DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF2 and EFTUD2

DIOPT Version :9

Sequence 1:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001245282.1	Gene:	EFTUD2 / 9343	HGNCID:	30858	Length:	972	Species:	Homo sapiens

Alignment Length:	868	Identity:	331/868 - (38%)
Similarity:	511/868 - (58%)	Gaps:	56/868 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FTVDEIRGLMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETR--------FTDTR 60
            :.:|.:..|||....|||:::..|:.|||:...|.|:.:.       ..|.|        :||..
Human   114 YEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQT-------HPEIRKRYDQDLCYTDIL 171

  Fly    61 KDEQERCITIKSTAISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRV 125
            ..||||.:.||||.::            :..||.:.   |.:|.|::|:||||:||.||||.||:
Human   172 FTEQERGVGIKSTPVT------------VVLPDTKG---KSYLFNIMDTPGHVNFSDEVTAGLRI 221

  Fly   126 TDGALVVVDCVSGVCVQTETVLRQAIAERIKPILFMNKMDRALLELQLDAEELYQTFQRIVENVN 190
            :||.::.:|...||.:.||.:::.|:.||:...:.:||:||.:|||:|...:.|...:.||:.||
Human   222 SDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVN 286

  Fly   191 VIIATYNDDGGPMGEVRVDPSKGSVGFGSGLHGWAFTLKQFSEMYSEKF-KIDVVKLMNRLWGEN 254
            .:|:.|:.|    ..:.:.|..|:|.|.|..:...|||..|:::|::.| .|:..:...||||:.
Human   287 GLISMYSTD----ENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDI 347

  Fly   255 FFNAKTKKW-QKQKEADNKRSFCMYILDPIYKVFDAIMNYKKEEIGTLLEKIGVTLKHEDKDKDG 318
            :||.||:|: :|...:.::|||..:||:|:||:...::......:...|:::|:.|..|:...:.
Human   348 YFNPKTRKFTKKAPTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNI 412

  Fly   319 KALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRMEMLYEGPHDDEAAIAVKSCDPDGPLMMY 383
            :.||:.|.:.:.......:.|...|:|||.|..|.::|..|.|..|.:...|:..||||||||.:
Human   413 RPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCH 477

  Fly   384 ISKMVPTSDKGRFYAFGRVFAGKVATGQKCRIMGPNYTPGKKEDLYEKAIQRTILMMGRYVEAIE 448
            .:||..|.|..:|:|||||.:|.:..||..:::|.|||...:||.....:.|..:.:.||...:.
Human   478 TTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIEVN 542

  Fly   449 DVPSGNICGLVGVDQFLVKTGTITT---FKDAHNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGL 510
            .||:||...:.||||.:|||.|||.   .::|...:.:||:.:.|:::||||.||::|||:::||
Human   543 RVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGL 607

  Fly   511 KRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQ 575
            :::.||.|.:...:||||||:|.|.|||:|:..:.||.:.::.|.:|.:||||::.|||.|.|..
Human   608 RKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSL 672

  Fly   576 MCLSKSPNKHNRLLMKALPMPDGLPEDIDNGDVSAKDEFKARARYLSEKYDYDVTEARKIWCFGP 640
            .|.:::|||.|::.|.|.|:..||.|||:|..|......|....:...|||:|:..||.||.|||
Human   673 KCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARSIWAFGP 737

  Fly   641 DGTGPNFILDCTKSVQ----YLNEIKDSVVAGFQWASKEGILADENLRGVRFNIYDVTLHADAIH 701
            |.||||.::|.|...:    .|..:|||:|.||||.::||.|.||.:|.|:|.|.|..:..:.:|
Human   738 DATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCDELIRNVKFKILDAVVAQEPLH 802

  Fly   702 RGGGQIIPTTRRCLYAAAITAKPRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEENQVVGTP 766
            |||||||||.||.:|:|.:.|.||||||.|..|:|.|...|..:|.||.||||||.::..:.|:|
Human   803 RGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSP 867

  Fly   767 MFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGD---------PSEPSSKPY---A 819
            ::.:||::|..:||||..|||::|.||||...||.|||::|||         |.||...|:   .
Human   868 LYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLARE 932

  Fly   820 IVQDTRKRKGLKEGLPDLSQYLD 842
            .:..||:||||.|.: .:|::.|
Human   933 FMIKTRRRKGLSEDV-SISKFFD 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	331/868 (38%)
		EF2	20..236	CDD:206672	73/223 (33%)
		EF2_snRNP_like_II	380..474	CDD:293901	38/96 (40%)
		EF2_snRNP_III	489..560	CDD:293918	31/70 (44%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	83/175 (47%)
		eEF2_snRNP_like_C	728..807	CDD:239763	38/78 (49%)
EFTUD2	NP_001245282.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
		EFTUD2	4..110	CDD:406414
		FusA	122..954	CDD:357662	329/858 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720