Protein Alignment eEF2 and RIA1

DIOPT Version :10

• Sequence 1: NP_525105.2
• Gene: eEF2 / 35422
• FlyBaseID: FBgn0000559
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_014236.1
• Gene: RIA1 / 855558
• SGDID: S000005107
• Length: 1110
• Species: Saccharomyces cerevisiae
• Alignment Length: 1099
• Identity: 316/1099 - (28%)
• Similarity: 475/1099 - (43%)
• Gaps: 313/1099 - (28%)

  Fly    19 IRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTRKDEQERCITIKSTAISMYFEVEE 83
            |||:.::|||||||::|:|||::..|||:...||:.||.|.|.|||.|.||::|:|||:||.|..
Yeast    19 IRNICIVAHVDHGKTSLSDSLLASNGIISQRLAGKIRFLDARPDEQLRGITMESSAISLYFRVLR 83

  Fly    84 KDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLR 148
            |      .....|......|:||||||||:||||||:||.|:.|||:|:||.|.|||.||.||||
Yeast    84 K------QEGSDEPLVSEHLVNLIDSPGHIDFSSEVSAASRLCDGAVVLVDVVEGVCSQTVTVLR 142

  Fly   149 QAIAERIKPILFMNKMDRALLELQLDAEELYQTFQRIVENVNVIIATY----------------- 196
            |...|::||||.:||:||.:.||||..:|.|....:::|.||.:|.::
Yeast   143 QCWTEKLKPILVLNKIDRLITELQLTPQEAYIHLSKVIEQVNSVIGSFFANERQLDDLFWREQLE 207

  Fly   197 ---------NDDGGPMGEVRVDPSKGSVGFGSGLHGWAFTLKQFSEMYSEKFKIDVVKLMNRLWG 252
                     .||.|    :..:|:..:|.|.|.:.||.|.:.|.::.|.:|.......|...|||
Yeast   208 KNENAEYIEKDDSG----IYFNPTDNNVIFASAIDGWGFNIGQLAKFYEQKLGAKRENLQKVLWG 268

  Fly   253 ENFFNAKTKKWQKQKEADN---KRSFCMYILDPIYKVFDAIMNYKKEEIGTLLEKIGVTLK---- 310
            :.:.:.||||....|....   |..|...||:.|:|::..|:..:..|   ::|||..||.
Yeast   269 DFYMDPKTKKIINNKGLKGRSLKPLFTSLILENIWKIYQNIITSRDSE---MVEKIAKTLNIKLL 330

  Fly   311 -HEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRMEMLYEGPHDDEAAI----- 369
             .:.:.||.|.||:|:|..|||...|:|..:...||||:.:|..|:..:... ..|.||:
Yeast   331 ARDLRSKDDKQLLRTIMGQWLPVSTAVLLTVIEKLPSPLESQTDRLNTILVS-ESDTAAMDPRLL 394

  Fly   370 -AVKSCDPDGPLMMYISKM--------------VPTSD-------KGR----------------- 395
             |:|:||.:||:..|:|||              :.:||       |.|
Yeast   395 KAMKTCDKEGPVSAYVSKMLSIPREELPVESKRIASSDELMERSRKAREEALNAAKHAGMVENMA 459

  Fly   396 ----------------------------------------------------------------- 395
                                                                             
Yeast   460 MMDLNDNSKNTSDLYKRAKDTVMTPEVGEQTKPKPSRNNDVFCVVSEPSSALDLEFEYEGEDDSD 524

  Fly   396 ---------------------------------------------------------FYAFGRVF 403
                                                                     ..||.|::
Yeast   525 SQDNFGLDFVPTDIDPNDPLSSMFEYEEEDPLLESIKQISEDVNDEVDDIFDEKEECLVAFARIY 589

  Fly   404 AGKVATGQKCRIMGPNYTPGKKEDLYEKA-IQRTILMMGRYVEAIEDVPSGNICGLVGVDQFLVK 467
            :|.:..||:..::||.|.|...|:..|.| |....|.||:.:..::..|||||.|:.|:...::|
Yeast   590 SGTLRVGQEISVLGPKYDPKCPEEHIETAIITHLYLFMGKELVPLDVCPSGNIVGIRGLAGKVLK 654

  Fly   468 TGT-ITTFKDAHNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHI 531
            :|| |.......|:..:.|..:|:|||||||.||.::.|||.|||.|.::||.|...:|.:||||
Yeast   655 SGTLIEKGVQGVNLAGVNFHFTPIVRVAVEPANPVEMSKLVRGLKLLDQADPCVHTYVENTGEHI 719

  Fly   532 IAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESD--------------QMCLSKSP 582
            :..|||||||.|||||.|..|.|.:..|:|.:.||||....||              ::.||:
Yeast   720 LCTAGELHLERCLKDLTERFAGIEITHSEPAIPYRETFLSASDMNPPQNSQLGRGVHELLLSQ-- 782

  Fly   583 NKHNRLLMKALPMPDGLPEDIDNGDVSAKDEFKAR------------ARYLSEK-----YDYDVT 630
               .::..:..|:...:.:.:.....|.|:..|..            :.:|.:|     ::..:.
Yeast   783 ---YKITFRTFPLSGKVTDFLSQHQNSIKNILKTSTSSMDPVIESTGSSFLDKKSLLVAFEEVIN 844

  Fly   631 EAR-----------KIWCFGPDGTGPNFILDCTKSVQYL-------NEIKDSVVAGFQWASKEGI 677
            :..           |:..|||...|.|.:|.....:..|       .|..||:..|||.|..||.
Yeast   845 QEEKSRELLSGFKVKLAGFGPSRVGCNILLSQDNLLGSLFEGTPAAFEYSDSIKNGFQLAVSEGP 909

  Fly   678 LADENLRGVRFNIYDVTLHADAIHRG--------------------GGQIIPTTRRCLYAAAITA 722
            ||:|.::|       :.:..:::|:.                    .|::|.:||..::.|.:..
Yeast   910 LANEPVQG-------MCVLVESVHKMSQDEIESIEDPRYQQHIVDLSGRLITSTRDAIHEAFLDW 967

  Fly   723 KPRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEENQVVGTPMFVVKAYLPVNESFGFTADLR 787
            .||:|..:|.|:||.....:|.:|.|:.:|.|.:..|....|||.|.::|::||.|:||.:.|:|
Yeast   968 SPRIMWAIYSCDIQTSVDVLGKVYAVILQRHGKIISEEMKEGTPFFQIEAHVPVVEAFGLSEDIR 1032

  Fly   788 SNTGGQAFPQCVFDHWQVLPGDP-----SEPSSKPYAIVQD-----------TRKRKGL 830
            ..|.|.|.||.||..::.:..||     :|...:......|           .|:||||
Yeast  1033 KRTSGAAQPQLVFSGFECIDLDPFWVPTTEEELEELGDTADRENIARKHMNAIRRRKGL 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	316/1099 (29%)
RIA1	NP_014236.1	PRK13351	1..1091	CDD:481252	314/1097 (29%)