DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and adamts3

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_021331662.1	Gene:	adamts3 / 102467218	ZFINID:	ZDB-GENE-110223-1	Length:	1192	Species:	Danio rerio

Alignment Length:	983	Identity:	201/983 - (20%)
Similarity:	316/983 - (32%)	Gaps:	389/983 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP------GSCRGESTRYRICNMQPCPEQ-QDFRSSQ 133
            |.|.:||.:.:|||:|..|:..:.|:|.:|      ..|.|.:..|::||...||:. :|||:.|
Zfish   544 GAWGAWSKYGSCSRSCGMGVRFRTRQCNNPVPSNGGQDCPGVNYEYQLCNTDDCPKHFEDFRAQQ 608

  Fly   134 CSAYND-VPYDGTLYKWTP--HYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVI 195
            |...|. ..|....:.|.|  |.|..:.|.|.|:          |:||||              :
Zfish   609 CQLRNSHFEYQNAKHHWLPYEHPDANKRCHLYCQ----------SKETGD--------------V 649

  Fly   196 VQLSARVQDGTRCR-SGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFNWEMA 259
            ..:...|.|||||. .....:|::|:|.:||||.:|||.|..|.|||||||.:.|......:...
Zfish   650 AYMKQLVHDGTRCSYKDPYSICVRGECVKVGCDREIGSNKVEDKCGVCGGDNSHCRTVKGTFTRV 714

  Fly   260 PMSQCSVTCGSGY--KMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWST 322
            | .:...|.|:..  |.:|.:..|.  .||..:.:
Zfish   715 P-KKAGKTRGAFLLPKGARNVYLNE--TADSRNVM------------------------------ 746

  Fly   323 CSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEVEDWTGCSVSCGQ 387
                   ||.:..::                     ||.....||:|  |
Zfish   747 -------GYLKMFLI---------------------PPGARHVIIQE--H--------------- 766

  Fly   388 GIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQL 452
                     :::...|:.|                       |:..|..::
Zfish   767 ---------EASPQILAIK-----------------------NQATGHYVL-------------- 785

  Fly   453 DSSDADEDNEDENDEGDDVDD---LESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTM 514
                        |.:|:|...   :|.|.:.|             |.          ..::..|:
Zfish   786 ------------NGKGEDARSRRFIEMGVEWD-------------YL----------VEEDVETL 815

  Fly   515 HLMNGNSNNNFNRGEDESEGPSLDPTYI----KDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTV 575
            |                ::||..|...:    ||||            .|.|...|..:.
Zfish   816 H----------------TDGPLNDAIVVLIIPKDNE------------TRSTLMYKYIIH----- 847

  Fly   576 ATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSAS 640
                                            :|..|.::..| :.|  .||.|..:.::.||..
Zfish   848 --------------------------------EDSVPLNNNNV-IQE--DTYEWALKSWSQCSRP 877

  Fly   641 CLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPC-PPRWNYSDYTPCSKSCG-IG 703
            |.||.:.....|.::.:.::|....|....||:...|.||.:.| .|:|...::..|:|:|| :|
Zfish   878 CAGGFQYTKYGCRKKGDNKMVHRGYCDVNKKPKPIRRMCNLQDCTQPQWITEEWEHCTKTCGSLG 942

  Fly   704 IKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKD 768
            .:.|.|:|:..:..|.:.:  :.:..|....|..|:.||.:.||.:|..|.||:||.:||.|...
Zfish   943 YQIRTVRCVQFLHEGTNRS--IHSKYCNGEKPEMRRACNRVACPAQWRTGAWSECSVSCGEGVSR 1005

  Fly   769 RKVECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCPPEDPKPVIQINNSTHIQHDPKKTKIT 833
            |.|.|           |....|...||..:|||..:||                  ||.
Zfish  1006 RLVTC-----------RIGDQCTGEKPESQKPCRPRPC------------------HDE------ 1035

  Fly   834 LKVGGAGLVFFGTQVKIK-CPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITFRDAGV 897
             ..||...:|...:|..: |.:..||:.                          ..:...|.:|.
Zfish  1036 -PCGGDKSIFCQMEVLARYCSIPGYNKL--------------------------CCESCSRRSGT 1073

  Fly   898 YS--CHAGLSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSADMKSADGTGTSTAVG 960
            ::  .|                       |..|||..:|..|.::.|   :..||...|:...
Zfish  1074 FAPLLH-----------------------EAAETEEELRFGSASQLL---ETLSAAANGSLKV-- 1110

  Fly   961 PNSHVNGSAQQHGSRRRQ-----QQSERLQNGRERSR-RPKS--------------DGVQHADSS 1005
            |..|..||..| |...:|     .:....:|.:.:.| :|.:              |||:.|...
Zfish  1111 PQQHQRGSTSQ-GQFSKQAATPPPRKHNTENSKTQKRLKPSTRNLPALSIHSSWSEDGVKDAPMQ 1174

  Fly  1006 IMEDDLSQ 1013
            :.....||
Zfish  1175 LESFQESQ 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	16/51 (31%)
		TSP1	546..600	CDD:214559	4/53 (8%)
		TSP1	750..807	CDD:214559	20/56 (36%)
		IGc2	845..902	CDD:197706	6/59 (10%)
		PLAC	1355..1384	CDD:285849
adamts3	XP_021331662.1	Pep_M12B_propep	42..197	CDD:307618
		ZnMc_ADAMTS_like	248..449	CDD:239801
		TSP1	546..598	CDD:214559	16/51 (31%)
		ADAM_spacer1	705..847	CDD:310520	39/328 (12%)
		TSP1	926..984	CDD:214559	15/59 (25%)
		TSP1	987..1033	CDD:214559	21/74 (28%)
		PLAC	1040..1068	CDD:312271	5/53 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900