DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and adamts16

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_031760055.1	Gene:	adamts16 / 100498052	XenbaseID:	XB-GENE-986244	Length:	1234	Species:	Xenopus tropicalis

Alignment Length:	853	Identity:	203/853 - (23%)
Similarity:	286/853 - (33%)	Gaps:	335/853 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LCLLD-----TQAAW---------AKKLNASQAF---DDTWNTASDLENELEQQKRSKVQSAGGG 68
            ||:||     .:|.|         .|.:.|::..   .|.|.......|..|:
Frog   539 LCMLDFKKDICKALWCHRVGRKCETKFMPAAEGTICGHDMWCRRGQCVNYGEE------------ 591

  Fly    69 GGAGGGPGQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPCPEQQ 127
             |.....||||.||.||.|||||.||:.::.|:|.:|..      |.|.|...::||.|.||:..
Frog   592 -GPKATDGQWSEWSTWSPCSRTCGGGVSYKERQCTNPRPSHGGKFCEGSSRVNKLCNNQSCPKNN 655

  Fly   128 -DFRSSQCSAYNDVPYDGTLYKWTPHYDYVEP---CALTCRGHPAHLVEDISRETGDGNAEEAEH 188
             |||:.||:.||..|:.|..|.|.| |..||.   |.|.|                     .||.
Frog   656 IDFRAQQCAEYNSKPFRGWYYNWKP-YTRVEEHEYCKLYC---------------------IAEG 698

  Fly   189 YDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC---- 249
            :|   ....||.:|:|||.|...|.::||.|.|:.||||..:||....|.||||.||.::|
Frog   699 FD---FFFSLSNKVKDGTTCSEYSNNVCIDGICETVGCDHLLGSNAVQDICGVCKGDNSTCKVYR 760

  Fly   250 ----------------------------------------------------------------- 249

Frog   761 SHYTKQHYSNQYYSIVTIPAGARSIRINEMNISTSYISIRNNEKKYYLNGHWTVDWPGQYKFAGS 825

  Fly   250 ----SQPLFN----------------------------WE--MAP------------------MS 262
                .:|..|                            ||  ||.                  .|
Frog   826 VFHYKRPFNNPESLSTAGPINETLVVEIFLQGKNPGIAWEYSMAKSVSVKKPTIKHNYTWAIIKS 890

  Fly   263 QCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLC 327
            :|||:||.|:..::..|...: ...|:.:.||..|||......||...|.|||...:|:.||:.|
Frog   891 ECSVSCGGGHMNTKEGCYKDM-RVQVNTSFCSAKNRPVTGPLPCNPQPCLPRWSVGNWTECSQTC 954

  Fly   328 GHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEEC-PHWEVEDWTGCSVSCGQGIQM 391
            |.|.:.|.|.|.:..:.....||:.:|..|.|..::.|..:.| |.|.|..|:.||.:||:|.:.
Frog   955 GSGEQFRQVQCKQRKHFKLEIVANKLCTMPPPLHRQICNTQSCPPAWSVGTWSECSRTCGKGWRK 1019

  Fly   392 RGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSD 456
            |.|.||||:.||.|:..|   .|:   |:|..
Frog  1020 RTVVCKSTNPSLHAQVLP---DGA---CTTEF--------------------------------- 1045

  Fly   457 ADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNS 521
                                              :|::.......|.|     :|:.:..:..|
Frog  1046 ----------------------------------KPVIQEICIVKRCN-----KPKKLQWIISN- 1070

  Fly   522 NNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEG- 585
                                     ||.||.|||.|.:||...| |....|..........|..
Frog  1071 -------------------------WSECSTTCGSGSQRRILRC-IEKYVSGKYREFGPKKCSHL 1109

  Fly   586 KKPHDEVER-CVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELI 649
            :||:.|:|| |::..|:...:          ..|...:.|.   |....::.|:.||.||::..|
Frog  1110 QKPNMELERTCLQAECLKYRY----------YSVVNQQRGS---WYSSEWSQCTVSCGGGMQVRI 1161

  Fly   650 INCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCPP-----------RW----------NYSDY 693
            :.|:  .||:..:  .|.|..||::. :.||...||.           .|          |:..|
Frog  1162 VQCL--SNGKPAT--RCQPHQKPKSS-QACNTDFCPSEKKDNLCKDYFNWCYLVPQHGMCNHKFY 1221

  Fly   694 -TPCSKSC 700
             ..|.|||
Frog  1222 GKQCCKSC 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	22/51 (43%)
		TSP1	546..600	CDD:214559	20/55 (36%)
		TSP1	750..807	CDD:214559
		IGc2	845..902	CDD:197706
		PLAC	1355..1384	CDD:285849
adamts16	XP_031760055.1	TSP1	600..652	CDD:214559	22/51 (43%)
		ADAM_spacer1	757..868	CDD:368694	4/110 (4%)
		TSP1_ADAMTS	942..997	CDD:408800	16/54 (30%)
		TSP1_ADAMTS	1001..1058	CDD:408800	22/129 (17%)
		TSP1_ADAMTS	1066..1125	CDD:408800	21/85 (25%)
		TSP1_ADAMTS	1141..1191	CDD:408800	16/54 (30%)
		PLAC	1200..1230	CDD:400844	7/30 (23%)
		Pep_M12B_propep	80..204	CDD:396235
		ZnMc_ADAMTS_like	301..502	CDD:239801
		ADAM_CR_2	519..586	CDD:407643	10/46 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910