DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF2 and waw

DIOPT Version :9

Sequence 1:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001027089.1	Gene:	waw / 3771960	FlyBaseID:	FBgn0024182	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	648	Identity:	134/648 - (20%)
Similarity:	219/648 - (33%)	Gaps:	288/648 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TVDEIRGLMDKK--------------RNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETR 55
            |.::::|..::.              ..|||.|:|||||||||||.|.|:...|.|| ...|:.:
  Fly    71 TTNQVKGETEEPSQADLLREFAHMPVERIRNFSIIAHVDHGKSTLADRLLELTGAIA-RNGGQHQ 134

  Fly    56 FTDTRKDEQERCITIKSTAISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVT 120
            ..|..:.|:||.||:|:...|          :|..|..|.      :|:||||:|||||||:||:
  Fly   135 VLDNLQVERERGITVKAQTAS----------IFHRHKGQL------YLLNLIDTPGHVDFSNEVS 183

  Fly   121 AALRVTDGALVVVDCVSGVCVQTETVLRQAIAER----IKPILFMNKMDRALLELQLDAEELYQT 181
            .:|...||.:::||...|  ||.:||....:|::    :.|:|  ||:|
  Fly   184 RSLAACDGVVLLVDACHG--VQAQTVANYHLAKQRQLAVVPVL--NKID---------------- 228

  Fly   182 FQRIVENVNVIIATYNDDGGPMGEVRVDPSKGSVGFGSGLHGWAFTLKQFSEMYSEKFKIDVVKL 246
                       |...|.|                                          .|.:.
  Fly   229 -----------IKHANPD------------------------------------------QVCQD 240

  Fly   247 MNRLWGENFFNAKTKKWQKQKEADNKRSFCMYILDPIYKVFDAIMNYKKEEIGT----LLEKIGV 307
            :..|:|                           :||     |.::.. ..::||    :||::..
  Fly   241 LKLLFG---------------------------IDP-----DEVLRV-SAKLGTGVSEVLERVIE 272

  Fly   308 TL--KHEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYR--MEMLY--EG---PH 363
            |:  ....:|.|.:||   :..:|.                    .|||  :.::|  .|   .:
  Fly   273 TVPPPQVQRDSDFRAL---IFDSWF--------------------DKYRGALNLIYVLNGKLEQN 314

  Fly   364 DDEAAIAVKSCDPDGPLMMYISKMVPTSDKGRFYAFGRVFAGKVATGQKCRIMGPNYTPGKKEDL 428
            .|..::|.|                                 ||.:.:...::.|...|
  Fly   315 QDIQSLATK---------------------------------KVYSVKSISVLRPAECP------ 340

  Fly   429 YEKAIQRTILMMGRYVEAIEDVPSGNICGLVGVDQFLVKTGTITTFKDAHNMKVMKFSV------ 487
                              :.||.:|.: ||:                 |.||:..|.|:
  Fly   341 ------------------VPDVSAGQV-GLI-----------------ACNMRNSKESIVGDTIH 369

  Fly   488 ---------------SPVVRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCIIEES---GEHIIAG 534
                           .|:|...|.|.:.:....|...:.::..:|..|...|:.|   |:....|
  Fly   370 LKNQAVAAAGSYRPQQPLVFAGVFPADQSKHVALRSAIDKMVLNDSAVTVKIDSSPALGQGWRLG 434

  Fly   535 -AGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVS-------EESDQMCLSKS---PNKHN 586
             .|.||:|:..:.||::|...|:..: |.|:||..:|       :..|.|.:|.:   |..|:
  Fly   435 FLGLLHMEVFCQRLEQEHGAEPIITA-PSVTYRLVLSNPKMIKQQGRDTMDISNAALFPEPHS 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	134/648 (21%)
		EF2	20..236	CDD:206672	64/219 (29%)
		EF2_snRNP_like_II	380..474	CDD:293901	9/93 (10%)
		EF2_snRNP_III	489..560	CDD:293918	19/74 (26%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	10/37 (27%)
		eEF2_snRNP_like_C	728..807	CDD:239763
waw	NP_001027089.1	PRK05433	94..695	CDD:235462	132/625 (21%)
		LepA	100..277	CDD:206677	75/299 (25%)
		EF4_II	285..370	CDD:293900	25/182 (14%)
		EF4_III	386..461	CDD:293917	19/75 (25%)
		lepA_C	502..581	CDD:239680
		LepA_C	589..695	CDD:283959
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464684
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840