DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF2 and AT3G22980

DIOPT Version :9

Sequence 1:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001319621.1	Gene:	AT3G22980 / 821872	AraportID:	AT3G22980	Length:	1015	Species:	Arabidopsis thaliana

Alignment Length:	1023	Identity:	307/1023 - (30%)
Similarity:	488/1023 - (47%)	Gaps:	226/1023 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VDEIRGLMDKKRNIRNMSVIAHVDHGKSTLTDSLV--SKAGIIAGAKAGETRFTDTRKDEQERCI 68
            :||..|     |.:||:.::|||||||:||.|.|:  |..|::....||:.||.|...:||.|.|
plant     1 MDESEG-----RKVRNICILAHVDHGKTTLADHLIASSGGGVLHPRLAGKLRFMDYLDEEQRRAI 60

  Fly    69 TIKSTAISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGALVVV 133
            |:||::||:.:                    |.:.:||||||||:||.|||:.|.|::|||||:|
plant    61 TMKSSSISLKY--------------------KDYSLNLIDSPGHMDFCSEVSTAARLSDGALVLV 105

  Fly   134 DCVSGVCVQTETVLRQAIAERIKPILFMNKMDRALLELQLDAEELYQTFQRIVENVNVIIATYND 198
            |.|.||.:||..|||||..|::.|.|.:||:||.:.||:|...|.|....|||..||.|::.|..
plant   106 DAVEGVHIQTHAVLRQAWIEKLTPCLVLNKIDRLIFELRLSPMEAYTRLIRIVHEVNGIVSAYKS 170

  Fly   199 D----------GGPMG--------------EVRVDPSKGSVGFGSGLHGWAFTLKQFSEMYSEKF 239
            :          ..|.|              ||...|.||:|.|...|.||.|.:.:|:..|:.|.
plant   171 EKYLSDVDSILASPSGELSAESLELLEDDEEVTFQPQKGNVVFVCALDGWGFGIAEFANFYASKL 235

  Fly   240 KIDVVKLMNRLWGENFFNAKTKK--WQKQKEADNKRS--FCMYILDPIYKVFDAIMNYKKEEIGT 300
            ......|...|||..::..|||.  .:|...|.:|..  |..::|:|:::|::|.::...::  .
plant   236 GASATALQKSLWGPRYYIPKTKMIVGKKNLSAGSKAKPMFVQFVLEPLWQVYEAALDPGGDK--A 298

  Fly   301 LLEKIGVTLK-----HEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRMEMLYE 360
            :|||:..:..     .|.::||.|.:|::||..|||..:|:|.|...|||.|:.||.||:..|..
plant   299 VLEKVIKSFNLSIPPRELQNKDPKNVLQSVMSRWLPLSDAVLSMAVKHLPDPIAAQAYRIPRLVP 363

  Fly   361 -----GPHDDEAAI---------AVKSCD--PDGPLMMYIS-------KMVPTSDKGR------- 395
                 |..|.::::         ::::||  .|.|.::::|       ||:|.....|
plant   364 ERKIIGGDDVDSSVLAEAELVRKSIEACDSSSDSPCVVFVSKMFAIPMKMIPQDGNHRERMNGLN 428

  Fly   396 -----------FYAFGRVFAGKVATGQKCRIMGPNYTPGKKED----LYEKAIQRTILMMGRYVE 445
                       |.||.|:|:|.:..||:..::...|.|.|.|.    :.|..:....||||:.:.
plant   429 DDDSKSESDECFLAFARIFSGVLRAGQRVFVITALYDPLKGESSHKYIQEAELHSLYLMMGQGLT 493

  Fly   446 AIEDVPSGNICGLVGVDQFLVKTGTITTFKDAHNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGL 510
            .:.:|.:||:..:.|:..::.|:.|:::.::...:..|:|.|||.:|||:||.:|||:..|::||
plant   494 PVTEVKAGNVVAIRGLGPYISKSATLSSTRNCWPLASMEFQVSPTLRVAIEPSDPADMSALMKGL 558

  Fly   511 KRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQ 575
            :.|.::||.|:..:...|||::|.|||:|||.|:|||:|..|.:.|:.|.|:||||||:..:...
plant   559 RLLNRADPFVEITVSARGEHVLAAAGEVHLERCVKDLKERFAKVNLEVSPPLVSYRETIEGDGSN 623

  Fly   576 MCLS--------------KSPNKHNRLLMKALPMPDGLPEDIDN-----GDV-------SAKDEF 614
            :..|              ::||....:.:..:.:|..|.:.:|.     ||:       |.| ..
plant   624 LLESLRSLSLNSSDYIEKRTPNGRCIIRVHVMKLPHALTKLLDENTELLGDIIGGKGSHSVK-IL 687

  Fly   615 KARARYLSEKYD------YDVTEA-----------------------RKIWCFGPDGTGPN---- 646
            :::...|.|..|      ..:.||                       ::||..||...|||
plant   688 ESQKPSLGENVDPIEELKKQLVEAGVSSSSETEKDREKCKTEWSKLLKRIWALGPREKGPNILFA 752

  Fly   647 -------------------------FILDCTKSVQYLNE---------IKDSVVAGFQWASKEGI 677
                                     |..|.|::...::|         ::.|:|:|||.|:..|.
plant   753 PDGKRIAEDGSMLVRGSPHVSQRLGFTEDSTETPAEVSETALYSEALTLESSIVSGFQLATASGP 817

  Fly   678 LADENLRGVRFNIYDVTLHADAIHRG--------GGQIIPTTRRCLYAAAITAKPRLMEPVYLCE 734
            |.||.:.|:.|.|......|:.:...        .||::...:....||.:...||::|.:|.||
plant   818 LCDEPMWGLAFTIESHLAPAEDVETDKPENFGIFTGQVMTAVKDACRAAVLQTNPRIVEAMYFCE 882

  Fly   735 IQCPEVAVGGIYGVLNRRRGHVFEENQVVGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCV 799
            :......:|.:|.||:|||..:.:|....|:.:|.|.||:||:|||||..:||..|.|.|....|
plant   883 LNTAPEYLGPMYAVLSRRRARILKEEMQEGSSLFTVHAYVPVSESFGFADELRKGTSGGASALMV 947

  Fly   800 FDHWQVLPGDP-----SEPSSKPYA------------IVQDTRKRKGL 830
            ..||::|..||     :|...:.:.            ::...|:||||
plant   948 LSHWEMLEEDPFFVPKTEEEIEEFGDGASVLPNTARKLINAVRRRKGL 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	307/1023 (30%)
		EF2	20..236	CDD:206672	95/241 (39%)
		EF2_snRNP_like_II	380..474	CDD:293901	28/122 (23%)
		EF2_snRNP_III	489..560	CDD:293918	33/70 (47%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	54/272 (20%)
		eEF2_snRNP_like_C	728..807	CDD:239763	32/78 (41%)
AT3G22980	NP_001319621.1	FusA	1..998	CDD:357662	307/1023 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820