DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF2 and mEFG1

DIOPT Version :9

Sequence 1:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_609105.1	Gene:	mEFG1 / 34004	FlyBaseID:	FBgn0263133	Length:	745	Species:	Drosophila melanogaster

Alignment Length:	849	Identity:	208/849 - (24%)
Similarity:	336/849 - (39%)	Gaps:	182/849 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IRNMSVIAHVDHGKSTLTDSLVSKAGIIAGA-------KAGETRFTDTRKDEQERCITIKSTAIS 76
            |||:.:.||:|.||:|||:.::...|.||..       ..|.|  .|:.:.|::|.|||:|.|..
  Fly    42 IRNIGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKDNVGAT--MDSMELERQRGITIQSAATY 104

  Fly    77 MYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCV 141
            ..:                    |...||:||:||||||:.||..||||.|||::|:..|.||..
  Fly   105 TLW--------------------KDTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQS 149

  Fly   142 QTETVLRQAIAERIKPILFMNKMDRALLELQLDAEELYQTFQRIVENVNVIIATYNDDGGPMGEV 206
            ||.||.||.....:..:.|:||:||.       ....|:...::...:|...|......|.....
  Fly   150 QTLTVNRQMKRYNVPCLAFINKLDRL-------GSNPYRVLSQMRSKMNHNAAFIQLPIGVESNC 207

  Fly   207 R--VDPSKGSVGFGSGLHGWAFTLKQF-SEMYSEKFK-----IDVVKLMNRLWGENFFNAKTKKW 263
            :  ||..:....:..|.||....|.:. .:|..|..:     |:.:...:...||.|...|....
  Fly   208 KGIVDLVREKAIYFEGEHGMDIRLDEIPQDMRVESLERRQELIEHLSNADETLGELFLEEKPFTE 272

  Fly   264 QKQKEADNKRSFCMYILDPIYKVFDAIMNYKKEEIGTLLEKIGVTLKHEDKDKDGKALLKTVMRT 328
            ...|.|  .|..|      |.:.|..::      :||.|:..||
  Fly   273 DDIKAA--LRRTC------INRTFTPVL------VGTALKNKGV--------------------- 302

  Fly   329 WLPAGEALLQMIAIHLPSPVVAQKYRMEMLYEGPHDDEAAIAVKSCDPDGPLMMYISKMVPTSDK 393
                 :.||..:..:||:|  .:...:..:.:...|.|..:...:.|...|.:....|:    :.
  Fly   303 -----QPLLDAVLDYLPNP--GEVENLGFIEKEGQDPEKVVLNPARDGKDPFVGLAFKL----EA 356

  Fly   394 GRF--YAFGRVFAGKVATGQKCRIMGPNYTPGKKEDLYEKAIQRTILMMGRYVEAIEDVPSGNIC 456
            |||  ..:.|.:.|.:..|....    |....||     ..|.|.:.:....:|.:.:|.:|:|.
  Fly   357 GRFGQLTYLRCYQGVLRKGDNIF----NARTNKK-----VRIARLVRLHSNQMEDVNEVYAGDIF 412

  Fly   457 GLVGVDQFLVKTGTITTFKDAHNMKVMK-FSVSPVVRVAVEPKNPADLPKLVEGLKRLAKSDPMV 520
            .|.|||   ..:|...|....:|:.:.. |...|||.:|::|.|..|.....:.:.|..|.||..
  Fly   413 ALFGVD---CASGDTFTTNPKNNLSMESIFVPEPVVSMAIKPNNTKDRDNFSKAIARFTKEDPTF 474

  Fly   521 QCIIE-ESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQMCLSKSPNK 584
            ....: :..|.:::|.|||||||..:.:|.::.| |:....|.|::|||:..
  Fly   475 HFFFDNDVKETLVSGMGELHLEIYAQRMEREYGC-PVTLGKPKVAFRETLVG------------- 525

  Fly   585 HNRLLMKALPMPDGLPEDIDNGDVSAKDEFKARARYLSEKYDYDVTE-ARKIWCFGPDGTGPNFI 648
                           |.:.|               ||.:|......: ||.|....|.....|.:
  Fly   526 ---------------PCEFD---------------YLHKKQSGGSGQYARIIGVMEPLPPNQNTL 560

  Fly   649 L---DCTKSVQYLNEIKDSVVAGFQWASKEGILADENLRGVRFNIYDVTLHADAIHRGGGQIIPT 710
            |   |.|.......:....|..|::..:::|:|:...|.|:||.:.|          ||..|:.:
  Fly   561 LEFVDETVGTNVPKQFVPGVEKGYREMAEKGMLSGHKLSGIRFRLQD----------GGHHIVDS 615

  Fly   711 TRRCLYAAAITA--------KPRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEENQVVGTPM 767
            :......||..|        ..:::||:.|.|:..||...|.:.|.|::|.|.:.......|  .
  Fly   616 SELAFMLAAHGAIKEVFQNGSWQILEPIMLVEVTAPEEFQGAVMGHLSKRHGIITGTEGTEG--W 678

  Fly   768 FVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPSEPSSKPYAIVQDTRKRKGLKE 832
            |.|.|.:|:|:.||:..:|||:|.|:.  :...::.:..|..|.....    ||:..::.:||.:
  Fly   679 FTVYAEVPLNDMFGYAGELRSSTQGKG--EFTMEYSRYSPCLPDVQDQ----IVRQYQESQGLAQ 737

  Fly   833 GLPD 836
              ||
  Fly   738 --PD 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	208/849 (24%)
		EF2	20..236	CDD:206672	69/225 (31%)
		EF2_snRNP_like_II	380..474	CDD:293901	21/95 (22%)
		EF2_snRNP_III	489..560	CDD:293918	23/71 (32%)
		aeEF2_snRNP_like_IV	560..732	CDD:238839	35/183 (19%)
		eEF2_snRNP_like_C	728..807	CDD:239763	24/78 (31%)
mEFG1	NP_609105.1	EF-G	44..316	CDD:206673	89/340 (26%)
		PRK12740	48..727	CDD:237186	200/827 (24%)
		mtEFG1_II_like	347..427	CDD:293908	21/95 (22%)
		EFG_III	441..516	CDD:293919	23/75 (31%)
		EFG_mtEFG1_IV	519..636	CDD:238715	31/169 (18%)
		mtEFG1_C	641..718	CDD:239764	25/80 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464677
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740