DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nolo and adamts18

DIOPT Version :9

Sequence 1:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_009301678.1	Gene:	adamts18 / 100150128	ZFINID:	ZDB-GENE-070815-1	Length:	1244	Species:	Danio rerio

Alignment Length:	947	Identity:	207/947 - (21%)
Similarity:	280/947 - (29%)	Gaps:	457/947 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 GP----GQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPC-PEQQ 127
            ||    ||||.||:||.|||||.||:|::.|.|.||..      |:|....:::||.:|| |:..
Zfish   590 GPKAVHGQWSGWSEWSDCSRTCGGGVMYRERSCNSPSPQHNGKFCQGPGRLHQLCNTKPCQPDGV 654

  Fly   128 DFRSSQCSAYNDVPYDGTLYKWTPHYDYVEP---CALTCRGHPAHLVEDISRETGDGNAEEAEHY 189
            |||:.||:.||..|:.|..|||.| |..||.   |.|.|                     .||.:
Zfish   655 DFRAQQCAEYNSKPFRGWYYKWKP-YTKVEEEDICKLYC---------------------IAEDF 697

  Fly   190 DEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCS---- 250
            |   ....:|::|:|||.|......:||.|.|:.||||..:||...:|.||||.||.::|.
Zfish   698 D---FFFAMSSKVKDGTSCSDYKGGVCIDGICEPVGCDQVLGSKAALDACGVCKGDNSTCKFYSG 759

  Fly   251 ----------------------------------------------------------------- 250

Zfish   760 QYTLQHRANEYYPVVMVPAGARSIQVQEMEISNSYLAVRSLKRGTYYLTADWTVDWPGRFQFAGT 824

  Fly   251 ----QPLFN-----------------------------WE--------------MAPMSQCSVTC 268
                |..||                             ||              ....|.||..|
Zfish   825 TFNYQRSFNRPETLFATGPTNETLLFEILLQGKNPGITWEYTLPHPEKKHNYTWSVVRSDCSAPC 889

  Fly   269 GSGYKMSRPIC-RNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYR 332
            ..|...::.|| :::.|  .|:.:||:...||......|||..||..|....|..|||.||.|.:
Zfish   890 AGGRVSTKAICLQDQQT--QVNSSLCNPQTRPVVGSHLCNTQPCPAYWTTGKWGVCSRTCGGGQQ 952

  Fly   333 ERMVVCAEESNGIKTRV-ADIMCRTPKPPTQETCIIEEC-PHWEVEDWTGCSVSCGQGIQMRGVE 395
            .|.:.|..:....:..| |..:|....|...:.|..:.| |.|....||.||.:||:|::.|.|.
Zfish   953 TRNIRCLRKVTYQREEVAAQSLCPVMAPAQLQPCNTQSCPPEWSTSSWTQCSKTCGRGLKKRSVF 1017

  Fly   396 CKSTDGSLSA------KCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDS 454
            |:|||....|      .|....||.:.:.|                  |.|....|||.:
Zfish  1018 CRSTDPGARAVVVPDSMCKLHLKPKAQESC------------------VLSRCPKNERLQ----- 1059

  Fly   455 SDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNG 519

Zfish  1060 ----------------------------------------------------------------- 1059

  Fly   520 NSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCE 584
                                 :| .:.|..||.:||.|:|||..:|
Zfish  1060 ---------------------WI-TSAWGECSASCGAGVRRRELHC------------------- 1083

  Fly   585 GKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELI 649
            |:|                          ||               :.|||...|.
Zfish  1084 GEK--------------------------DS---------------QGGYTEFPAR--------- 1098

  Fly   650 INCVREDNGRVVSPFLCSPETKPEARV-RTCNDRPCP----PR------------WNYSDYTPCS 697
                           .|....||||.: ::||:.|||    |:            |..|.:..|:
Zfish  1099 ---------------RCRNLQKPEADLEQSCNNGPCPEPLAPQLLQPGGPSVTLGWYSSPWLQCT 1148

  Fly   698 KSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMC-PQPPPADRQYCNVLDCPVRWEVGEWSKCSHT 761
            .|||.|::||.|||:.:..         |:..| |...|...:.||                :|
Zfish  1149 VSCGGGVQTRSVQCLRQGR---------PSVGCFPHQRPISSRACN----------------TH- 1187

  Fly   762 CGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCPPEDP-----KPVIQINNST 821
                                       .||:..|.        |.||..|     :|.|...:..
Zfish  1188 ---------------------------FCPAPIPV--------PVPPPSPTLKEDQPCIDFFSWC 1217

  Fly   822 HI--QHDPKKTKITLKVGGAGLVFFGTQVKIKCPVKR 856
            |:  ||           |.....|:|.|....|..||
Zfish  1218 HLVPQH-----------GVCNHKFYGQQCCKSCSAKR 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	24/52 (46%)
		TSP1	546..600	CDD:214559	12/53 (23%)
		TSP1	750..807	CDD:214559	5/56 (9%)
		IGc2	845..902	CDD:197706	5/12 (42%)
		PLAC	1355..1384	CDD:285849
adamts18	XP_009301678.1	Pep_M12B_propep	86..206	CDD:279848
		ZnMc_ADAMTS_like	299..500	CDD:239801
		Reprolysin	301..504	CDD:279729
		TSP1	598..649	CDD:214559	22/50 (44%)
		ADAM_spacer1	755..868	CDD:283607	5/112 (4%)
		TSP1	935..992	CDD:214559	15/56 (27%)
		TSP1	995..1053	CDD:214559	21/75 (28%)
		TSP1	1060..1120	CDD:214559	27/144 (19%)
		TSP1	1142..1189	CDD:214559	18/99 (18%)
		PLAC	1210..1240	CDD:285849	8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11660
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810