DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and Adamts7

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_001313280.1	Gene:	Adamts7 / 108153	MGIID:	1347346	Length:	1657	Species:	Mus musculus

Alignment Length:	1527	Identity:	326/1527 - (21%)
Similarity:	473/1527 - (30%)	Gaps:	629/1527 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP-----GS-CRGESTRYRICNMQPC-PEQQDFRSSQ 133
            |.||.||.||.|||:|..|:....|:|..|     |. |.||..|.::||:..| |::..||.:|
Mouse   524 GGWSGWSAWSDCSRSCGVGVRSSERQCTQPVPKNRGKYCVGERKRSQLCNLPACPPDRPSFRHTQ 588

  Fly   134 CSAYNDVPYDGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQL 198
            ||.::.:.|.|.|:||.|..:...||.|.||               ..|:...|         :|
Mouse   589 CSQFDGMLYKGKLHKWVPVPNDDNPCELHCR---------------PSNSSNTE---------KL 629

  Fly   199 SARVQDGTRCRSG--SLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC------------ 249
            ...|.|||.|...  |.|:|:.|.|:.||||..|.|..:.|.||||.|||::|
Mouse   630 RDAVVDGTPCYQSRISRDICLNGICKNVGCDFVIDSGAEEDRCGVCRGDGSTCQTVSRTFKETEG 694

  Fly   250 ----------------------------------------------------------------- 249

Mouse   695 QGYVDIGLIPAGAREILIEEVAEAANFLALRSEDPDKYFLNGGWTIQWNGDYRVAGTTFTYARKG 759

  Fly   250 -----------SQPL-------------------------------FNWEMAPMSQCSVTCGSGY 272
                       |:|:                               |:|...|.|:|:||||:|.
Mouse   760 NWENLTSPGPTSEPVWIQLLFQEKNPGVHYQYTIQRDSHDQVRPPEFSWHYGPWSKCTVTCGTGV 824

  Fly   273 KMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCG-HGYRERMV 336
            :.....|..|.... |.:..|:..|||:....:|:...|||||.|.:|..|||.|| .|...|.|
Mouse   825 QRQSLYCMERQAGV-VAEEYCNTLNRPDERQRKCSEEPCPPRWWAGEWQPCSRSCGPEGLSRRAV 888

  Fly   337 VCAEESNGIKTRVADIMC--RTPKPPTQETC---IIEECPH-WEVEDWTGCSVSCGQGIQMRGVE 395
            .|.......:.|..::..  ..|:|..:..|   :|  ||. |.|.:|:.|||:||.||:.|.|.
Mouse   889 FCIRSMGLDEQRALELSACEHLPRPLAETPCNRHVI--CPSTWGVGNWSQCSVTCGAGIRQRSVL 951

  Fly   396 C-KSTDGSLSAKCDPLTKPGS-----MQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDS 454
            | .:||    ..||...:|.:     :|.|...::          .:..|:|.|         .|
Mouse   952 CINNTD----VPCDEAERPITETFCFLQPCQYPMY----------IVDTGASGS---------GS 993

  Fly   455 SDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAP-----DEPRTM 514
            |..:..||        ||.:.                            ||.||     ..|:.:
Mouse   994 SSPELFNE--------VDFIP----------------------------NQLAPRPSPASSPKPV 1022

  Fly   515 HLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVN 579
            .:.|...       |:|.:.|.  |.::.|..:.              ||   |:.:       :
Mouse  1023 SISNAID-------EEELDPPG--PVFVDDFYYD--------------YN---FINF-------H 1054

  Fly   580 DSLCEG--KKPHDEVERCVED------PCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTS 636
            :.|..|  ::||.::   |::      |.:.|:....|.....:..:|.........|......|
Mouse  1055 EDLSYGSFEEPHPDL---VDNGGWTAPPHIRPTESPSDTPVPTAGALGAEAEDIQGSWSPSPLLS 1116

  Fly   637 CSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCG 701
            .::....|:|:..||        .::.||...:|...|........|.||.......||
Mouse  1117 EASYSPPGLEQTSIN--------PLANFLTEEDTPMGAPELGFPSLPWPPASVDDMMTP------ 1167

  Fly   702 IGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGF 766
                         |..|..:.::|...  .|.||:.                .||
Mouse  1168 -------------VGPGNPDELLVKED--EQSPPST----------------PWS---------- 1191

  Fly   767 KDRKVECKQIMAQEHKIERPESMCPSAKPA-DKKPCNVKPCPPE------DPKP-VIQINNSTHI 823
             ||           :|:....:......|| .:.|...:|.||.      .|.| |::::...:.
Mouse  1192 -DR-----------NKLSTDGNPLGHTSPALPQSPIPTQPSPPSISPTQASPSPDVVEVSTGWNA 1244

  Fly   824 QHDP----------KKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYK 878
            ..||          .:...|::|....|:...|...|             |.:| .||:....
Mouse  1245 AWDPVLEADLKPGHGELPSTVEVASPPLLPMATVPGI-------------WGRD-SPLEPGTP-- 1293

  Fly   879 VSKKGALRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTEALT 943
                        ||            ||.|:|       .|.::.|..          .||..||
Mouse  1294 ------------TF------------SSPELS-------SQHLKTLTM----------PGTLLLT 1317

  Fly   944 -SADMKSADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSSIM 1007
             ..|::|.         ||:.              |.|:..|:.
Mouse  1318 VPTDLRSP---------GPSG--------------QPQTPNLEG--------------------- 1338

  Fly  1008 EDDLSQLVQSEDRIPQPASASSGGSRTRTLLAMPYFQALLSNLQLLWPLQRFKDSRGQHLLQGEA 1072
                   .||...:|.||      ..|:|
Mouse  1339 -------TQSPGLLPTPA------RETQT------------------------------------ 1354

  Fly  1073 LKFGIDLSGKDFDQDESERVPAEQLPPEVLHSPSDPEYHEPSKSGPEADVPHVPPHMPHARWETG 1137
                  .|.||               |||  .|..|...|   .|..||    |....:|.|:.|
Mouse  1355 ------NSSKD---------------PEV--QPLQPSLEE---DGDPAD----PLPARNASWQVG 1389

  Fly  1138 --AAASTTAVPSLPNDGFVYR-------------------------------WMLGEWSQCSQEC 1169
              :..|||.     ..|.::|                               |..|.||:||:.|
Mouse  1390 NWSQCSTTC-----GLGAIWRLVSCSSGNDEDCTLASRPQPARHCHLRPCAAWRTGNWSKCSRNC 1449

  Fly  1170 GAAGSGLQRRTVSCQRAAKATSSGSTSDTENNVVDNSE--------CFAHGLELPEFFQSCGNEA 1226
               |.|...|.|.|                   ||..:        | ..|...|...|.||.:.
Mouse  1450 ---GGGSSTRDVQC-------------------VDTRDLRPLRPFHC-QPGPTKPPNRQLCGTQP 1491

  Fly  1227 CPQWSKGDWTPCQRSHCHGRNTAMQRREVTCRYPNGTEGSICDEYERPAMRQECYNERCEGVWRV 1291
            |..|....|..|..: |.|   ..|:|.|||..|     .:|:|..||...:.|....|. .|.|
Mouse  1492 CLPWYTSSWRECSEA-CGG---GEQQRLVTCPEP-----GLCEESLRPNNSRPCNTHPCT-QWVV 1546

  Fly  1292 EPWSECNAPCGRKGIKYRILQCV--WYGSRRPAGNVCKHQPRPAVMKVCKSPACQAQLSSSPAQL 1354
            .||.:|:|||| .|::.|:::||  ..|......::|.|:..|...:.|.:..|:.   ..|.:.
Mouse  1547 GPWGQCSAPCG-GGVQRRLVRCVNTQTGLAEEDSDLCSHEAWPESSRPCATEDCEL---VEPPRC 1607

  Fly  1355 CRD--SSRYCRNARAMGLCRLHRYKLKCCGSC 1384
            .||  |..:|...|.:|.|:|...:.:||.||
Mouse  1608 ERDRLSFNFCETLRLLGRCQLPTIRAQCCRSC 1639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	22/52 (42%)
		TSP1	546..600	CDD:214559	8/61 (13%)
		TSP1	750..807	CDD:214559	9/57 (16%)
		IGc2	845..902	CDD:197706	8/56 (14%)
		PLAC	1355..1384	CDD:285849	10/30 (33%)
Adamts7	NP_001313280.1	Pep_M12B_propep	58..173	CDD:279848
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..221
		Cysteine switch. /evidence=ECO:0000250	192..199
		Reprolysin	226..437	CDD:279729
		ZnMc_ADAMTS_like	226..434	CDD:239801
		TSP1	526..578	CDD:214559	21/51 (41%)
		ADAM_spacer1	683..794	CDD:283607	2/110 (2%)
		Spacer	683..794		2/110 (2%)
		TSP1	808..863	CDD:214559	17/55 (31%)
		TSP1	927..977	CDD:214559	19/53 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1009..1034		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1073..1127		7/53 (13%)
		MISS	1083..1334	CDD:292450	67/397 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1140..1237		27/155 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1283..1304		9/54 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1317..1384		28/189 (15%)
		TSP1	1437..1492	CDD:214559	20/77 (26%)
		TSP1	1541..1600	CDD:214559	19/60 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810