DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF2 and mEFTu1

DIOPT Version :9

Sequence 1:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001163144.1	Gene:	mEFTu1 / 44438	FlyBaseID:	FBgn0024556	Length:	489	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	108/560 - (19%)
Similarity:	179/560 - (31%)	Gaps:	229/560 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETR---FTDTRKDEQERCITIKSTAISMYFEVE 82
            |:..|.||||||:|||.::..   ::|..:..|::   ..|...:|:.|.|||.
  Fly    84 NVGTIGHVDHGKTTLTAAITK---VLADKQLAESKKYNEIDNAPEEKARGITIN----------- 134

  Fly    83 EKDLVFITHPD-QREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETV 146
                  :.|.: |.|....|.    .|.|||.|:...:.......|||::||....|...||..
  Fly   135 ------VAHVEYQTETRHYGH----TDCPGHADYIKNMITGTAQMDGAILVVAATDGAMPQTRE- 188

  Fly   147 LRQAIAERI---KPILFMNKMDRALLELQLDAEELYQTFQRIVENVNVIIATYNDDGGPMGEVRV 208
             ...:|::|   ..::|:||:|.|..|: :|..|:                          |:|
  Fly   189 -HMLLAKQIGIDHIVVFINKVDAADEEM-VDLVEM--------------------------EIR- 224

  Fly   209 DPSKGSVGFGSGLHGWAFTLKQFSEMYSEKFKIDVVKLMNRLWGENFFNAKTKKWQKQKEADNKR 273
                                :..:||..:..||.|||                          ..
  Fly   225 --------------------ELLTEMGYDGDKIPVVK--------------------------GS 243

  Fly   274 SFCMYILDPIYKVFDAIMNYKKEEIGTLLEKIGVTLKHEDKDKDGKALLKTVMRTWLPAGEALLQ 338
            :.|             .:..|..|||.                  :|:||            |||
  Fly   244 ALC-------------ALEDKSPEIGK------------------EAILK------------LLQ 265

  Fly   339 MIAIHLPSPVVAQKYRMEMLYEGPHDDEAAIAVKSCDPDGPLMMYISKMVPTSDKGRFYAFGRVF 403
            .:...:|:||      .|:                   |.|.::.:..:.....:|.... ||:.
  Fly   266 EVDSFIPTPV------REL-------------------DKPFLLPVENVYSIPGRGTVVT-GRLE 304

  Fly   404 AGKVATGQKCRIMGPNYTPGKKEDLYEKAIQRTILMMGRYVEAIEDVPSGNICGLV--GVDQFLV 466
            .|.|..|.:|..:|           |.|.::.|:..:..:.:.:|:..:|:..|.:  ||.:..:
  Fly   305 RGVVKKGMECEFVG-----------YNKVLKSTVTGVEMFHQILEEAQAGDQLGALVRGVKRDDI 358

  Fly   467 KTGTIT----TFKDAHNMKVMKFSVSP------------------------VVRVAVEPKN---P 500
            |.|.:.    :.|....::...:.:|.                        .|:|.:..|.   |
  Fly   359 KRGMVMCKPGSVKALDQLEAQVYILSKDEGGRTKPFMSFIQLQMFSRTWDCAVQVQIPDKEMVMP 423

  Fly   501 ADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHL 540
            .:..||:..|.|     |||.    |.|:......|.|.|
  Fly   424 GEDTKLILRLIR-----PMVL----EQGQRFTLRDGNLTL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	108/560 (19%)
		EF2	20..236	CDD:206672	50/221 (23%)
		EF2_snRNP_like_II	380..474	CDD:293901	18/99 (18%)
		EF2_snRNP_III	489..560	CDD:293918	16/79 (20%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839
		eEF2_snRNP_like_C	728..807	CDD:239763
mEFTu1	NP_001163144.1	PRK00049	73..463	CDD:234596	108/560 (19%)
		EF_Tu	81..274	CDD:206671	67/332 (20%)
		EFTU_II	282..368	CDD:293898	18/97 (19%)
		mtEFTU_III	371..462	CDD:294005	18/93 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464552
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840