DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and Adamts13

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_006233941.3	Gene:	Adamts13 / 102554393	RGDID:	1311594	Length:	1482	Species:	Rattus norvegicus

Alignment Length:	900	Identity:	209/900 - (23%)
Similarity:	307/900 - (34%)	Gaps:	323/900 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP------GSCRGESTRYRICNMQPCPEQQ-DFRSSQ 133
            |.||||...|.|||:|.||::.:.|.|.:|      .:|.||..:.::||.|.|.:.| :|.|.|
  Rat   447 GHWSSWGPHSPCSRSCGGGVITRRRWCNNPRPAFGGRACVGEDLQAKMCNTQACEKTQLEFMSEQ 511

  Fly   134 CSAYNDVPY-----DGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQS 193
            |:..:..|.     ..:.|.|.....|.:...| ||    |:...:.                :|
  Rat   512 CAQTDRHPLQLSQGSASFYHWDAAVQYSQGDTL-CR----HMCWAVG----------------ES 555

  Fly   194 VIVQLSARVQDGTRC------RSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCS-- 250
            .||.......|||||      ..|::.:|:.|.|:..|||.|:.|.:..|.|.|||||.::|:
  Rat   556 FIVSRGDSFLDGTRCVPNGPREDGTVSLCLLGSCRTFGCDGKMDSQQVWDACQVCGGDNSTCTSQ 620

  Fly   251 ------------------------------QPLFN------------------------------ 255
                                          :|||.
  Rat   621 NGSFTAGRAREYVTFLIVTPNMTSAHVINHRPLFTHLAVRIQDHYIVSGKSSMSPNVTYPSLLED 685

  Fly   256 ----------------------------------------------------------------W 256
                                                                            |
  Rat   686 YRVEYRVTLTEDQLPRLEEIHIRGPVRDDIEIQVYRRYGGEYGGLTHPDITFTYFQRKQQAAWVW 750

  Fly   257 EMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWS 321
             .|....|||:||:|.:.....|:::..|..|.:..|..:.:|.|..|.|.:..|||.|:|||:.
  Rat   751 -AAKRGPCSVSCGAGLRWVTYSCQDQAQNKWVRNAQCQGSPQPPAWQEPCVSAPCPPHWVADDFG 814

  Fly   322 TCSRLCGHGYRERMVVCAEESNGIKTRVADIMCR--TPKPPTQ-ETCIIEECP-HWEVEDWTGC- 381
            .||..||.|.|||.:.|.|..||....:....||  ..:|..: |.|..:.|| .|||.|.:.|
  Rat   815 PCSVSCGGGLRERSLRCVEAHNGFLKTLPPAPCRAVAQQPAGEVENCNSQPCPTGWEVSDPSPCV 879

  Fly   382 SVSCGQGIQMRGVEC-----KSTDGSLSAKC-----DPLTKPGSMQQCSTGIHCGGSLNKVGGTI 436
            |.:|..|::.....|     .|...:::..|     .|:.:|.....||.|
  Rat   880 SSACEPGLESGSGTCVPRVGDSEKPAMAGPCRPDDMSPVPEPCVRTTCSPG-------------- 930

  Fly   437 IVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQS 501
                                           ...||.:..|::         |..|:
  Rat   931 -------------------------------SGPVDTMSLGEE---------ASSPV-------- 947

  Fly   502 RLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSP----CSVTCGEGIRRRT 562
                                    ..|:..|:.         ::.|:|    ||::||:|::...
  Rat   948 ------------------------GSGKPSSQA---------EHVWTPLVGLCSISCGKGLKELY 979

  Fly   563 YNCKIFLEYSRTVATVNDSLCE-GKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKT 626
            :.|.    .|.....|.:.||. ..||....|.|...||                      |.:
  Rat   980 FLCM----DSVLKMPVQEELCGLASKPPSRWEVCRARPC----------------------PAR- 1017

  Fly   627 YVWREQGYTSCSASCLGGVEELIINCVREDNGRVVS-PF-LCSPETKPEARVRTCNDRPCPPRWN 689
              |..:....|..:|.||...|.|:||:.|:||.|| |. .|.|..:| .....|:..|||.||.
  Rat  1018 --WETRVLAPCPVTCGGGRVPLAIHCVQLDHGRPVSVPHSKCWPAPRP-GSFEDCSPEPCPARWK 1079

  Fly   690 YSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQ--PPPADRQYCNVLDCPVRWEV 752
            .....|||.|||:|..|:.|.|: ::.:|.||.  |..:.|..  .|||... |.:.||..||.:
  Rat  1080 VLPLGPCSASCGLGTATQMVACV-QLDQGHDNE--VDETFCKALVRPPASVP-CLIADCAYRWHI 1140

  Fly   753 GEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPS-AKPADKKPCNVKPC 806
            ..|::||.:||.|.:.|...|   :..:.::..|.:.|.. .||...:.|...||
  Rat  1141 STWTECSVSCGDGIQRRHGTC---LGPQAQVPVPANFCQHLPKPVTVRGCWAGPC 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	20/51 (39%)
		TSP1	546..600	CDD:214559	16/58 (28%)
		TSP1	750..807	CDD:214559	15/57 (26%)
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
Adamts13	XP_006233941.3	ZnMc_ADAMTS_like	139..345	CDD:239801
		ADAM_CR_2	363..433	CDD:407643
		TSP1	449..501	CDD:214559	20/51 (39%)
		TSP1_ADAMTS	755..804	CDD:408800	14/48 (29%)
		TSP1_ADAMTS	808..866	CDD:408800	21/57 (37%)
		TSP1_ADAMTS	960..1014	CDD:408800	16/57 (28%)
		TSP1_ADAMTS	1018..1074	CDD:408800	19/56 (34%)
		TSP1_ADAMTS	1078..1134	CDD:408800	20/59 (34%)
		TSP1_ADAMTS	1138..1192	CDD:408800	14/56 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910