DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nolo and ADAMTS5

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_008969.2	Gene:	ADAMTS5 / 11096	HGNCID:	221	Length:	930	Species:	Homo sapiens

Alignment Length:	394	Identity:	103/394 - (26%)
Similarity:	147/394 - (37%)	Gaps:	130/394 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPCPEQ-QDFRSSQ 133
            |.|.||..|..|||:|.||:....|.|.:|..      |.|:...||.|::.|||.. :.||..|
Human   568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQ 632

  Fly   134 CSAYNDVPYDG----TLYKWTPHYDYVEP---CALTCRGHPAHLVEDISRETGDGNAEEAEHYDE 191
            |.|.|....|.    |..:|.|.|..|.|   |.||||          ::.||        :|
Human   633 CEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCR----------AKGTG--------YY-- 677

  Fly   192 QSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPL--F 254
                |..|.:|.|||.||..|..:|::|||.|.|||..|||..:.|.|||||||.:||::.:  |
Human   678 ----VVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTF 738

  Fly   255 NWE-------------------------------------------------MAPMSQCSVTC-- 268
            |.:                                                 |...|:..:..
Human   739 NKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDING 803

  Fly   269 ----------------GSGYKMSRPICRNRLTNADVDDTL----------------CSVTNRPEA 301
                            |.||..::.|...::...|....|                .|||:....
Human   804 TVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSN 868

  Fly   302 SVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCI 366
            .|   .:|:..|:|:...|..|||.|..|:..|.|.|.:.:.    ::|.....:.:|...:.|:
Human   869 KV---GSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNR----KLAKGCPLSQRPSAFKQCL 926

  Fly   367 IEEC 370
            :::|
Human   927 LKKC 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	19/51 (37%)
		TSP1	546..600	CDD:214559
		TSP1	750..807	CDD:214559
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
ADAMTS5	NP_008969.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..69
		Pep_M12B_propep	67..168	CDD:307618
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..231
		Cysteine switch. /evidence=ECO:0000250	207..214
		ZnMc_ADAMTS_like	269..473	CDD:239801
		TSP1	570..622	CDD:214559	19/51 (37%)
		Spacer	732..874		14/144 (10%)
		ADAM_spacer1	732..852	CDD:310520	10/119 (8%)
		TSP1	879..930	CDD:214559	13/54 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810