DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nolo and adamts20

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_002932868.3	Gene:	adamts20 / 100489781	XenbaseID:	XB-GENE-949936	Length:	1909	Species:	Xenopus tropicalis

Alignment Length:	1673	Identity:	334/1673 - (19%)
Similarity:	481/1673 - (28%)	Gaps:	739/1673 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVNMNW-TSPKIWAAL---FVTTL-------CLLDTQAA----WAKKL-----NASQAFDDTWN 45
            |:..:|: |||..|:..   ::|..       ||||....    ::.:|     |.::..:..:.
Frog   433 MAATLNYNTSPWTWSKCSQKYITEFLDTGYGECLLDKPNGRIYEFSNQLPGVIYNVNKQCELMFG 497

  Fly    46 TASDLENELEQQKRSKVQSAGG------------GGGAGGGP--------------------GQW 78
            |.|.:...::|.||....|..|            ..|:..||                    |:|
Frog   498 TGSQVCPYMKQCKRLWCTSTEGIQKGCRTQHMPLADGSDCGPHMYCRSGICVNKAMDTRPVDGEW 562

  Fly    79 SSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPCPE-QQDFRSSQCSA 136
            ..|..:|:|||.|.|||....|.|..|..      |.|...::|.||...||. ::|||..||::
Frog   563 GPWGSYSSCSRICGGGIKTITRDCNQPEPRNGGKYCVGRRMKFRSCNTDSCPRGRKDFRDEQCTS 627

  Fly   137 YNDVPYD-----GTLYKWTPHYDYV---EPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQS 193
            ::...::     |:: :|.|.|..:   :.|.|.||                        ....|
Frog   628 FDGKHFNINGLTGSV-RWIPKYSGILMKDRCKLFCR------------------------VSGTS 667

  Fly   194 VIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQ------- 251
            ...||..||.|||.|...|.|:|:||.|::.|||..:.|..|.|.|||||||.:||..
Frog   668 SYYQLKDRVIDGTSCGPESDDICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSCKTVAGTFNT 732

  Fly   252 ----------------------------------------------------------------- 251

Frog   733 AQYGYNTIIKIPTGATNIDVRQHSFSGYPEDDNYLALSDTKGNFVLNGNFVVSRFKREINIKGTT 797

  Fly   252 -------------------------------PLFN-------------------WE-MAPMSQCS 265
                                           .|||                   |: ..|...|:
Frog   798 FEYSGSDNAIERINCTDRLEEELILQVLCVGSLFNPDVRYTFNIPTEDKIAQFLWDPYGPWQNCN 862

  Fly   266 VTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHG 330
            ..| .|.:..:..|..|.....|.:..|....:||...|.|| :.|..||.....|.|:..||.|
Frog   863 KMC-QGVRERKVTCVRRSDRVVVSEQRCKHLPQPEKITETCN-NDCQLRWYVAGQSECTSQCGPG 925

  Fly   331 YRERMVVCAEES-NGIKTRVADIMCR-TPKPPTQETCIIEEC--PHWEVEDWTGCSVSCGQGIQM 391
            :|...:.|.:.| .|..|.|.|..|. ..||..:|.| ..:|  ..|...:|:.||:|||:|||.
Frog   926 HRTLDIRCIKYSTKGSSTPVDDKFCSGQSKPSNKEFC-HGDCFSSSWHYTEWSQCSLSCGRGIQT 989

  Fly   392 RGVECKSTDG-----------------SLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVG 439
            |...|.|..|                 |.|....|:.......:|:  :.||      .||....
Frog   990 REAFCMSNFGRRLSDRECIDQQKVIRQSCSEFSCPVWHTSEWSECA--VTCG------KGTKYRH 1046

  Fly   440 SSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLN 504
            .|..||                      |:.:|:          ...|.:.:||    ..||..:
Frog  1047 VSCQLN----------------------GEKLDE----------NYCSLSSKPL----SVQSCEH 1075

  Fly   505 QEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNC--KI 567
            :|.                     .....||           |:||:||||.|.:.|...|  ..
Frog  1076 EEC---------------------ASWKVGP-----------WAPCAVTCGHGFQMRRVTCVSGT 1108

  Fly   568 FLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSI-KVGVSEPGKTYVWRE 631
            :||      .:::..|.......:.:.|....|           |:..: ...|.:..|...||.
Frog  1109 YLE------ILDEHECNAASRPTDTQDCDNPSC-----------PKTLVTSPSVDQRPKHVQWRF 1156

  Fly   632 QGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPC 696
            ..:|.|||||..|.....::| |:..|.|.....|:...:| |.|..| ..|| ..|...|:|||
Frog  1157 GSWTPCSASCGRGNRARYVSC-RDAFGGVAEEPFCTHLPRP-AEVEPC-FTPC-GEWQSGDWTPC 1217

  Fly   697 SKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMC-PQPPPADRQYCNVLDC------------PV 748
            |.:||.|...|:|.|.....|..|       |.| .:..||..|.|.::.|            ||
Frog  1218 SVTCGKGKLMRQVICTSYNGRTED-------SNCDSETQPAAEQECIMVPCNKYIHYPFNHGYPV 1275

  Fly   749 R------------------------------WEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKI 783
            |                              |..|.|..||.||..||:.|.|.|      :.:.
Frog  1276 RNSQSANPHINREHDTSGSINHRNNLPRENQWRTGPWGACSSTCAGGFEQRMVVC------QDEE 1334

  Fly   784 ERPESMCPSA-KPADKKPCNVKPCPPEDPKPVIQINNSTHIQHDPKKTKITLKVGGAGLVFFGTQ 847
            .|..|:|..| ||.:.:.|:..|||
Frog  1335 GRSSSLCDEASKPVESRHCDSGPCP---------------------------------------- 1359

  Fly   848 VKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISIE 912
                           :||
Frog  1360 ---------------QWS----------------------------------------------- 1362

  Fly   913 VKAKPGQQIEELEQQETERLVREKSGTEALTSADMKSADGTGTSTAVGPNSHVNGSAQQHGSRRR 977
                                                                       ||:...
Frog  1363 -----------------------------------------------------------HGTWGE 1368

  Fly   978 QQQSERLQNGRERSRRPKSDGVQHADSSIMEDDLSQLVQSEDRIPQPASASSGGSRTRTLLAMPY 1042
            ..|:                                              ..||.|||.::.
Frog  1369 CTQT----------------------------------------------CGGGMRTRLVVC--- 1384

  Fly  1043 FQALLSNLQLLWPLQRFKDSRGQHLLQGEALKFGIDLSGKDFDQDESERVPAEQLPPEVLHSPSD 1107
                                   .|..|:.|.          ||:
Frog  1385 -----------------------QLTSGQVLD----------DQN-------------------- 1396

  Fly  1108 PEYHEPSKSGPEADVPHVPPHMPHARWETGAAASTTAVPSLPNDGFVYRWMLGEWSQCSQECGAA 1172
                        .::...||:|        |..:..|.|:   |.|   |..|.|..||..|
Frog  1397 ------------CEILDKPPNM--------AQCNNHACPA---DAF---WHPGPWKSCSASC--- 1432

  Fly  1173 GSGLQRRTVSCQRAAKATSSGSTSDTENNVVDNSECFAHGLELPEFFQSCGNEACPQWSKGDWTP 1237
            |.|::.|.|.|          .|.|  .:::|:..|  ..|:.|...:.|....||.|....|..
Frog  1433 GKGVKYRNVHC----------VTKD--KHIMDDQIC--QHLKKPRVRKYCKLGKCPSWKAKKWME 1483

  Fly  1238 CQRSHCHGRNTAMQRREVTCRYPNGTEGSI----CDEYERPAMRQECYNERC-EGVWRVEPWSEC 1297
            |..| |   ...:|||||.||...  :|.|    |:...||..:::|:...| ...|..:.|.:|
Frog  1484 CSVS-C---GIGIQRREVYCRLKG--QGKIQEEFCNSSTRPDSQKQCFLPECMHYFWLTDEWPDC 1542

  Fly  1298 NAPCGRKGIKYRILQCVWYGSRRPAGNVCKHQPRPAVMKVCKSPACQ----AQLSSSPAQLC--- 1355
            ::.|..|..:.|: :||.........|.|....:| :.|.||:..|:    .:..|..|.:|
Frog  1543 SSECKHKEYRRRV-RCVDSNKSPVNDNYCDPTTKP-LSKKCKNVPCKYIVVTEDMSKCAGICWYG 1605

  Fly  1356 -RDSSRYCR-----------NARAMGL--CRLHRYKL--KCCGS-CEQ 1386
             :....:|:           :.||:..  |.|..:..  ||.|: |.|
Frog  1606 YKHKRTFCQKVPATNNKNSTDLRAVSYKRCPLRPFPFAHKCNGNGCVQ 1653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	18/51 (35%)
		TSP1	546..600	CDD:214559	14/55 (25%)
		TSP1	750..807	CDD:214559	20/57 (35%)
		IGc2	845..902	CDD:197706	2/56 (4%)
		PLAC	1355..1384	CDD:285849	9/48 (19%)
adamts20	XP_002932868.3	Pep_M12B_propep	41..184	CDD:396235
		ZnMc_ADAMTS_like	261..467	CDD:239801	8/33 (24%)
		ADAM_CR_2	482..549	CDD:407643	11/66 (17%)
		TSP1	562..614	CDD:214559	18/51 (35%)
		ADAM_spacer1	724..842	CDD:368694	3/117 (3%)
		TSP1_ADAMTS	852..904	CDD:408800	14/53 (26%)
		TSP1_ADAMTS	910..962	CDD:408800	17/51 (33%)
		TSP1_ADAMTS	971..1023	CDD:408800	16/51 (31%)
		TSP1_ADAMTS	1026..1078	CDD:408800	15/95 (16%)
		TSP1_ADAMTS	1081..1135	CDD:408800	16/70 (23%)
		TSP1_ADAMTS	1154..1206	CDD:408800	18/54 (33%)
		TSP1_ADAMTS	1209..1261	CDD:408800	20/58 (34%)
		TSP1_ADAMTS	1307..1358	CDD:408800	19/56 (34%)
		TSP1_ADAMTS	1361..1414	CDD:408800	19/280 (7%)
		TSP1_ADAMTS	1420..1473	CDD:408800	18/69 (26%)
		TSP1_ADAMTS	1476..1529	CDD:408800	18/58 (31%)
		TSP1_ADAMTS	1657..1708	CDD:408800
		GON	1712..1908	CDD:400843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11921
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000