Protein Alignment eEF2 and EFTUD2

DIOPT Version :10

• Sequence 1: NP_525105.2
• Gene: eEF2 / 35422
• FlyBaseID: FBgn0000559
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_004238.3
• Gene: EFTUD2 / 9343
• HGNCID: 30858
• Length: 972
• Species: Homo sapiens
• Alignment Length: 868
• Identity: 331/868 - (38%)
• Similarity: 511/868 - (58%)
• Gaps: 56/868 - (6%)

  Fly     4 FTVDEIRGLMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETR--------FTDTR 60
            :.:|.:..|||....|||:::..|:.|||:...|.|:.:.       ..|.|        :||..
Human   114 YEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQT-------HPEIRKRYDQDLCYTDIL 171

  Fly    61 KDEQERCITIKSTAISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRV 125
            ..||||.:.||||.::            :..||.:.   |.:|.|::|:||||:||.||||.||:
Human   172 FTEQERGVGIKSTPVT------------VVLPDTKG---KSYLFNIMDTPGHVNFSDEVTAGLRI 221

  Fly   126 TDGALVVVDCVSGVCVQTETVLRQAIAERIKPILFMNKMDRALLELQLDAEELYQTFQRIVENVN 190
            :||.::.:|...||.:.||.:::.|:.||:...:.:||:||.:|||:|...:.|...:.||:.||
Human   222 SDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVN 286

  Fly   191 VIIATYNDDGGPMGEVRVDPSKGSVGFGSGLHGWAFTLKQFSEMYSEKF-KIDVVKLMNRLWGEN 254
            .:|:.|:.|    ..:.:.|..|:|.|.|..:...|||..|:::|::.| .|:..:...||||:.
Human   287 GLISMYSTD----ENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDI 347

  Fly   255 FFNAKTKKW-QKQKEADNKRSFCMYILDPIYKVFDAIMNYKKEEIGTLLEKIGVTLKHEDKDKDG 318
            :||.||:|: :|...:.::|||..:||:|:||:...::......:...|:::|:.|..|:...:.
Human   348 YFNPKTRKFTKKAPTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNI 412

  Fly   319 KALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRMEMLYEGPHDDEAAIAVKSCDPDGPLMMY 383
            :.||:.|.:.:.......:.|...|:|||.|..|.::|..|.|..|.:...|:..||||||||.:
Human   413 RPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCH 477

  Fly   384 ISKMVPTSDKGRFYAFGRVFAGKVATGQKCRIMGPNYTPGKKEDLYEKAIQRTILMMGRYVEAIE 448
            .:||..|.|..:|:|||||.:|.:..||..:::|.|||...:||.....:.|..:.:.||...:.
Human   478 TTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIEVN 542

  Fly   449 DVPSGNICGLVGVDQFLVKTGTITT---FKDAHNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGL 510
            .||:||...:.||||.:|||.|||.   .::|...:.:||:.:.|:::||||.||::|||:::||
Human   543 RVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGL 607

  Fly   511 KRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQ 575
            :::.||.|.:...:||||||:|.|.|||:|:..:.||.:.::.|.:|.:||||::.|||.|.|..
Human   608 RKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSL 672

  Fly   576 MCLSKSPNKHNRLLMKALPMPDGLPEDIDNGDVSAKDEFKARARYLSEKYDYDVTEARKIWCFGP 640
            .|.:::|||.|::.|.|.|:..||.|||:|..|......|....:...|||:|:..||.||.|||
Human   673 KCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARSIWAFGP 737

  Fly   641 DGTGPNFILDCTKSVQ----YLNEIKDSVVAGFQWASKEGILADENLRGVRFNIYDVTLHADAIH 701
            |.||||.::|.|...:    .|..:|||:|.||||.::||.|.||.:|.|:|.|.|..:..:.:|
Human   738 DATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCDELIRNVKFKILDAVVAQEPLH 802

  Fly   702 RGGGQIIPTTRRCLYAAAITAKPRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEENQVVGTP 766
            |||||||||.||.:|:|.:.|.||||||.|..|:|.|...|..:|.||.||||||.::..:.|:|
Human   803 RGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSP 867

  Fly   767 MFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGD---------PSEPSSKPY---A 819
            ::.:||::|..:||||..|||::|.||||...||.|||::|||         |.||...|:   .
Human   868 LYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLARE 932

  Fly   820 IVQDTRKRKGLKEGLPDLSQYLD 842
            .:..||:||||.|.: .:|::.|
Human   933 FMIKTRRRKGLSEDV-SISKFFD 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	331/868 (38%)
EFTUD2	NP_004238.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54
		EFTUD2	4..110	CDD:464968
		PRK13351	122..954	CDD:481252	329/858 (38%)