DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF2 and AT3G12915

DIOPT Version :9

Sequence 1:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001154611.1	Gene:	AT3G12915 / 3768815	AraportID:	AT3G12915	Length:	820	Species:	Arabidopsis thaliana

Alignment Length:	827	Identity:	507/827 - (61%)
Similarity:	633/827 - (76%)	Gaps:	11/827 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 MSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTRKDEQERCITIKSTAISMYFEVEEKDL 86
            |||||||||||||||||||:.|||||...||:.|.||||.||.||.||||||.||:|:|:.:..|
plant     1 MSVIAHVDHGKSTLTDSLVAAAGIIAQETAGDVRMTDTRADEAERGITIKSTGISLYYEMTDASL 65

  Fly    87 VFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAI 151
            ...|    ..::...:||||||||||||||||||||||:||||||||||:.||||||||||||::
plant    66 KSFT----GARDGNEYLINLIDSPGHVDFSSEVTAALRITDGALVVVDCIEGVCVQTETVLRQSL 126

  Fly   152 AERIKPILFMNKMDRALLELQLDAEELYQTFQRIVENVNVIIATYNDDGGP-MGEVRVDPSKGSV 215
            .|||:|:|.:|||||..|||::|.||.||.|||::||.|||:||:.|   | :|:|:|.|.||:|
plant   127 GERIRPVLTVNKMDRCFLELKVDGEEAYQNFQRVIENANVIMATHED---PLLGDVQVYPEKGTV 188

  Fly   216 GFGSGLHGWAFTLKQFSEMYSEKFKIDVVKLMNRLWGENFFNAKTKKW-QKQKEADNKRSFCMYI 279
            .|.:|||||||||..|::||:.||.:...|:|.||||||||::.|:|| .|......||.|..:.
plant   189 AFSAGLHGWAFTLTNFAKMYASKFGVSESKMMERLWGENFFDSATRKWTTKTGSPTCKRGFVQFC 253

  Fly   280 LDPIYKVFDAIMNYKKEEIGTLLEKIGVTLKHEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHL 344
            .:||..:.:..||.:|:::..:|||:|:.:|.::|:..||.|:|.||:.||||..|||:|:..||
plant   254 YEPIKIMINTCMNDQKDKLWPMLEKLGIQMKPDEKELMGKPLMKRVMQAWLPASTALLEMMIFHL 318

  Fly   345 PSPVVAQKYRMEMLYEGPHDDEAAIAVKSCDPDGPLMMYISKMVPTSDKGRFYAFGRVFAGKVAT 409
            |||..||:||:|.|||||.||:.|.|:::||||||||:|:|||:|.||||||:||||||:|.|:|
plant   319 PSPYTAQRYRVENLYEGPLDDKYAAAIRNCDPDGPLMLYVSKMIPASDKGRFFAFGRVFSGTVST 383

  Fly   410 GQKCRIMGPNYTPGKKEDLYEKAIQRTILMMGRYVEAIEDVPSGNICGLVGVDQFLVKTGTITTF 474
            |.|.|||||||.||:|:|||.|::|||::.||:..|.:||||.||...:||:|||:.|.||:|..
plant   384 GMKVRIMGPNYVPGEKKDLYVKSVQRTVIWMGKKQETVEDVPCGNTVAMVGLDQFITKNGTLTNE 448

  Fly   475 K--DAHNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGE 537
            |  |||.::.|||||||||||||:.|..:|||||||||||||||||||.|.:|||||||:|||||
plant   449 KEVDAHPLRAMKFSVSPVVRVAVKCKLASDLPKLVEGLKRLAKSDPMVLCTMEESGEHIVAGAGE 513

  Fly   538 LHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQMCLSKSPNKHNRLLMKALPMPDGLPED 602
            ||:|||:|||::......:..||||||.||||.|.|.:..:||||||||||.|:|.||.|||.|.
plant   514 LHIEICVKDLQDFMGGADIIVSDPVVSLRETVFERSCRTVMSKSPNKHNRLYMEARPMEDGLAEA 578

  Fly   603 IDNGDVSAKDEFKARARYLSEKYDYDVTEARKIWCFGPDGTGPNFILDCTKSVQYLNEIKDSVVA 667
            ||.|.:...|:.|.|::.|:|::.:|...|:|||.||||.||||.::|..|.|||||||||||||
plant   579 IDEGRIGPSDDPKIRSKILAEEFGWDKDLAKKIWAFGPDTTGPNMVVDMCKGVQYLNEIKDSVVA 643

  Fly   668 GFQWASKEGILADENLRGVRFNIYDVTLHADAIHRGGGQIIPTTRRCLYAAAITAKPRLMEPVYL 732
            |||||||||.||:||:|||.:.:.||.|||||||||.||:|.|.||.:||:.:||||||:||||:
plant   644 GFQWASKEGPLAEENMRGVCYEVCDVVLHADAIHRGCGQMISTARRAIYASQLTAKPRLLEPVYM 708

  Fly   733 CEIQCPEVAVGGIYGVLNRRRGHVFEENQVVGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQ 797
            .|||.||.|:||||.|||::|||||||.|..|||::.:||||||.|||||:..||:.|.||||||
plant   709 VEIQAPEGALGGIYSVLNQKRGHVFEEMQRPGTPLYNIKAYLPVVESFGFSGQLRAATSGQAFPQ 773

  Fly   798 CVFDHWQVLPGDPSEPSSKPYAIVQDTRKRKGLKEGLPDLSQYLDKL 844
            ||||||.::..||.|..|:...:|.|.|||||||..:..||.|.|||
plant   774 CVFDHWDMMSSDPLETGSQAATLVADIRKRKGLKLQMTPLSDYEDKL 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	505/825 (61%)
		EF2	20..236	CDD:206672	140/214 (65%)
		EF2_snRNP_like_II	380..474	CDD:293901	59/93 (63%)
		EF2_snRNP_III	489..560	CDD:293918	48/70 (69%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	109/171 (64%)
		eEF2_snRNP_like_C	728..807	CDD:239763	54/78 (69%)
AT3G12915	NP_001154611.1	PLN00116	1..820	CDD:177730	505/825 (61%)
		EF2	1..209	CDD:206672	140/214 (65%)
		EF2_II	353..448	CDD:293913	60/94 (64%)
		EF2_snRNP_III	465..536	CDD:293918	48/70 (69%)
		aeEF2_snRNP_like_IV	536..707	CDD:238839	108/170 (64%)
		eEF2_snRNP_like_C	704..782	CDD:239763	54/77 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	384	1.000	Domainoid score	I158
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1068	1.000	Inparanoid score	I34
OMA	1	1.010	-	-		QHG62214
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	1	1.000	-	-		FOG0002412
OrthoInspector	1	1.000	-	-		otm2666
orthoMCL	1	0.900	-	-		OOG6_100212
Panther	1	1.100	-	-	O	PTHR42908
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1605
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840