DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF2 and GFM1

DIOPT Version :9

Sequence 1:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001295093.1	Gene:	GFM1 / 85476	HGNCID:	13780	Length:	770	Species:	Homo sapiens

Alignment Length:	861	Identity:	216/861 - (25%)
Similarity:	340/861 - (39%)	Gaps:	222/861 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IRNMSVIAHVDHGKSTLTDSLVSKAGIIA-----GAKAGETRFTDTRKDEQERCITIKSTA-ISM 77
            |||:.:.||:|.||:|||:.::...|.||     ..|.|.....|:.:.|::|.|||:|.| .:|
Human    46 IRNIGISAHIDSGKTTLTERVLYYTGRIAKMHEVKGKDGVGAVMDSMELERQRGITIQSAATYTM 110

  Fly    78 YFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQ 142
            :.:|.                     ||:||:||||||:.||..||||.|||::|:..|.||..|
Human   111 WKDVN---------------------INIIDTPGHVDFTIEVERALRVLDGAVLVLCAVGGVQCQ 154

  Fly   143 TETVLRQAIAERIKPILFMNKMDR--------------------ALLELQLDAEELYQTFQRIVE 187
            |.||.||.....:..:.|:||:||                    |.:::.:..|..::....::|
Human   155 TMTVNRQMKRYNVPFLTFINKLDRMGSNPARALQQMRSKLNHNAAFMQIPMGLEGNFKGIVDLIE 219

  Fly   188 NVNVIIATYNDDGGPMGEVRVDPSKGSVGFGSGLHGW----AFTLKQFSEMYSE---------KF 239
            .    .|.|.|  |..|....|       |...|..|    ...:.::.|:.:|         :.
Human   220 E----RAIYFD--GDFGHFLRD-------FLPLLWNWDRRSGSQIVRYGEIPAELRAAATDHRQE 271

  Fly   240 KIDVVKLMNRLWGENFFNAKTKKWQKQK----EADNKRSFCMYILDPIYKVFDAIMNYKKEEIGT 300
            .|:.|...:...||.|...|.......|    .|..||||     .|::             :|:
Human   272 LIECVANSDEQLGEMFLEEKIPSISDLKLAIRRATLKRSF-----TPVF-------------LGS 318

  Fly   301 LLEKIGVTLKHEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRMEMLYEGPHDD 365
            .|:..||                          :.||..:..:||:|...|.|.:....:...:.
Human   319 ALKNKGV--------------------------QPLLDAVLEYLPNPSEVQNYAILNKEDDSKEK 357

  Fly   366 EAAIAVKSCDPDGPLMMYISKMVPTSDKGRF--YAFGRVFAGKVATGQKCRIMGPNYTPGKKEDL 428
            ...:...|.|...|.:....|:    :.|||  ..:.|.:.|::..|....    |....||..|
Human   358 TKILMNSSRDNSHPFVGLAFKL----EVGRFGQLTYVRSYQGELKKGDTIY----NTRTRKKVRL 414

  Fly   429 YEKAIQRTILMMGRYVEAIEDVPSGNICGLVGVDQFLVKTGTITTFKDAHNMKVMKFSV---SPV 490
                 ||...|....:|.:|:|.:|:||.|.|:|     ..:..||.|..|..:...|:   .||
Human   415 -----QRLARMHADMMEDVEEVYAGDICALFGID-----CASGDTFTDKANSGLSMESIHVPDPV 469

  Fly   491 VRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCIIE-ESGEHIIAGAGELHLEICLKDLEEDHACI 554
            :.:|::|.|..||.|..:|:.|..:.||..:...: |:.|.:|:|.|||||||..:.||.::.|
Human   470 ISIAMKPSNKNDLEKFSKGIGRFTREDPTFKVYFDTENKETVISGMGELHLEIYAQRLEREYGC- 533

  Fly   555 PLKKSDPVVSYRETVSEESDQMCLSKSPNKHNRLLMKALPMPDGLPEDIDNGDVSAKDEFKARAR 619
            |.....|.|::|||::                      .|:|         .|.:.|.:.....:
Human   534 PCITGKPKVAFRETIT----------------------APVP---------FDFTHKKQSGGAGQ 567

  Fly   620 YLS--------EKYDYDVTEARKIWCFGPDGTGPNFILDCTKSVQYLNEIKDSVVAGFQWASKEG 676
            |..        :..||...|      |..:..|.|.          ..:...:|..||..|.::|
Human   568 YGKVIGVLEPLDPEDYTKLE------FSDETFGSNI----------PKQFVPAVEKGFLDACEKG 616

  Fly   677 ILADENLRGVRFNIYDVTLH-ADA-----IHRGGGQIIPTTRRCLYAAAITAKPRLMEPVYLCEI 735
            .|:...|.|:||.:.|...| .|:     |..|.|        .|..|...|...::||:...|:
Human   617 PLSGHKLSGLRFVLQDGAHHMVDSNEISFIRAGEG--------ALKQALANATLCILEPIMAVEV 673

  Fly   736 QCPEVAVGGIYGVLNRRRGHVFEENQVVGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVF 800
            ..|....|.:...:|||.|.:..::.|  ...|.:.|.:|:|:.||::.:|||.|.|:......:
Human   674 VAPNEFQGQVIAGINRRHGVITGQDGV--EDYFTLYADVPLNDMFGYSTELRSCTEGKGEYTMEY 736

  Fly   801 DHWQVLPGDPSEPSSK 816
            ..:|     |..||::
Human   737 SRYQ-----PCLPSTQ 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	216/861 (25%)
		EF2	20..236	CDD:206672	72/245 (29%)
		EF2_snRNP_like_II	380..474	CDD:293901	23/95 (24%)
		EF2_snRNP_III	489..560	CDD:293918	27/71 (38%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	37/185 (20%)
		eEF2_snRNP_like_C	728..807	CDD:239763	22/78 (28%)
GFM1	NP_001295093.1	EF-G	48..339	CDD:206673	93/368 (25%)
		PRK12740	52..751	CDD:237186	213/855 (25%)
		mtEFG1_II_like	372..452	CDD:293908	25/97 (26%)
		EFG_III	466..541	CDD:293919	27/75 (36%)
		EFG_mtEFG1_IV	544..660	CDD:238715	32/170 (19%)
		mtEFG1_C	666..743	CDD:239764	23/83 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810