Protein Alignment nolo and ADAMTS6

DIOPT Version :10

• Sequence 1: NP_001036374.1
• Gene: nolo / 35424
• FlyBaseID: FBgn0051619
• Length: 1394
• Species: Drosophila melanogaster
• Sequence 2: NP_922932.2
• Gene: ADAMTS6 / 11174
• HGNCID: 222
• Length: 1117
• Species: Homo sapiens
• Alignment Length: 144
• Identity: 41/144 - (28%)
• Similarity: 55/144 - (38%)
• Gaps: 37/144 - (25%)

  Fly    16 IGAGPAGL----VAARELRREGHSVVVFEKQKQVGGTWIYTDEVESDPLSVDPTRSVVHSSVYRS 76
            ||..|.||    ..|.::..:..|.|     |.|..|.:..:||.:.|  |.||          .
Human   214 IGEEPWGLSQLDSGAGDISTDATSDV-----KIVIKTEVQEEEVVATP--VHPT----------D 261

  Fly    77 LRINGTRECTGY--RDFPFVVRSGVSRDR-RRFPSHGEVLAYLKDFAKEFGIEEMVRFETEVVKV 138
            |..:||....|.  |.||..|:.|....: ..|||...||          |:.|..|.|.::.::
Human   262 LEAHGTLFAPGQATRFFPSPVQEGAWESQGSSFPSQDPVL----------GLREPTRPERDIGEL 316

  Fly   139 SPA---AEEGIGKW 149
            |||   .|...|.|
Human   317 SPAIAQEEAPAGDW 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	13/48 (27%)
		TSP1_ADAMTS	256..311	CDD:465950
		TSP1_ADAMTS	315..370	CDD:465950
		TSP1_ADAMTS	373..420	CDD:465950
		TSP1	546..600	CDD:214559
		TSP1_ADAMTS	629..684	CDD:465950
		TSP1_ADAMTS	688..746	CDD:465950
		TSP1_ADAMTS	750..806	CDD:465950
		Ig	845..914	CDD:472250
		Ig strand B	848..852	CDD:409353
		Ig strand C	861..865	CDD:409353
		Ig strand E	883..887	CDD:409353
		Ig strand F	897..902	CDD:409353
		TSP1_ADAMTS	1157..1227	CDD:465950
		TSP1_ADAMTS	1289..1343	CDD:465950
		PLAC	1355..1384	CDD:462560
ADAMTS6	NP_922932.2	Pep_M12B_propep	43..191	CDD:460254
		ZnMc_ADAMTS_like	250..465	CDD:239801	30/103 (29%)
		ADAMTS_CR_2	480..548	CDD:465496
		TSP1	561..613	CDD:214559
		ADAMTS_CR_3	618..716	CDD:437068
		Spacer	717..843
		ADAMTS_spacer1	719..829	CDD:461796
		TSP1_ADAMTS	844..899	CDD:465950
		TSP1_ADAMTS	903..959	CDD:465950
		TSP1_ADAMTS	963..1017	CDD:465950
		TSP1_ADAMTS	1022..1071	CDD:465950
		PLAC	1083..1115	CDD:462560