DRSC/TRiP Functional Genomics Resources

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Protein Alignment nolo and thsd7b

DIOPT Version :10

Sequence 1:NP_001036374.1 Gene:nolo / 35424 FlyBaseID:FBgn0051619 Length:1394 Species:Drosophila melanogaster
Sequence 2:XP_002933997.3 Gene:thsd7b / 100498151 XenbaseID:XB-GENE-6043658 Length:1604 Species:Xenopus tropicalis


Alignment Length:1411 Identity:296/1411 - (20%)
Similarity:463/1411 - (32%) Gaps:431/1411 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 FNWEMAPMSQCSVTCGSGYKMSRPI-CRNR---LTNADVDDTLCSVTNRPEAS---VEQCNTHSC 311
            |.|:..|..:|...||...:.||.: |.:.   :|:    ::.|...::||:.   .:.|:.||.
 Frog    43 FVWKSGPWGRCIGDCGPSAQESRSVWCVHEEGWITH----NSNCKTKDKPESQRSCFKTCDWHSE 103

  Fly   312 PPRWIADDWSTCSRL---------------CGHGYRERMVVCAEESNGIKTRVADIMCR--TPKP 359
            ...|...:|.||..:               ..||.:.|.|.|.::.|  ::.|...:|.  ||:|
 Frog   104 LFHWEVTEWQTCVLVPYPHQEKARPLECVTAQHGLQHRRVDCVQKIN--RSVVLGEICEHFTPRP 166

  Fly   360 PTQETCII---EECPHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCST 421
            ||::.|::   ::|...:...|:.|..||.:.:|.|.....|......::|..||:   .:.|..
 Frog   167 PTEQACLVPCPQDCVVSDFSHWSTCGHSCEKRLQHRTRAVISPPLYGGSECPNLTE---SRTCEF 228

  Fly   422 GIHCGGSLNKVGGTIIVG--------SSRSLNERSERQLD-SSDADEDNEDEND-----EGDDVD 472
            ...|.....:...::.||        ..:.:|......:| |||..|.|..:.:     :.....
 Frog   229 HSFCSFGNEEYTYSLKVGPWSECRLPHLKEMNVSGRTMVDFSSDLAETNRYKKEMYKVRQRHSAW 293

  Fly   473 DLESGQDT-------DDGE----GLSYADQPLLY------------------------------- 495
            |:|.|..|       .||.    .:...|.||.:                               
 Frog   294 DIEIGYQTRHVRCTRSDGRNALLSICTQDMPLHFQSCIIPKDCEVTEWGQWGQCSKTCRSGDMAP 358

  Fly   496 AHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDES-----EGPSLDPTYI-KDNEWSPCSVT- 553
            ..|::||         ...|:..|.........|.|:     |...|.|... |.:||..|.:: 
 Frog   359 GFRSRSR---------EVKHIAIGGGRPCPEPKEKEACIMGGEHLPLCPGIAWKTSEWMECQLSF 414

  Fly   554 -------------CGEGIRRRTYNC-KIFLE---YSRTVATVNDSLCEGKKPHDEVER------- 594
                         ||.|.:.|...| :.|:|   .......|.:..|.|..|  .|.:       
 Frog   415 DHQDSHPSSPNPACGGGTQSRKVFCAQYFIETETLKEVYRPVEERFCLGPMP--PVSQLCNIPCS 477

  Fly   595 -------------CVEDPCMLPS--HGFDDQFPRDSIKVGVSEPGKT---------------YVW 629
                         |..:.|:.|.  .||..:  :.:|.|....|..|               |.|
 Frog   478 SDCLLTPWSAWGPCTHENCLDPQGRKGFRSR--KRNIIVEPMGPEGTCSHLVESIPCDDPTCYNW 540

  Fly   630 REQGYTSC---SASCLGGVEELIINCVREDNGRVVSPFLC--SPETKPEARVRTCNDRPCP---- 685
            ...|...|   :..|..|..:|..:|..:| |::||..||  ||..:...:|      ||.    
 Frog   541 VISGEPYCVPENKECGHGKYQLNTSCENQD-GQIVSDDLCLDSPPVQLVCKV------PCSQDCV 598

  Fly   686 -PRWNYSDYTPCSKSCGI----GIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQY--CNV 743
             ..|  ||::|||.||..    |.::|....:.....||        ..|| |..|..:|  ||.
 Frog   599 ISEW--SDWSPCSHSCSSKNSEGKQSRTRSILANPGEGG--------KACP-PSQALYEYRLCNE 652

  Fly   744 LDCPV-RWEVGEWSKCS-----------------HTCGYGFKDRKVECKQIMAQEHKIERPESMC 790
            ..|.. .||...|..||                 :.||.|.:.|||.|.:........:|    |
 Frog   653 HPCSAFYWESTPWGTCSADPLLTALNTSVSWKEDNACGAGIQSRKVFCVKSSVGHVTSKR----C 713

  Fly   791 PSA-KPADKKPCNVK--------------PCPPEDPKPVIQINNSTHIQHDPKKTKITLKVGGAG 840
            |.| :|...:||.:.              |||..     ..:.|:|.::....:|.|   :..| 
 Frog   714 PEATRPETIRPCLLSCKRDCKVTLFSEWTPCPTS-----CLLGNATSVKQSRYRTVI---LDAA- 769

  Fly   841 LVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITFRD---AGVYSCHA 902
               :|.|   :||...|...:.    :..|:..:..:|.::.....::..:.|.   .|..||..
 Frog   770 ---YGGQ---ECPDTLYEEREC----EDLPICLNYSWKTNQWSPCVLVPESVRQGIVGGSESCGT 824

  Fly   903 GLSSAEIS-IEVKAKPGQQIEELE--------QQETERLVREKSGTEALTSADMKSADGTGTSTA 958
            ||.|.|:: |....:|......|:        .||.....::.......:.....|||.|.:.| 
 Frog   825 GLQSTEVTCISDDGRPVDMTSCLKWAGLMPPLVQECHLPCKDDCTFTPWSKFTPCSADCTSSRT- 888

  Fly   959 VGPNSHVNGSAQQHGSRRRQQQSERLQNGRERS---RRPKSDGVQHAD-SSIMEDDLSQLVQSED 1019
                                         |:||   |..|.|..|:|: ..:.|.::...|    
 Frog   889 -----------------------------RKRSLTGRSKKRDKCQNAEVYPLTESEMCPCV---- 920

  Fly  1020 RIPQPASASSGGSRTRTLLAMPY---FQALLSNLQLLWPLQRFKDSRGQHLLQGEALKFG----I 1077
                            |.|..||   ...::...:...||...|...|:..  |:..:|.    .
 Frog   921 ----------------TFLPHPYGNWSDCIIPRAEREQPLGMSKAGDGRQC--GDGTRFRASACY 967

  Fly  1078 DLSGKDFDQ---------DESERVPAE---QLPPEVLHSPSDPE------------YHEPSKSG- 1117
            |..|:..|.         :||..:|..   :|......||....            ..:|...| 
 Frog   968 DSGGRIVDPSLCGSSGYIEESCVIPCPFDCKLSDWSAWSPCSSSCGTGVKIRSKWLKEKPYNGGR 1032

  Fly  1118 --PEADVPHVPPHMPHARWETGAAASTTAVPSLPNDGFVYRWMLGEWSQC----SQECGAAGSGL 1176
              |:.|:.:             .|....|||.. |:...|.|:...||.|    .:...|.|.|:
 Frog  1033 PCPKLDIKN-------------QAQVYEAVPCY-NECSEYSWVAEPWSACKLNTEERPAACGHGI 1083

  Fly  1177 QRRTVSCQRAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQSCGNEACP------QWSKGDW 1235
            |...|.|...::        |.|...|::|.|  .|.:.....|.| :..||      .|  |.|
 Frog  1084 QIGKVRCVNVSR--------DGEGAPVNDSYC--QGSQSGPTVQEC-SLPCPGECVMSNW--GHW 1135

  Fly  1236 TPCQRSHCHGRNTAMQRREVTCRYP-NGTEGSICDEYERPAMRQECYNERCEGVWRVEPWSEC-- 1297
            :.|.:...   .|...||....|.| ||.|.....:.|...:...|::..    :.:..||.|  
 Frog  1136 SDCTKCDI---GTMRTRRRFPLRIPVNGHECPEGTQTEPCRLNSNCFHYH----YNITEWSTCQL 1193

  Fly  1298 --NAPCGRKGIKYRILQCVWYGSRRPAGNVC----KHQPRPAVMKVCKSPACQAQLS-----SSP 1351
              :|.|| :|:|.|:|.|:....:....::|    :.:|.|..::.....|...|||     |..
 Frog  1194 SGDAECG-EGLKTRLLDCIRSDGQSVQTSLCEQMNREKPFPMSIRCLVECAIACQLSEWSDWSQC 1257

  Fly  1352 AQLCRDSSRYCRNAR----AMGLCR-----LHRYKLKCCGSCEQQP 1388
            :|.|....:..|:.|    |.|..|     |.:||     ||...|
 Frog  1258 SQTCGVGGQMVRSRRLLLQAQGEGRPCPKQLSQYK-----SCPIYP 1298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
noloNP_001036374.1 TSP1 78..124 CDD:214559
TSP1_ADAMTS 256..311 CDD:465950 14/61 (23%)
TSP1_ADAMTS 315..370 CDD:465950 18/74 (24%)
TSP1_ADAMTS 373..420 CDD:465950 10/46 (22%)
TSP1 546..600 CDD:214559 16/91 (18%)
TSP1_ADAMTS 629..684 CDD:465950 16/59 (27%)
TSP1_ADAMTS 688..746 CDD:465950 19/63 (30%)
TSP1_ADAMTS 750..806 CDD:465950 19/87 (22%)
Ig 845..914 CDD:472250 16/72 (22%)
Ig strand B 848..852 CDD:409353 0/3 (0%)
Ig strand C 861..865 CDD:409353 0/3 (0%)
Ig strand E 883..887 CDD:409353 0/3 (0%)
Ig strand F 897..902 CDD:409353 2/4 (50%)
TSP1_ADAMTS 1157..1227 CDD:465950 18/73 (25%)
TSP1_ADAMTS 1289..1343 CDD:465950 14/61 (23%)
PLAC 1355..1384 CDD:462560 9/37 (24%)
thsd7bXP_002933997.3 TSP1_ADAMTS 45..95 CDD:465950 12/53 (23%)
TSP1_ADAMTS <137..175 CDD:465950 13/39 (33%)
TSP1_spondin 180..226 CDD:465948 11/48 (23%)
TSP1_spondin 336..387 CDD:465948 7/59 (12%)
TSP1_spondin 480..537 CDD:480609 9/58 (16%)
TSP1_spondin 597..655 CDD:465948 19/68 (28%)
TSP1_ADAMTS 660..727 CDD:465950 19/70 (27%)
TSP1_spondin 733..789 CDD:480609 13/74 (18%)
TSP1_spondin 997..>1037 CDD:465948 6/39 (15%)
TSP1_ADAMTS 1060..1122 CDD:465950 18/72 (25%)
TSP1_spondin 1127..1176 CDD:480609 13/53 (25%)
TSP1_spondin 1246..1299 CDD:465948 17/58 (29%)
TSP1_spondin 1369..1428 CDD:465948
Blue background indicates that the domain is not in the aligned region.

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