DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and adamts17

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_021333385.1	Gene:	adamts17 / 101884120	ZFINID:	ZDB-GENE-121030-7	Length:	1134	Species:	Danio rerio

Alignment Length:	820	Identity:	203/820 - (24%)
Similarity:	285/820 - (34%)	Gaps:	288/820 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPCPE-QQDFRSSQ 133
            |.||.||.||.|||||..|...:.|:|.:|..      |:..|..:::|...||.: ...||..|
Zfish   534 GDWSPWSTWSMCSRTCGTGARFRQRKCDNPPPGPGGKYCQKASVEHKVCEGPPCTKGLPTFRDQQ 598

  Fly   134 CSAYNDVPYDGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQL 198
            |.:: :.........||...|..:||||.|              |..|:        :..|:|
Zfish   599 CQSH-ERQASKKSQMWTAVIDDEKPCALYC--------------TPVGS--------DSPVLV-- 638

  Fly   199 SARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCS--QPLFNWE--MA 259
            :.||.|||.|.....|:|:.||||::|||..|||:.|.|.||||.|||.||.  :..||..  |.
Zfish   639 AERVLDGTPCGPYESDLCVNGKCQKIGCDGIIGSSAKEDRCGVCNGDGKSCRIVKGDFNHSKGMV 703

  Fly   260 PMSQCS--VTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHS------CPPRWI 316
            |.|.|.  .||    .||:|....:..:..::..:..|..|....||...:||      ...|.|
Zfish   704 PHSLCKKVSTC----VMSKPRAVLKCFSCYIEAAVIPVGARRIKVVEDKPSHSFLALKDSSKRSI 764

  Fly   317 ADDW-----------STCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEEC 370
            .:||           .|..|....|..|:|                    :.|.||:...
Zfish   765 NNDWKIELPGEFELAGTTVRYVRRGLWEKM--------------------SAKGPTKTPL----- 804

  Fly   371 PHWEV---EDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKV 432
             |..|   .|.|                                         .|||...::
Zfish   805 -HLMVLLFHDQT-----------------------------------------YGIHYEYTV--- 824

  Fly   433 GGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAH 497
                      :||...|   :|||..:
Zfish   825 ----------ALNHSQE---NSSDLVK-------------------------------------- 838

  Fly   498 RTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRT 562
                        ||..|:|...:|                         |..|||.||.|.||..
Zfish   839 ------------EPEHMYLWTHSS-------------------------WEDCSVHCGGGERRTV 866

  Fly   563 YNCKIFLEYSRTVATVNDSLCE-GKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKT 626
            .:|...:  ::|:..||||.|: ..||..::.:|...||.
Zfish   867 VSCMRII--NKTMTPVNDSSCQVENKPSPQIRQCNIHPCQ------------------------- 904

  Fly   627 YVWREQGYTSCSASCLGGVEELIINCVRE-DNGRVV-SPFLCSPETKPEARVRTCNDRPCPPRWN 689
            |.|....:|.||.:|..|:::..:.|:.: .||..: :..|....:|| |.|:.|..|.|...|.
Zfish   905 YRWVTGDWTQCSLTCGKGLQQREVGCIYQLQNGTYIPTRDLYCLSSKP-ASVQHCEGRHCLTVWE 968

  Fly   690 YSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMC-PQPPPADRQYCNVLDCPVRWEVG 753
            .|:::.||..||.|.:.|.|.|.:            |:.:| |...||:.:.|........|:.|
Zfish   969 ASEWSQCSSECGHGSRRRTVTCTN------------PHGLCDPVSRPAEVEACEDHSKCYEWKTG 1021

  Fly   754 EWSKCSHTCGYGFKDRKVECKQIMAQEHKIE-RPESMCPSA-KPADKKPCNVKPCPPEDPKPVIQ 816
            ||||||.:||.|.:.|.|:|.      |::. |..|.||:. |||..:.|:...|....     .
Zfish  1022 EWSKCSSSCGRGLQSRVVQCM------HRVSGRHGSDCPAVLKPATYRQCHQSTCNARG-----N 1075

  Fly   817 INNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIKCPVKR 856
            ||..|    .|:...:|.|.       .|.|..:.|.|.|
Zfish  1076 INTIT----SPRLAALTYKC-------VGDQWAVYCKVIR 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	19/51 (37%)
		TSP1	546..600	CDD:214559	19/54 (35%)
		TSP1	750..807	CDD:214559	23/58 (40%)
		IGc2	845..902	CDD:197706	5/12 (42%)
		PLAC	1355..1384	CDD:285849
adamts17	XP_021333385.1	Pep_M12B_propep	33..170	CDD:307618
		ZnMc_ADAMTS_like	223..439	CDD:239801
		TSP1	536..587	CDD:214559	18/50 (36%)
		ADAM_spacer1	729..824	CDD:310520	25/161 (16%)
		TSP1	907..>931	CDD:214559	6/23 (26%)
		TSP1	966..1013	CDD:214559	16/58 (28%)
		TSP1	1018..1070	CDD:214559	23/57 (40%)
		PLAC	1099..1123	CDD:312271	3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10929
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810