 764
            |..|::||.|.||.::....:.|:  ..|.|....|.:::.||...||.:|...:||:|:..||.
Human   915 CDGGMRTRAVLCIRKIGPSEEETL--DYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGP 977

  Fly   765 GFKDRKVECKQIMAQEHKIERPESMCP-SAKPADKKPCNVKPCPP 808
            |||.|.|.||   :.:.....|.:.|| .:||..:..|::..|||
Human   978 GFKHRIVLCK---SSDLSKTFPAAQCPEESKPPVRIRCSLGRCPP 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	24/51 (47%)
		TSP1	546..600	CDD:214559	9/56 (16%)
		TSP1	750..807	CDD:214559	19/57 (33%)
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
ADAMTS6	NP_922932.2	Pep_M12B_propep	69..190	CDD:279848
		Reprolysin	250..468	CDD:279729
		ZnMc_ADAMTS_like	250..465	CDD:239801
		TSP1	561..613	CDD:214559	24/51 (47%)
		Spacer	717..843		39/382 (10%)
		ADAM_spacer1	719..829	CDD:283607	33/318 (10%)
		TSP1	848..900	CDD:214559	19/51 (37%)
		TSP1	902..960	CDD:214559	18/59 (31%)
		TSP1	1022..1069	CDD:214559
		PLAC	1083..1115	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11783
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810