Protein Alignment eEF2 and MEF1

DIOPT Version :10

• Sequence 1: NP_525105.2
• Gene: eEF2 / 35422
• FlyBaseID: FBgn0000559
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_013170.1
• Gene: MEF1 / 850758
• SGDID: S000004059
• Length: 761
• Species: Saccharomyces cerevisiae
• Alignment Length: 889
• Identity: 217/889 - (24%)
• Similarity: 354/889 - (39%)
• Gaps: 242/889 - (27%)

  Fly     6 VDEIR--------GLMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKAGII-----------AGAKA 51
            ||||:        |..:|   :||:.:.||:|.||:|.|:.::.....|           .|||
Yeast    52 VDEIKQKLTPDDIGRCNK---LRNIGISAHIDSGKTTFTERVLYYTKRIKAIHEVRGRDNVGAK- 112

  Fly    52 GETRFTDTRKDEQERCITIKSTAISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFS 116
                 .|:...|:|:.|||:|.|....:                :||.|.:..||||:|||:||:
Yeast   113 -----MDSMDLEREKGITIQSAATYCSW----------------DKEGKNYHFNLIDTPGHIDFT 156

  Fly   117 SEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPILFMNKMDR--------------- 166
            .||..||||.|||::||..||||..||.||.||.....:..:.|:|||||
Yeast   157 IEVERALRVLDGAVLVVCAVSGVQSQTVTVDRQMRRYNVPRVTFINKMDRMGSDPFRAIEQLNSK 221

  Fly   167 -----ALLELQLDAEELYQTFQRIVENVNVIIATYNDDGGPMGEVRVDPSKGSVGFGSGLHGWAF 226
                 |.:::.:.:|   .:...:|:.:| .:|.||.  |..||:   ..||.|         ..
Yeast   222 LKIPAAAVQIPIGSE---SSLSGVVDLIN-RVAIYNK--GDNGEI---IEKGPV---------PE 268

  Fly   227 TLKQFSEMYSEKFKIDVVKLMNRLWGENFFNAKTKKWQKQKEADNK----RSFCMYILDP----- 282
            .||...| ...:..|:.:..::....|.|...|....|:.|:|..:    |||...::..
Yeast   269 NLKPLME-EKRQLLIETLADVDDEMAEMFLEEKEPTTQQIKDAIRRSTIARSFTPVLMGSALANT 332

  Fly   283 -IYKVFDAIMNY---KKEEIGTLLEKIGVTLKHEDKDKDGKALLKTVMRTWLPAGEALLQMIAIH 343
             |..|.|||::|   ..|.:.|.|:.         .:.:.|..|       :||
Yeast   333 GIQPVLDAIVDYLPNPSEVLNTALDV---------SNNEAKVNL-------VPA----------- 370

  Fly   344 LPSPVVAQKYRMEMLYEGPHDDEAAIAVKSCDPDGPLMMYISKMVPTSDKGRFYAFGRVFAGKVA 408
            :..|.|...:::|   ||.:..               :.|:                ||:.|::.
Yeast   371 VQQPFVGLAFKLE---EGKYGQ---------------LTYV----------------RVYQGRLR 401

  Fly   409 TGQKCRIMGPNYTPGKKEDLYEKAIQRTILMMGRYVEAIEDVPSGNICGLVGVDQFLVKTGTITT 473
            .|...    .|...|||     ..:.|.:.|....:|.:::|.||.||...|:|     ..:..|
Yeast   402 KGNYI----TNVKTGKK-----VKVARLVRMHSSEMEDVDEVGSGEICATFGID-----CASGDT 452

  Fly   474 FKDA---HNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCIIE-ESGEHIIAG 534
            |.|.   ::|..| :....||.:::.| |..|.....:.|.|..|.||..:...: ||.|.||:|
Yeast   453 FTDGSVQYSMSSM-YVPDAVVSLSITP-NSKDASNFSKALNRFQKEDPTFRVKFDPESKETIISG 515

  Fly   535 AGELHLEICLKDLEEDH--ACIPLKKSDPVVSYRETVSEESD----QMCLSKSPNKHNRLLMKAL 593
            .|||||||.::.:..::  .|:..|   |.|||||:::..:|    ....|....::.|::....
Yeast   516 MGELHLEIYVERMRREYNVDCVTGK---PQVSYRESITIPADFDYTHKKQSGGAGQYGRVIGTLS 577

  Fly   594 PMPDGLPEDIDNGDVSAKDEFKARARYLSEKYDYDVTEARKIWCFGPDGTGPNFILDCTKSVQYL 658
            |:     :||..|::                ::..:...|.     ||    .::..|.|
Yeast   578 PV-----DDITKGNI----------------FETAIVGGRI-----PD----KYLAACGK----- 607

  Fly   659 NEIKDSVVAGFQWASKEGILADENLRGVRFNIYDVTLHADAIHRGGGQIIPTTRRCLYAAAITAK 723
                     ||:...::|.|....:..|:..|.|..:|  |:..........|......|.:.|:
Yeast   608 ---------GFEEVCEKGPLIGHRVLDVKMLINDGAIH--AVDSNELSFKTATMSAFRDAFLRAQ 661

  Fly   724 PRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFE-ENQVVGTPMFVVKAYLPVNESFGFTADLR 787
            |.:|||:....:..|....|.:.|:||:.:..:.: ||   |...|.:||...::..|||...||
Yeast   662 PVIMEPIMNVSVTSPNEFQGNVIGLLNKLQAVIQDTEN---GHDEFTLKAECALSTMFGFATSLR 723

  Fly   788 SNTGGQAFPQCVFDHWQVLPGDPSEPSSKPYAIVQDTRKRKGLK 831
            ::|.|:......|.|:.     |:.|..:. .::.:.:|::..|
Yeast   724 ASTQGKGEFSLEFSHYA-----PTAPHVQK-ELISEFQKKQAKK 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	217/889 (24%)
MEF1	NP_013170.1	FusA	68..759	CDD:440248	211/869 (24%)