DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nolo and ADAMTS8

DIOPT Version :9

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:NP_008968.4 Gene:ADAMTS8 / 11095 HGNCID:224 Length:889 Species:Homo sapiens


Alignment Length:552 Identity:135/552 - (24%)
Similarity:189/552 - (34%) Gaps:197/552 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 VNMNWTSPKIW---AALFVTTL-------CLLDTQAA--------------WAKKLNASQAFDDT 43
            |::|.|.|  |   :|:::|.|       ||||..||              :.......|.|...
Human   397 VHLNQTLP--WSPCSAMYLTELLDGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPD 459

  Fly    44 W----NT-ASDLENEL-------EQQKRSKVQSAGGGGGAGGGPGQ------------------- 77
            :    || |.|:..:|       |....:|..|.....|...|||.                   
Human   460 FRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPV 524

  Fly    78 ----WSSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPC-PEQQDFRS 131
                |:.|..|..|||||.||:....|.|..|..      |.|...:|:.|:.:.| |:.:.||.
Human   525 ADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFRE 589

  Fly   132 SQCSAYNDVPY---DGTLYKWTPHYDYVEP---CALTCRGHPAHLVEDISRETGDGNAEEAEHYD 190
            .||..||...|   ||.|.:|.|.|..|.|   |.|.||..              |.:|      
Human   590 QQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRAR--------------GRSE------ 634

  Fly   191 EQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFN 255
                .....|:|.|||.|...:|.:|::|:|.:.|||..:.|.:|:|.||||||.||||.:  .:
Human   635 ----FKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRK--VS 693

  Fly   256 WEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDW 320
            ..:.|.:.       ||        |.:.......|...|..|....|:             :|.
Human   694 GSLTPTNY-------GY--------NDIVTIPAGATNIDVKQRSHPGVQ-------------NDG 730

  Fly   321 STCSRLCGHG---YRERMVVCAEESNGIKTRVADIMCR---------------------TPKPPT 361
            :..:.....|   ....:.:.|.|.        ||:.:                     .|:|.|
Human   731 NYLALKTADGQYLLNGNLAISAIEQ--------DILVKGTILKYSGSIATLERLQSFRPLPEPLT 787

  Fly   362 QE-----------------------------------TCIIEECPH--WEVEDWTGCSVSCGQGI 389
            .:                                   |.||:...|  |.:.||:.||.:||.|.
Human   788 VQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGW 852

  Fly   390 QMRGVECKSTDGSLSAKCDPLTKPGSMQQCST 421
            |.|.|||:...|..||.|:...||...:.|.:
Human   853 QRRTVECRDPSGQASATCNKALKPEDAKPCES 884

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559 18/52 (35%)
TSP1 546..600 CDD:214559
TSP1 750..807 CDD:214559
IGc2 845..902 CDD:197706
PLAC 1355..1384 CDD:285849
ADAMTS8NP_008968.4 Pep_M12B_propep 50..150 CDD:279848
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..210
Reprolysin 219..429 CDD:279729 12/33 (36%)
ZnMc_ADAMTS_like 219..426 CDD:239801 9/30 (30%)
ADAM_CR 448..514 CDD:301627 14/65 (22%)
TSP1 529..581 CDD:214559 17/51 (33%)
Spacer 690..831 20/178 (11%)
ADAM_spacer1 690..809 CDD:283607 17/156 (11%)
TSP1 836..888 CDD:214559 20/49 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11783
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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