Protein Alignment nolo and adamts3

DIOPT Version :10

• Sequence 1: NP_001036374.1
• Gene: nolo / 35424
• FlyBaseID: FBgn0051619
• Length: 1394
• Species: Drosophila melanogaster
• Sequence 2: XP_073805801.1
• Gene: adamts3 / 102467218
• ZFINID: ZDB-GENE-110223-1
• Length: 1211
• Species: Danio rerio
• Alignment Length: 982
• Identity: 202/982 - (20%)
• Similarity: 323/982 - (32%)
• Gaps: 368/982 - (37%)

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSP------GSCRGESTRYRICNMQPCPEQ-QDFRSSQ 133
            |.|.:||.:.:|||:|..|:..:.|:|.:|      ..|.|.:..|::||...||:. :|||:.|
Zfish   544 GAWGAWSKYGSCSRSCGMGVRFRTRQCNNPVPSNGGQDCPGVNYEYQLCNTDDCPKHFEDFRAQQ 608

  Fly   134 CSAYND-VPYDGTLYKWTP--HYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVI 195
            |...|. ..|....:.|.|  |.|..:.|.|.|:          |:||||              :
Zfish   609 CQLRNSHFEYQNAKHHWLPYEHPDANKRCHLYCQ----------SKETGD--------------V 649

  Fly   196 VQLSARVQDGTRCR-SGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFNWEMA 259
            ..:...|.|||||. .....:|::|:|.:||||.:|||.|..|.|||||||.:.|......:...
Zfish   650 AYMKQLVHDGTRCSYKDPYSICVRGECVKVGCDREIGSNKVEDKCGVCGGDNSHCRTVKGTFTRV 714

  Fly   260 PMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCS 324
            |..       :|.|:::   |::.....:::|:                           |.|..
Zfish   715 PKK-------AGKKLTK---RSQKEIHVLENTI---------------------------WKTRG 742

  Fly   325 R-LCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEVEDWTGCSVSCGQG 388
            . |...|.|...:....:|..:...:...:.    ||.....||:|  |
Zfish   743 AFLLPKGARNVYLNETADSRNVMGYLKMFLI----PPGARHVIIQE--H---------------- 785

  Fly   389 IQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLD 453
                    :::...|:.|                       |:..|..::
Zfish   786 --------EASPQILAIK-----------------------NQATGHYVL--------------- 804

  Fly   454 SSDADEDNEDENDEGDDVDD---LESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMH 515
                       |.:|:|...   :|.|.:.|             |.          ..::..|:|
Zfish   805 -----------NGKGEDARSRRFIEMGVEWD-------------YL----------VEEDVETLH 835

  Fly   516 LMNGNSNNNFNRGEDESEGPSLDPTYI----KDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVA 576
                            ::||..|...:    ||||            .|.|...|..:.
Zfish   836 ----------------TDGPLNDAIVVLIIPKDNE------------TRSTLMYKYIIH------ 866

  Fly   577 TVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASC 641
                                           :|..|.::..| :.|  .||.|..:.::.||..|
Zfish   867 -------------------------------EDSVPLNNNNV-IQE--DTYEWALKSWSQCSRPC 897

  Fly   642 LGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPC-PPRWNYSDYTPCSKSCG-IGI 704
            .||.:.....|.::.:.::|....|....||:...|.||.:.| .|:|...::..|:|:|| :|.
Zfish   898 AGGFQYTKYGCRKKGDNKMVHRGYCDVNKKPKPIRRMCNLQDCTQPQWITEEWEHCTKTCGSLGY 962

  Fly   705 KTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDR 769
            :.|.|:|:..:..|.:.:  :.:..|....|..|:.||.:.||.:|..|.||:||.:||.|...|
Zfish   963 QIRTVRCVQFLHEGTNRS--IHSKYCNGEKPEMRRACNRVACPAQWRTGAWSECSVSCGEGVSRR 1025

  Fly   770 KVECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCPPEDPKPVIQINNSTHIQHDPKKTKITL 834
            .|.|           |....|...||..:|||..:||                  ||.
Zfish  1026 LVTC-----------RIGDQCTGEKPESQKPCRPRPC------------------HDE------- 1054

  Fly   835 KVGGAGLVFFGTQVKIK-CPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITFRDAGVY 898
            ..||...:|...:|..: |.:..||:.                          ..:...|.:|.:
Zfish  1055 PCGGDKSIFCQMEVLARYCSIPGYNKL--------------------------CCESCSRRSGTF 1093

  Fly   899 S--CHAGLSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSADMKSADGTGTSTAVGP 961
            :  .|                       |..|||..:|..|.::.|   :..||...|:...  |
Zfish  1094 APLLH-----------------------EAAETEEELRFGSASQLL---ETLSAAANGSLKV--P 1130

  Fly   962 NSHVNGSAQQHGSRRRQ-----QQSERLQNGRERSR-RPKS--------------DGVQHADSSI 1006
            ..|..||..| |...:|     .:....:|.:.:.| :|.:              |||:.|...:
Zfish  1131 QQHQRGSTSQ-GQFSKQAATPPPRKHNTENSKTQKRLKPSARNLPALSIHSSWSEDGVKDAPMQL 1194

  Fly  1007 MEDDLSQ 1013
            .....||
Zfish  1195 ESFQESQ 1201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	16/51 (31%)
		TSP1_ADAMTS	256..311	CDD:465950	5/54 (9%)
		TSP1_ADAMTS	315..370	CDD:465950	10/55 (18%)
		TSP1_ADAMTS	373..420	CDD:465950	2/46 (4%)
		TSP1	546..600	CDD:214559	4/53 (8%)
		TSP1_ADAMTS	629..684	CDD:465950	14/54 (26%)
		TSP1_ADAMTS	688..746	CDD:465950	15/58 (26%)
		TSP1_ADAMTS	750..806	CDD:465950	19/55 (35%)
		Ig	845..914	CDD:472250	7/71 (10%)
		Ig strand B	848..852	CDD:409353	1/4 (25%)
		Ig strand C	861..865	CDD:409353	0/3 (0%)
		Ig strand E	883..887	CDD:409353	0/3 (0%)
		Ig strand F	897..902	CDD:409353	0/6 (0%)
		TSP1_ADAMTS	1157..1227	CDD:465950
		TSP1_ADAMTS	1289..1343	CDD:465950
		PLAC	1355..1384	CDD:462560
adamts3	XP_073805801.1	None